8BDG
Tubulin-taxane-2b complex
Summary for 8BDG
Entry DOI | 10.2210/pdb8bdg/pdb |
Related | 7A7F 7A7I |
Descriptor | Tubulin alpha-1B chain, [(1~{S},2~{S},3~{R},4~{S},7~{R},9~{S},10~{S},12~{R},15~{S})-4-acetyloxy-15-[(2~{R},3~{S})-3-(2-bromanylethanoylamino)-2-oxidanyl-3-phenyl-propanoyl]oxy-10,14,16,16-tetramethyl-1,9,12-tris(oxidanyl)-11-oxidanylidene-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl] benzoate, Tubulin beta-2B chain, ... (11 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265578.32 |
Authors | Prota, A.E.,Lucena-Agell, D.,Ma, Y.,Estevez-Gallego, J.,Li, S.,Bargsten, K.,Altmann, K.H.,Gaillard, N.,Kamimura, S.,Muehlethaler, T.,Gago, F.,Oliva, M.A.,Steinmetz, M.O.,Fang, W.S.,Diaz, J.F. (deposition date: 2022-10-19, release date: 2023-03-22, Last modification date: 2024-02-07) |
Primary citation | Prota, A.E.,Lucena-Agell, D.,Ma, Y.,Estevez-Gallego, J.,Li, S.,Bargsten, K.,Josa-Prado, F.,Altmann, K.H.,Gaillard, N.,Kamimura, S.,Muhlethaler, T.,Gago, F.,Oliva, M.A.,Steinmetz, M.O.,Fang, W.S.,Diaz, J.F. Structural insight into the stabilization of microtubules by taxanes. Elife, 12:-, 2023 Cited by PubMed: 36876916DOI: 10.7554/eLife.84791 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
Download full validation report