4X6H
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![BU of 4x6h by Molmil](/molmil-images/mine/4x6h) | Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. | 分子名称: | 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide, Cathepsin K, ... | 著者 | Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. | 登録日 | 2014-12-08 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
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7VOH
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4WPO
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![BU of 4wpo by Molmil](/molmil-images/mine/4wpo) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Lin, J, Gagnon, M.G, Steitz, T.A. | 登録日 | 2014-10-20 | 公開日 | 2015-01-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation. Cell, 160, 2015
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7CR4
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![BU of 7cr4 by Molmil](/molmil-images/mine/7cr4) | human KCNQ2-CaM in complex with ztz240 | 分子名称: | Calmodulin-3, N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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4K8P
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![BU of 4k8p by Molmil](/molmil-images/mine/4k8p) | Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-ethylbenzyl alcohol | 分子名称: | (2-ETHYLPHENYL)METHANOL, ADENOSINE, DIMETHYL SULFOXIDE, ... | 著者 | Malashkevich, V.N, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Khafizov, K, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-04-18 | 公開日 | 2013-05-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-ethylbenzyl alcohol To be Published
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6O5A
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5ZWX
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6O6H
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![BU of 6o6h by Molmil](/molmil-images/mine/6o6h) | RIAM cc-RA-PH structure in the P21212 space group | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | 著者 | Wu, J. | 登録日 | 2019-03-06 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM. Structure, 2020
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6O6N
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![BU of 6o6n by Molmil](/molmil-images/mine/6o6n) | Structure of the regulator FasR from Mycobacterium tuberculosis in complex with C20-CoA | 分子名称: | Arachinoyl-CoA, CHLORIDE ION, TetR family transcriptional regulator | 著者 | Larrieux, N, Trajtenberg, F, Lara, J, Gramajo, H, Buschiazzo, A. | 登録日 | 2019-03-07 | 公開日 | 2020-03-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. Nat Commun, 11, 2020
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5HWX
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![BU of 5hwx by Molmil](/molmil-images/mine/5hwx) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and zero Ca2+ | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, PENTADECANE, ... | 著者 | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | 登録日 | 2016-01-29 | 公開日 | 2016-05-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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6OY4
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![BU of 6oy4 by Molmil](/molmil-images/mine/6oy4) | Crystal structure of complex between recombinant Der p 2.0103 and Fab fragment of 7A1 | 分子名称: | Der p 2 variant 3, Fab fragment of IgG, HEAVY CHAIN, ... | 著者 | Kapingidza, A.B, Offermann, L.R, Glesner, J, Wunschmann, S, Vailes, L.D, Chapman, M.D.C, Pomes, A, Chruszcz, M. | 登録日 | 2019-05-14 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy. J Immunol., 203, 2019
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5HXC
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![BU of 5hxc by Molmil](/molmil-images/mine/5hxc) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 20 mM Na+ and zero Ca2+ | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CALCIUM ION, ... | 著者 | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | 登録日 | 2016-01-30 | 公開日 | 2016-05-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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4WTP
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![BU of 4wtp by Molmil](/molmil-images/mine/4wtp) | Crystal structure of glycoside hydrolase family 17 beta-1,3-glucanosyltransferase from Rhizomucor miehei | 分子名称: | 1,2-ETHANEDIOL, beta-1,3-glucanosyltransferase | 著者 | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | 登録日 | 2014-10-30 | 公開日 | 2015-08-12 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
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4WTS
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![BU of 4wts by Molmil](/molmil-images/mine/4wts) | Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaritriose | 分子名称: | beta-1,3-glucanosyltransferase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | 著者 | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | 登録日 | 2014-10-30 | 公開日 | 2015-08-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
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4WUJ
