8F6Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f6z by Molmil](/molmil-images/mine/8f6z) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-17 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
|
|
4OK7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ok7 by Molmil](/molmil-images/mine/4ok7) | Structure of bacteriophage SPN1S endolysin from Salmonella typhimurium | 分子名称: | Endolysin, GLYCEROL, SULFATE ION | 著者 | Park, Y, Lim, J, Kong, M, Ryu, S, Rhee, S. | 登録日 | 2014-01-22 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of bacteriophage SPN1S endolysin reveals an unusual two-module fold for the peptidoglycan lytic and binding activity. Mol.Microbiol., 92, 2014
|
|
8F2S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f2s by Molmil](/molmil-images/mine/8f2s) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-08 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
|
|
2RD1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rd1 by Molmil](/molmil-images/mine/2rd1) | X-Ray structure of the protein Q7CQI7. Northeast Structural Genomics Consortium target StR87A | 分子名称: | Putative outer membrane lipoprotein | 著者 | Kuzin, A.P, Su, M, Seetharaman, J, Vorobiev, S.M, Wang, D, Fang, Y, Owens, L, Mao, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-09-20 | 公開日 | 2007-10-09 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | X-Ray structure of the protein Q7CQI7. To be Published
|
|
4ZIP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4zip by Molmil](/molmil-images/mine/4zip) | HIV-1 wild Type protease with GRL-0648A (a isophthalamide-derived P2-Ligand) | 分子名称: | CHLORIDE ION, GLYCEROL, N-[(2,5-dimethyl-1,3-oxazol-4-yl)methyl]-N'-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-N,5-dimethylbenzene-1,3-dicarboxamide, ... | 著者 | Wang, Y.-F, Agniswamy, J, Weber, I.T. | 登録日 | 2015-04-28 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | 主引用文献 | Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands. Bioorg.Med.Chem.Lett., 25, 2015
|
|
3HPK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hpk by Molmil](/molmil-images/mine/3hpk) | |
3EC8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ec8 by Molmil](/molmil-images/mine/3ec8) | The crystal structure of the RA domain of FLJ10324 (RADIL) | 分子名称: | CHLORIDE ION, GLYCEROL, LEAD (II) ION, ... | 著者 | Wisniewska, M, Lehtio, L, Andersson, J, Arrowsmith, C.H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Olesen, K, Persson, C, Sagemark, J, Schueler, H, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Wikstrom, M, Berglund, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-08-29 | 公開日 | 2008-09-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The crystal structure of the RA domain of FLJ10324 (RADIL) to be published
|
|
4PVT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pvt by Molmil](/molmil-images/mine/4pvt) | Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302F | 分子名称: | (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ... | 著者 | Aik, W.S, Brem, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2014-03-18 | 公開日 | 2014-11-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition. Nat.Chem., 6, 2014
|
|
4PW6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pw6 by Molmil](/molmil-images/mine/4pw6) | structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II | 分子名称: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | 著者 | Zhou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | 登録日 | 2014-03-18 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.789 Å) | 主引用文献 | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
|
|
3W20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3w20 by Molmil](/molmil-images/mine/3w20) | Crystal Structure of a Novel N-Substituted L-Amino Acid Dioxygenase from Burkholderia ambifaria AMMD | 分子名称: | Putative uncharacterized protein, ZINC ION | 著者 | Qin, H.M, Miyakawa, T, Jia, M.Z, Nakamura, A, Ohtsuka, J, Xue, Y.L, Kawashima, T, Kasahara, T, Hibi, M, Ogawa, J, Tanokura, M. | 登録日 | 2012-11-26 | 公開日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Crystal Structure of a Novel N-Substituted L-Amino Acid Dioxygenase from Burkholderia ambifaria AMMD Plos One, 8, 2013
|
|
6IM0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6im0 by Molmil](/molmil-images/mine/6im0) | Crystal structure of a highly thermostable carbonic anhydrase from Persephonella marina EX-H1 | 分子名称: | BICARBONATE ION, CALCIUM ION, Carbonic anhydrase (Carbonate dehydratase), ... | 著者 | Jin, M.S, Kim, S, Sung, J, Yeon, J, Choi, S.H. | 登録日 | 2018-10-21 | 公開日 | 2019-07-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of a Highly Thermostable alpha-Carbonic Anhydrase from Persephonella marina EX-H1. Mol.Cells, 42, 2019
|
|
4PW5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pw5 by Molmil](/molmil-images/mine/4pw5) | structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I | 分子名称: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | 著者 | ZHou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | 登録日 | 2014-03-18 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.204 Å) | 主引用文献 | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
|
|
