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PDB: 42880 件
8SRN
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De novo designed transmembrane antiparallel homo-dimer G-X6-G 01322-42
分子名称: Gx6G_denovo_design_01322-42
著者Golden, J, Dai, X, Mravic, M.
登録日2023-05-05
公開日2024-09-04
実験手法X-RAY DIFFRACTION (3.275 Å)
主引用文献De Novo Design Reveals Principles of a Common Membrane Protein Structural Building Block: The G-X6-G Motif
To Be Published
5J8B
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BU of 5j8b by Molmil
Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Gagnon, M.G, Lin, J, Steitz, T.A.
登録日2016-04-07
公開日2016-05-25
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Elongation factor 4 remodels the A-site tRNA on the ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
8T4Z
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BU of 8t4z by Molmil
T-cell receptor and lipid complex structure
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, Beta-2-microglobulin, ...
著者Praveena, T, Rossjohn, J.
登録日2023-06-12
公開日2024-08-07
最終更新日2024-09-04
実験手法X-RAY DIFFRACTION (2.691 Å)
主引用文献Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells.
Proc.Natl.Acad.Sci.USA, 121, 2024
5JFU
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BU of 5jfu by Molmil
HIV-1 wild Type protease with GRL-007-14A (a Adamantane P1-Ligand with bis-THF in P2 and benzylamine in P1')
分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-{benzyl[(4-methoxyphenyl)sulfonyl]amino}-3-hydroxy-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]butan-2-yl}carbamate, CHLORIDE ION, Protease
著者Wang, Y.-F, Agniswamy, J, Weber, I.T.
登録日2016-04-19
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.
J.Med.Chem., 59, 2016
8T5H
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BU of 8t5h by Molmil
Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation
分子名称: 16S, 23S, 30S ribosomal protein S10, ...
著者Bhattacharjee, S, Gottesman, M.E, Frank, J.
登録日2023-06-13
公開日2024-08-28
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献How Dedicated Ribosomes Translate a Leaderless mRNA.
J.Mol.Biol., 436, 2024
7QSW
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BU of 7qsw by Molmil
L8S8-complex forming RubisCO derived from ancestral sequence reconstruction of the last common ancestor of SSU-bearing Form I RubisCOs
分子名称: 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit, ...
著者Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A.
登録日2022-01-14
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Science, 378, 2022
7FCC
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BU of 7fcc by Molmil
IL-1RAcPb TIR domain
分子名称: Isoform 4 of Interleukin-1 receptor accessory protein
著者Wang, X, Zhou, J.
登録日2021-07-14
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.144 Å)
主引用文献Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022
7QSV
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BU of 7qsv by Molmil
L8-complex forming RubisCO derived from ancestral sequence reconstruction of the last common ancestor of Form I'' and Form I RubisCOs
分子名称: 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit
著者Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A.
登録日2022-01-14
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Science, 378, 2022
8T5D
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BU of 8t5d by Molmil
Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation
分子名称: 16s RNA, 23S RNA, 30S ribosomal protein S10, ...
著者Bhattacharjee, S, Gottesman, M.E, Frank, J.
登録日2023-06-13
公開日2024-08-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献How Dedicated Ribosomes Translate a Leaderless mRNA.
J.Mol.Biol., 436, 2024
7FCJ
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BU of 7fcj by Molmil
Zebrafish SIGIRR TIR domain mutant - C299S
分子名称: SIGIRR protein
著者Wang, X, Zhou, J.
登録日2021-07-15
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022
8T7D
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BU of 8t7d by Molmil
Crystal structure of wild type IDH1 bound to compound 1
分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide
著者Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M.
登録日2023-06-20
公開日2024-08-28
実験手法X-RAY DIFFRACTION (3.444 Å)
主引用文献Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
7FCH
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BU of 7fch by Molmil
IL-18Rbeta TIR domain
分子名称: Interleukin-18 receptor accessory protein
著者Wang, X, Zhou, J.
登録日2021-07-14
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.883 Å)
主引用文献Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022
5J4H
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BU of 5j4h by Molmil
Structure of humanised RadA-mutant humRadA22F in complex with indole-6-carboxylic acid
分子名称: 1H-indole-6-carboxylic acid, CALCIUM ION, DIMETHYL SULFOXIDE, ...
