5J4H

Structure of humanised RadA-mutant humRadA22F in complex with indole-6-carboxylic acid

Summary for 5J4H

• Entry DOI: 10.2210/pdb5j4h/pdb
• Descriptor: DNA repair and recombination protein RadA, 1H-indole-6-carboxylic acid, SODIUM ION, ... (6 entities in total)
• Functional Keywords: dna repair, fragment based drug design, humanisation, hydrolase
• Biological source: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
• Total number of polymer chains: 1
• Total formula weight: 25724.24

Authors

Fischer, G.,Marsh, M.,Moschetti, T.,Sharpe, T.,Scott, D.,Morgan, M.,Ng, H.,Skidmore, J.,Venkitaraman, A.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2016-04-01, release date: 2016-10-19, Last modification date: 2023-03-29)

• Primary citation: Moschetti, T.,Sharpe, T.,Fischer, G.,Marsh, M.E.,Ng, H.K.,Morgan, M.,Scott, D.E.,Blundell, T.L.,R Venkitaraman, A.,Skidmore, J.,Abell, C.,Hyvonen, M.; Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.; J.Mol.Biol., 428:4589-4607, 2016; PubMed: 27725183; DOI: 10.1016/j.jmb.2016.10.009

Experimental method

X-RAY DIFFRACTION (1.374 Å)