4CSU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4csu by Molmil](/molmil-images/mine/4csu) | Cryo-EM structures of the 50S ribosome subunit bound with ObgE | 分子名称: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L11, ... | 著者 | Feng, B, Mandava, C.S, Guo, Q, Wang, J, Cao, W, Li, N, Zhang, Y, Zhang, Y, Wang, Z, Wu, J, Sanyal, S, Lei, J, Gao, N. | 登録日 | 2014-03-10 | 公開日 | 2014-06-04 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase. Plos Biol., 12, 2014
|
|
5L8P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l8p by Molmil](/molmil-images/mine/5l8p) | Thermolysin in complex with JC114 (PEG400 cryo protectant) | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, N~2~-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-[(2S)-2,3,3-trimethylbutyl]-L-leucinamide, ... | 著者 | Krimmer, S.G, Cramer, J, Heine, A, Klebe, G. | 登録日 | 2016-06-08 | 公開日 | 2016-12-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands. J. Med. Chem., 59, 2016
|
|
2MKL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mkl by Molmil](/molmil-images/mine/2mkl) | |
4ZNN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4znn by Molmil](/molmil-images/mine/4znn) | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | 分子名称: | Alpha-synuclein | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | 登録日 | 2015-05-05 | 公開日 | 2015-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
|
|
2RKF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rkf by Molmil](/molmil-images/mine/2rkf) | HIV-1 PR resistant mutant + LPV | 分子名称: | GLYCEROL, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, PROTEASE RETROPEPSIN, ... | 著者 | Rezacova, P, Brynda, J, Kozisek, M, Saskova, K.G, Konvalinka, J. | 登録日 | 2007-10-16 | 公開日 | 2008-08-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region J.Virol., 82, 2008
|
|
4Q2C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q2c by Molmil](/molmil-images/mine/4q2c) | Crystal structure of CRISPR-associated protein | 分子名称: | CRISPR-associated helicase Cas3, NICKEL (II) ION | 著者 | Gong, B, Shin, M, Sun, J, van der Oost, J, Kim, J.-S. | 登録日 | 2014-04-07 | 公開日 | 2014-11-19 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4ZP2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4zp2 by Molmil](/molmil-images/mine/4zp2) | Crystal structure of E. coli multidrug transporter MdfA in complex with n-dodecyl-N,N-dimethylamine-N-oxide | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, Multidrug transporter MdfA | 著者 | Zhang, X.C, Heng, J, Zhao, Y, Wang, X. | 登録日 | 2015-05-07 | 公開日 | 2015-08-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Substrate-bound structure of the E. coli multidrug resistance transporter MdfA Cell Res., 25, 2015
|
|
4Q60
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q60 by Molmil](/molmil-images/mine/4q60) | Crystal structure of a 4-hydroxyproline epimerase from Burkholderia Multivorans atcc 17616, target EFI-506586, open form, with bound pyrrole-2-carboxylate | 分子名称: | GLYCEROL, PROLINE RACEMASE, PYRROLE-2-CARBOXYLATE | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Al Obaidi, N, Sojitra, S, Stead, M, Washington, E, Glenn, A.S, Chowdhury, S, Evans, B, Hammonds, J, Hillerich, B, Love, J, Seidel, R.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-04-18 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | CRYSTAL STRUCTURE OF PROLINE RACEMASE Bmul_4447 FROM Burkholderia multivorans, TARGET EFI-506586 To be Published
|
|
8EU3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8eu3 by Molmil](/molmil-images/mine/8eu3) | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | 著者 | Hu, Z, Zheng, X, Yang, J. | 登録日 | 2022-10-18 | 公開日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Commun, 14, 2023
|
|
5L15
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l15 by Molmil](/molmil-images/mine/5l15) | The crystal structure of neuraminidase in complex with oseltamivir from A/Shanghai/2/2013 (H7N9) influenza virus | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Yang, H, Stevens, J. | 登録日 | 2016-07-28 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Drug Susceptibility Evaluation of an Influenza A(H7N9) Virus by Analyzing Recombinant Neuraminidase Proteins. J. Infect. Dis., 216, 2017
|
|
8F0K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f0k by Molmil](/molmil-images/mine/8f0k) | Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 | 分子名称: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Cao, J, Sexton, P.M, Wootten, D.L. | 登録日 | 2022-11-03 | 公開日 | 2023-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
|
|
8F2B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f2b by Molmil](/molmil-images/mine/8f2b) | Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45 | 分子名称: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J. | 登録日 | 2022-11-07 | 公開日 | 2023-08-02 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
|
|
4Q94
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q94 by Molmil](/molmil-images/mine/4q94) | human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide | 分子名称: | Regulation of nuclear pre-mRNA domain-containing protein 1B, SULFATE ION, UNKNOWN ATOM OR ION, ... | 著者 | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | 登録日 | 2014-04-29 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat.Struct.Mol.Biol., 21, 2014
|
|