著者Fischer, G, Marsh, M, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M.
登録日2016-04-01
公開日2016-10-19
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.374 Å)
主引用文献Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
7C6B
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BU of 7c6b by Molmil
Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate
分子名称: 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2
著者Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F.
登録日2020-05-21
公開日2020-11-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 27, 2021
7FD3
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BU of 7fd3 by Molmil
IL-1RAPL2 TIR domain
分子名称: X-linked interleukin-1 receptor accessory protein-like 2
著者Wang, X, Zhou, J.
登録日2021-07-15
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022
7QSY
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BU of 7qsy by Molmil
Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8S8 complex
分子名称: 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit, ...
著者Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A.
登録日2022-01-14
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Science, 378, 2022
1LD5
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BU of 1ld5 by Molmil
STRUCTURE OF BPTI MUTANT A16V
分子名称: PANCREATIC TRYPSIN INHIBITOR
著者Cierpicki, T, Otlewski, J.
登録日2002-04-08
公開日2002-09-11
最終更新日2021-10-27
実験手法SOLUTION NMR
主引用文献NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability.
J.Mol.Biol., 321, 2002
7QSZ
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BU of 7qsz by Molmil
Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8 complex with substitution e170N
分子名称: 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit
著者Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A.
登録日2022-01-14
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Science, 378, 2022
1ZXC
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BU of 1zxc by Molmil
Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor
分子名称: (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ADAM 17, ZINC ION
著者Levin, J.I, Chen, J.M, Laakso, L.M, Du, M, Schmid, J, Xu, W, Cummons, T, Xu, J, Zhang, Y, Jin, G, Cowling, R, Barone, D, Skotnicki, J.S.
登録日2005-06-07
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Bioorg.Med.Chem.Lett., 15, 2005
7QY5
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BU of 7qy5 by Molmil
Crystal structure of the S.pombe Ars2-Red1 complex.
分子名称: NURS complex subunit pir2, RNA elimination defective protein Red1, ZINC ION
著者Foucher, A.E, Kadlec, J.
登録日2022-01-27
公開日2022-11-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
Nat Commun, 13, 2022
2NM2
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BU of 2nm2 by Molmil
Crystal structure of dihydroneopterin aldolase from S. aureus in complex with (1S,2R)-neopterin at 1.50 Angstrom resolution
分子名称: Dihydroneopterin aldolase, L-NEOPTERIN
著者Blaszczyk, J, Ji, X, Yan, H.
登録日2006-10-20
公開日2007-09-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase.
J.Mol.Biol., 368, 2007
7XNE
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BU of 7xne by Molmil
Crystal structure of CBP bromodomain liganded with Y08284
分子名称: CREB-binding protein, GLYCEROL, N-[3-(1-cyclopropylpyrazol-4-yl)-2-fluoranyl-5-[(1S)-1-oxidanylethyl]phenyl]-3-ethanoyl-7-methoxy-indolizine-1-carboxamide
著者Xiang, Q, Wang, C, Wu, T, Zhang, C, Hu, Q, Luo, G, Hu, J, Zhuang, X, Zou, L, Shen, H, Wu, X, Zhang, Y, Kong, X, Xu, Y.
登録日2022-04-28
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
J.Med.Chem., 65, 2022
5J97
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BU of 5j97 by Molmil
Dimerization domain of cytoplasmic activation/proliferation-associated protein-2 (caprin-2)
分子名称: Caprin-2
著者Wu, Y, Zhu, J, Huang, X, Du, Z.
登録日2016-04-08
公開日2017-08-09
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Dimerization domain of cytoplasmic activation/proliferation-associated protein-2 (caprin-2)
To Be Published
7X2E
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BU of 7x2e by Molmil
Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C-terminal tail
分子名称: Cadherin-related family member 2, GLYCEROL, Harmonin
著者Yan, W, Chen, G, Li, J.
登録日2022-02-25
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications.
Faseb J., 36, 2022
7FCL
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BU of 7fcl by Molmil
Zebrafish SIGIRR TIR domain
分子名称: SIGIRR protein
著者Wang, X, Zhou, J.
登録日2021-07-15
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022

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件を2024-10-16に公開中

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