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![BU of 4wuj by Molmil](/molmil-images/mine/4wuj) | Structural Biochemistry of a Fungal LOV Domain Photoreceptor Reveals an Evolutionarily Conserved Pathway Integrating Blue-Light and Oxidative Stress | 分子名称: | FLAVIN MONONUCLEOTIDE, Glycoside hydrolase family 15, cellulose signaling associated protein envoy, ... | 著者 | Hopkins, H.C, Lokhandwala, J, Zoltowski, B.D. | 登録日 | 2014-10-31 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Structural Biochemistry of a Fungal LOV Domain Photoreceptor Reveals an Evolutionarily Conserved Pathway Integrating Light and Oxidative Stress. Structure, 23, 2015
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6OOL
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![BU of 6ool by Molmil](/molmil-images/mine/6ool) | Structural elucidation of the Ectodomain of mouse UNC5H2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Netrin receptor UNC5B, ... | 著者 | Stetefeld, J, McDougall, M.D, Loewen, P.C, Moya, A, Meier, M. | 登録日 | 2019-04-23 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural elucidation of the Ectodomain of mouse UNC5H2 To be published
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6OST
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![BU of 6ost by Molmil](/molmil-images/mine/6ost) | RF2 pre-accommodated state bound Release complex 70S at 24ms | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Fu, Z, Indrisiunaite, G, Kaledhonkar, S, Shah, B, Sun, M, Chen, B, Grassucci, R.A, Ehrenberg, M, Frank, J. | 登録日 | 2019-05-02 | 公開日 | 2019-06-19 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Nat Commun, 10, 2019
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6KZL
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7VQX
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![BU of 7vqx by Molmil](/molmil-images/mine/7vqx) | Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W. | 登録日 | 2021-10-21 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13, 2022
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6OT9
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![BU of 6ot9 by Molmil](/molmil-images/mine/6ot9) | Bimetallic dodecameric cage design 1 (BMC1) from cytochrome cb562 | 分子名称: | ACETOHYDROXAMIC ACID, FE (III) ION, HEME C, ... | 著者 | Golub, E, Esselborn, J, Bailey, J.B, Tezcan, F.A. | 登録日 | 2019-05-02 | 公開日 | 2020-01-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Constructing protein polyhedra via orthogonal chemical interactions. Nature, 578, 2020
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7VRB
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![BU of 7vrb by Molmil](/molmil-images/mine/7vrb) | Structure of the Human BRG1/SS18 complex | 分子名称: | SMARCA4 protein,Protein SSXT | 著者 | Cheng, Y, Chen, F, Zhou, H, Long, J. | 登録日 | 2021-10-22 | 公開日 | 2022-05-25 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.389 Å) | 主引用文献 | Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas. Nat Commun, 13, 2022
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5HWA
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![BU of 5hwa by Molmil](/molmil-images/mine/5hwa) | Crystal Structure of MH-K1 chitosanase in substrate-bound form | 分子名称: | 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, ACETIC ACID, CACODYLATE ION, ... | 著者 | Suzuki, M, Saito, A, Ando, A, Miki, K, Saito, J. | 登録日 | 2016-01-29 | 公開日 | 2017-02-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure of the GH-46 subclass III chitosanase from Bacillus circulans MH-K1 in complex with chitotetraose Biomed.Biochim.Acta, 1868, 2024
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6KVS
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![BU of 6kvs by Molmil](/molmil-images/mine/6kvs) | Staphylococcus aureus FabH with covalent inhibitor Oxa1 | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 3, 4-chloranyl-N-[[cyclopropylmethyl(methanoyl)amino]methyl]benzamide | 著者 | Yuan, Y, Wang, J. | 登録日 | 2019-09-05 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase To Be Published
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4X8H
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![BU of 4x8h by Molmil](/molmil-images/mine/4x8h) | Crystal structure of E. coli Adenylate kinase P177A mutant | 分子名称: | Adenylate kinase | 著者 | Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. | 登録日 | 2014-12-10 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for catalytically restrictive dynamics of a high-energy enzyme state. Nat Commun, 6, 2015
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5HXE
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![BU of 5hxe by Molmil](/molmil-images/mine/5hxe) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 100 mM Na+ and zero Ca2+ | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, PENTADECANE, ... | 著者 | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | 登録日 | 2016-01-30 | 公開日 | 2016-05-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | 主引用文献 | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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