3K74
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![BU of 3k74 by Molmil](/molmil-images/mine/3k74) | Disruption of protein dynamics by an allosteric effector antibody | 分子名称: | Dihydrofolate reductase, Nanobody | 著者 | Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J. | 登録日 | 2009-10-12 | 公開日 | 2010-10-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J.Mol.Biol., 407, 2011
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7QSV
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![BU of 7qsv by Molmil](/molmil-images/mine/7qsv) | L8-complex forming RubisCO derived from ancestral sequence reconstruction of the last common ancestor of Form I'' and Form I RubisCOs | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit | 著者 | Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2022-01-14 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378, 2022
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4N0V
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![BU of 4n0v by Molmil](/molmil-images/mine/4n0v) | Crystal structure of a glutathione S-transferase domain-containing protein (Marinobacter aquaeolei VT8), Target EFI-507332 | 分子名称: | Glutathione S-transferase, N-terminal domain | 著者 | Kim, J, Toro, R, Bhosle, R, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Washington, E, Glenn, A.S, Chowdhury, S, Evans, B, Zhao, S.C, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Stead, M, Jacobson, M.P, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2013-10-02 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of a glutathione S-transferase domain-containing protein (Marinobacter aquaeolei VT8), Target EFI-507332 TO BE PUBLISHED
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5XRL
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5XK7
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![BU of 5xk7 by Molmil](/molmil-images/mine/5xk7) | Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with DMAPP | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.911 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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8BOF
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![BU of 8bof by Molmil](/molmil-images/mine/8bof) | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 12 | 分子名称: | 4-methyl-~{N}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide, Ephrin type-A receptor 2 | 著者 | Linhard, V, Witt, K, Gande, S, Wollenhaupt, J, Lennartz, F, Weiss, M.S, Schwalbe, H. | 登録日 | 2022-11-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor. Chemistry, 29, 2023
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8BDG
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![BU of 8bdg by Molmil](/molmil-images/mine/8bdg) | Tubulin-taxane-2b complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Lucena-Agell, D, Ma, Y, Estevez-Gallego, J, Li, S, Bargsten, K, Altmann, K.H, Gaillard, N, Kamimura, S, Muehlethaler, T, Gago, F, Oliva, M.A, Steinmetz, M.O, Fang, W.S, Diaz, J.F. | 登録日 | 2022-10-19 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural insight into the stabilization of microtubules by taxanes. Elife, 12, 2023
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6X3W
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![BU of 6x3w by Molmil](/molmil-images/mine/6x3w) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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5XKJ
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![BU of 5xkj by Molmil](/molmil-images/mine/5xkj) | Crystal structure of plant receptor ERL1-TMM in complexe with EPF2 | 分子名称: | LRR receptor-like serine/threonine-protein kinase ERL1, Protein EPIDERMAL PATTERNING FACTOR 2, Protein TOO MANY MOUTHS | 著者 | Chai, J, Lin, G. | 登録日 | 2017-05-07 | 公開日 | 2019-01-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.475 Å) | 主引用文献 | A receptor-like protein acts as a specificity switch for the regulation of stomatal development. Genes Dev., 31, 2017
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2O1M
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![BU of 2o1m by Molmil](/molmil-images/mine/2o1m) | Crystal structure of the probable amino-acid ABC transporter extracellular-binding protein ytmK from Bacillus subtilis. Northeast Structural Genomics Consortium target SR572 | 分子名称: | Probable amino-acid ABC transporter extracellular-binding protein ytmK, SULFATE ION | 著者 | Kuzin, A.P, Su, M, Seetharaman, J, Chen, C.X, Fang, Y, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-11-29 | 公開日 | 2006-12-19 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the probable amino-acid ABC transporter extracellular-binding protein ytmK from Bacillus subtilis. Northeast Structural Genomics Consortium target SR572. To be Published
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6QF9
