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PDB: 42391 件

5HWL
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Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form
分子名称: GLUTATHIONE, Glutathione S-transferase Mu 2, N,N'-(butane-1,4-diyl)bis{2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide}
著者Zhang, X, Wei, J, Wu, S, Zhang, H.P, Luo, M, Yang, X.L, Liao, F, Wang, D.Q.
登録日2016-01-29
公開日2017-11-08
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form
To Be Published
3FRQ
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Structure of the macrolide biosensor protein, MphR(A), with erythromcyin
分子名称: CHLORIDE ION, ERYTHROMYCIN A, GLYCEROL, ...
著者Zheng, J, Sagar, V, Smolinsky, A, Bourke, C, LaRonde-LeBlanc, N, Cropp, T.A.
登録日2009-01-08
公開日2009-03-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin
J.Mol.Biol., 387, 2009
6TPF
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Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity
分子名称: (1~{S})-2,2-bis(fluoranyl)-~{N}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide, Tyrosine-protein kinase JAK1
著者Hansen, B.B, Jepsen, T.H, Larsen, M, Sindet, R, Vifian, T, Burhardt, M.N, Larsen, J, Seitzberg, J.G, Carnerup, M.A, Jerre, A, Molck, C, Rai, S, Nasipireddy, V.R, Griessner, A, Ritzen, A.
登録日2019-12-13
公開日2020-06-10
最終更新日2020-07-22
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity.
J.Med.Chem., 63, 2020
2Q5I
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Crystal structure of apo S581L Glycyl-tRNA synthetase mutant
分子名称: Glycyl-tRNA synthetase, SULFATE ION
著者Cader, M.Z, Ren, J, James, P.A, Bird, L.E, Talbot, K, Stammers, D.K, Oxford Protein Production Facility (OPPF)
登録日2007-06-01
公開日2007-06-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
Febs Lett., 581, 2007
5HY9
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Glycosylated, disulfide-linked Knob-into-Hole Fc fragment
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Kuglstatter, A, Stihle, M, Benz, J.
登録日2016-02-01
公開日2017-02-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.
Protein Eng. Des. Sel., 30, 2017
3FQZ
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Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6-methylpyrimidine
分子名称: 5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Trimethoprim-sensitive dihydrofolate reductase
著者Anderson, A.C, Frey, K.M, Liu, J, Lombardo, M.N.
登録日2009-01-07
公開日2009-03-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.
J.Mol.Biol., 387, 2009
6TQB
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BU of 6tqb by Molmil
X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE1 SL RNA motif
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ...
著者Binas, O, Tants, J.-N, Peter, S.A, Janowski, R, Davydova, E, Braun, J, Niessing, D, Schwalbe, H, Weigand, J.E, Schlundt, A.
登録日2019-12-16
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
Nucleic Acids Res., 48, 2020
3T8K
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The crystal structure of a functionally unknown protein Lebu_0176 from Leptotrichia buccalis C-1013-b
分子名称: uncharacterized protein
著者Tan, K, Bigelow, L, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2011-08-01
公開日2011-08-31
実験手法X-RAY DIFFRACTION (1.769 Å)
主引用文献The crystal structure of a functionally unknown protein Lebu_0176 from Leptotrichia buccalis C-1013-b
To be Published
4ZPH
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Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine
分子名称: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN
著者Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F.
登録日2015-05-07
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZR6
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Lymnaea Stagnalis Acetylcholine Binding Protein in Complex with 3-[(4E)-4-[(3-methylimidazol-4-yl)methylene]-2,3-dihydropyrrol-5-yl]pyridine
分子名称: 3-{(4E)-4-[(1-methyl-1H-imidazol-5-yl)methylidene]-3,4-dihydro-2H-pyrrol-5-yl}pyridine, Acetylcholine-binding protein
著者Bobango, J, Bryant, D, Denton, T.T, Talley, T.T.
登録日2015-05-11
公開日2016-05-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-guided design and analysis of arylidene anabaseines and myosmines
To be Published
5HP4
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Crystal structure bacteriohage T5 D15 flap endonuclease (D155K) pseudo-enzyme-product complex with DNA and metal ions
分子名称: CALCIUM ION, DNA (5'-D(*GP*AP*TP*CP*TP*AP*TP*AP*TP*GP*CP*CP*AP*TP*CP*GP*G)-3'), Exodeoxyribonuclease, ...
著者Almalki, F.A, Zhang, J, Sedelnikova, S.E, Rafferty, J.B, Sayers, J.R, Artymiuk, P.A.
登録日2016-01-20
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Direct observation of DNA threading in flap endonuclease complexes.
Nat.Struct.Mol.Biol., 23, 2016
4ZEW
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Crystal structure of PfHAD1 in complex with glucose-6-phosphate
分子名称: 6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, PHOSPHATE ION, ...
著者Park, J, Tolia, N.H.