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![BU of 6qf9 by Molmil](/molmil-images/mine/6qf9) | Structure of an anti-Mcl1 scFv | 分子名称: | scFv | 著者 | Luptak, J. | 登録日 | 2019-01-09 | 公開日 | 2019-11-06 | 最終更新日 | 2019-11-13 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1. Acta Crystallogr D Struct Biol, 75, 2019
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8BDF
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![BU of 8bdf by Molmil](/molmil-images/mine/8bdf) | Tubulin-taxane-2a complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Lucena-Agell, D, Ma, Y, Estevez-Gallego, J, Li, S, Bargsten, K, Altmann, K.H, Gaillard, N, Kamimura, S, Muehlethaler, T, Gago, F, Oliva, M.A, Steinmetz, M.O, Fang, W.S, Diaz, J.F. | 登録日 | 2022-10-19 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural insight into the stabilization of microtubules by taxanes. Elife, 12, 2023
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8PMV
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7QSY
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![BU of 7qsy by Molmil](/molmil-images/mine/7qsy) | Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8S8 complex | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit, ... | 著者 | Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2022-01-14 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378, 2022
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6WY3
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![BU of 6wy3 by Molmil](/molmil-images/mine/6wy3) | Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; P212121 form | 分子名称: | RNA (5'-R(*CP*CP*GP*GP*(LV2)P*GP*CP*CP*GP*G)-3') | 著者 | Sekula, B, Ruszkowski, M, Mao, S, Haruehanroengra, P, Sheng, J. | 登録日 | 2020-05-12 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.647 Å) | 主引用文献 | Base pairing, structural and functional insights into N4-methylcytidine (m4C) and N4,N4-dimethylcytidine (m42C) modified RNA. Nucleic Acids Res., 48, 2020
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8PN4
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6WCJ
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![BU of 6wcj by Molmil](/molmil-images/mine/6wcj) | Asymmetric vertex of the clathrin minicoat cage | 分子名称: | Clathrin heavy chain 1, Clathrin light chain B | 著者 | Paraan, M, Mendez, J, Sharum, S, Kurtin, D, He, H, Stagg, S. | 登録日 | 2020-03-30 | 公開日 | 2020-08-19 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | The structures of natively assembled clathrin-coated vesicles. Sci Adv, 6, 2020
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6Q8W
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![BU of 6q8w by Molmil](/molmil-images/mine/6q8w) | Respiratory complex I from Thermus thermophilus with bound Aureothin. | 分子名称: | Aureothin, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Gutierrez-Fernandez, J, Minhas, G.S, Sazanov, L.A. | 登録日 | 2018-12-16 | 公開日 | 2020-09-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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8PNA
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7Y0C
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![BU of 7y0c by Molmil](/molmil-images/mine/7y0c) | Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-1403 Fab heavy chain, BD55-1403 Fab light chain, ... | 著者 | Zhang, Z, Xiao, J. | 登録日 | 2022-06-04 | 公開日 | 2022-09-28 | 最終更新日 | 2023-04-12 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep, 41, 2022
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8BDE
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![BU of 8bde by Molmil](/molmil-images/mine/8bde) | Tubulin-baccatin III complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Lucena-Agell, D, Ma, Y, Estevez-Gallego, J, Li, S, Bargsten, K, Altmann, K.H, Gaillard, N, Kamimura, S, Muehlethaler, T, Gago, F, Oliva, M.A, Steinmetz, M.O, Fang, W.S, Diaz, J.F. | 登録日 | 2022-10-19 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | Structural insight into the stabilization of microtubules by taxanes. Elife, 12, 2023
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8BQD
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![BU of 8bqd by Molmil](/molmil-images/mine/8bqd) | Yeast 80S ribosome in complex with Map1 (conformation 1) | 分子名称: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | 著者 | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | 登録日 | 2022-11-21 | 公開日 | 2023-03-22 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains. Plos Biol., 21, 2023
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7QSZ
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![BU of 7qsz by Molmil](/molmil-images/mine/7qsz) | Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8 complex with substitution e170N | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit | 著者 | Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2022-01-14 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378, 2022
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8PMF
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8PMN
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