登録日2015-04-20
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
6LHI
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Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with C466 (compound 42) and NADPH
分子名称: 1-[3-[(4-chlorophenyl)-(phenylmethyl)amino]propoxy]-6,6-dimethyl-1,3,5-triazine-2,4-diamine, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ...
著者Vanichtanankul, J, Vitsupakorn, D.
登録日2019-12-09
公開日2020-12-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.
Eur.J.Med.Chem., 195, 2020
6LJR
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human galectin-16 R55N/H57R
分子名称: Galectin-16, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Su, J.
登録日2019-12-17
公開日2020-10-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity.
Biochim Biophys Acta Gen Subj, 1865, 2020
5HQE
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with compound 18T
分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Huang, J, Wu, D, Lu, Q.
登録日2016-01-21
公開日2016-07-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18T at 1.62 A resolution
To Be Published
6TTZ
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Structure of the ClpP:ADEP4-complex from Staphylococcus aureus (open state)
分子名称: ATP-dependent Clp protease proteolytic subunit, N-[(2S)-3-(3,5-difluorophenyl)-1-[[(3S,9S,13S,15R,19S,22S)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetrazatetracyclo[20.4.0.03,7.013,17]hexacosan-9-yl]amino]-1-oxopropan-2-yl]heptanamide
著者Malik, I.T, Pereira, R, Vielberg, M.-T, Mayer, C, Straetener, J, Thomy, D, Famulla, K, Castro, H.C, Sass, P, Groll, M, Broetz-Oesterheldt, H.
登録日2019-12-30
公開日2020-03-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes.
Chembiochem, 21, 2020
3FWX
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The crystal structure of the peptide deformylase from Vibrio cholerae O1 biovar El Tor str. N16961
分子名称: Peptide deformylase, ZINC ION
著者Zhang, R, Zhou, M, Stam, J, Anderson, W, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2009-01-19
公開日2009-03-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of the peptide deformylase from Vibrio cholerae O1 biovar El Tor
To be Published
2PLJ
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Crystal structure of lysine/ornithine decarboxylase complexed with putrescine from Vibrio vulnificus
分子名称: (4-{[(4-AMINOBUTYL)AMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, MAGNESIUM ION, lysine/ornithine decarboxylase
著者Lee, J, Goldsmith, E.J, Phillips, M.A.
登録日2007-04-19
公開日2007-07-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
J.Biol.Chem., 282, 2007
4ZR5
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Soluble rabbit neprilysin in complex with phosphoramidon
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ...
著者Labiuk, S.L, Grochulski, P, Sygusch, J.
登録日2015-05-11
公開日2016-06-08
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8016 Å)
主引用文献Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan.
Acta Crystallogr.,Sect.F, 75, 2019
3T7T
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Crystal structure of complex of SAH and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482
分子名称: Putative methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Kumar, V, Sivaraman, J.
登録日2011-07-31
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus
J.Struct.Biol., 2011
2PM7
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Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version
分子名称: Protein transport protein SEC13, Protein transport protein SEC31
著者Goldberg, J, Fath, S, Mancias, J.D, Bi, X.
登録日2007-04-20
公開日2007-07-03
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure and Organization of Coat Proteins in the COPII Cage.
Cell(Cambridge,Mass.), 129, 2007
3TBM
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BU of 3tbm by Molmil
Crystal structure of a type 4 CDGSH iron-sulfur protein.
分子名称: FE2/S2 (INORGANIC) CLUSTER, L(+)-TARTARIC ACID, NONAETHYLENE GLYCOL, ...
著者Lin, J, Zhang, L, Ye, K.
登録日2011-08-07
公開日2011-10-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains.
Plos One, 6, 2011
4ZGN
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Structure Cdc123 complexed with the C-terminal domain of eIF2gamma
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division cycle protein 123, Eukaryotic translation initiation factor 2 subunit gamma, ...
著者Panvert, M, Dubiez, E, Arnold, L, Perez, J, Seufert, W, Mechulam, Y, Schmitt, E.
登録日2015-04-23
公開日2015-09-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features.
Structure, 23, 2015
6TR2
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Pre-folded structures govern folding pathways of human telomeric G-quadruplexes
分子名称: DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3')
著者Wang, B, Frelih, T, Plavec, J, Sket, P.
登録日2019-12-17
公開日2020-01-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Pre-folded structures govern folding pathways of human telomeric G-quadruplexes.
Nucleic Acids Res., 48, 2020
6TR8
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Corynebacterium diphtheriae methionine sulfoxide reductase B (MsrB) solution structure - reduced form
分子名称: Peptide-methionine (R)-S-oxide reductase, ZINC ION
著者Volkov, A.N, Tossounian, M.A, Buts, L, Messens, J.
登録日2019-12-18
公開日2020-02-05
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Methionine sulfoxide reductase B fromCorynebacterium diphtheriaecatalyzes sulfoxide reduction via an intramolecular disulfide cascade.
J.Biol.Chem., 295, 2020

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