3FN8
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6C3O
| Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Lee, K.P.K, Chen, J, MacKinnon, R. | 登録日 | 2018-01-10 | 公開日 | 2018-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of human KATP in complex with ATP and ADP Elife, 6, 2017
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6E0E
| Crystal structure of Glucokinase in complex with compound 6 | 分子名称: | 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile, Glucokinase, alpha-D-glucopyranose | 著者 | Hinklin, R.J, Baer, B.R, Boyd, S.A, Chicarelli, M.D, Condroski, K.R, DeWolf, W.E, Fischer, J, Frank, M, Hingorani, G.P, Lee, P.A, Neitzel, N.A, Pratt, S.A, Singh, A, Sullivan, F.X, Turner, T, Voegtli, W.C, Wallace, E.M, Williams, L, Aicher, T.D. | 登録日 | 2018-07-06 | 公開日 | 2019-07-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg.Med.Chem., 28, 2020
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6E12
| Crystal Structure of the Alr8543 protein in complex with Oleic Acid and magnesium ion from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR141 | 分子名称: | Alr8543 protein, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Forouhar, F, Neely, H, Seetharaman, J, Xiao, R, Ciccosanti, C, Patel, D, Belote, R.L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2018-07-09 | 公開日 | 2018-07-25 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of the Alr8543 protein in complex with Oleic Acid and magnesium ion from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR141 To Be Published
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6C5V
| An anti-gH/gL antibody that neutralizes dual-tropic infection defines a site of vulnerability on Epstein-Barr virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab AMMO1 heavy chain, Antibody Fab AMMO1 light chain, ... | 著者 | Snijder, J, Ortego, M.S, Weidle, C, Stuart, A.B, Gray, M.A, McElrath, M.J, Pancera, M, Veesler, D, McGuire, A.T, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2018-01-16 | 公開日 | 2018-05-02 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus. Immunity, 48, 2018
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7ZU0
| HOPS tethering complex from yeast | 分子名称: | E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ... | 著者 | Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C. | 登録日 | 2022-05-11 | 公開日 | 2022-09-28 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of the endosomal CORVET tethering complex. Nat Commun, 15, 2024
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6C9W
| Crystal Structure of a ligand bound LacY/Nanobody Complex | 分子名称: | 4-nitrophenyl alpha-D-galactopyranoside, Lactose permease, Nanobody9047, ... | 著者 | Kumar, H, Finer-Moore, J.S, Jiang, X, Smirnova, I, Kasho, V, Pardon, E, Steyaert, J, Kaback, H.R, Stroud, R.M. | 登録日 | 2018-01-29 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1FG0
| LARGE RIBOSOMAL SUBUNIT COMPLEXED WITH A 13 BP MINIHELIX-PUROMYCIN COMPOUND | 分子名称: | 23S RIBOSOMAL RNA, 5'-R(CCGGCGGGCUGGUUCAAACCGGCCCGCCGGACC)-3'-5'-R(P-PUROMYCIN)-3' | 著者 | Nissen, P, Hansen, J, Ban, N, Moore, P.B, Steitz, T.A. | 登録日 | 2000-07-26 | 公開日 | 2000-08-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structural basis of ribosome activity in peptide bond synthesis. Science, 289, 2000
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6CHX
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3FZE
| Structure of the 'minimal scaffold' (ms) domain of Ste5 that cocatalyzes Fus3 phosphorylation by Ste7 | 分子名称: | Protein STE5 | 著者 | Good, M.C, Tang, G, Singleton, J, Remenyi, A, Lim, W.A. | 登録日 | 2009-01-25 | 公開日 | 2009-03-31 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell(Cambridge,Mass.), 136, 2009
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3FQ9
| Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | 分子名称: | Insulin, ZINC ION | 著者 | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | 登録日 | 2009-01-07 | 公開日 | 2009-08-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J.Biol.Chem., 284, 2009
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3FVS
| Human Kynurenine Aminotransferase I in complex with Glycerol | 分子名称: | GLYCEROL, Kynurenine--oxoglutarate transaminase 1, SODIUM ION | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | 登録日 | 2009-01-16 | 公開日 | 2009-05-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J.Med.Chem., 52, 2009
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6CL4
| LipC12 - Lipase from metagenomics | 分子名称: | Lipase C12 | 著者 | Iulek, J, Martini, V.P, Krieger, N, Glogauer, A, Souza, E.M. | 登録日 | 2018-03-01 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structure solution and analyses of the first true lipase obtained from metagenomics indicate potential for increased thermostability. N Biotechnol, 53, 2019
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6CLF
| 1.15 A MicroED structure of GSNQNNF at 1.9 e- / A^2 | 分子名称: | ACETATE ION, GSNQNNF, ZINC ION | 著者 | Hattne, J, Shi, D, Glynn, C, Zee, C.-T, Gallagher-Jones, M, Martynowycz, M.W, Rodriguez, J.A, Gonen, T. | 登録日 | 2018-03-02 | 公開日 | 2018-05-16 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.15 Å) | 主引用文献 | Analysis of Global and Site-Specific Radiation Damage in Cryo-EM. Structure, 26, 2018
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3FQV
| Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6-methylpyrimidine | 分子名称: | 5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Trimethoprim-sensitive dihydrofolate reductase | 著者 | Anderson, A.C, Frey, K.M, Liu, J, Lombardo, M.N. | 登録日 | 2009-01-07 | 公開日 | 2009-03-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol., 387, 2009
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6CLO
| 1.15 A MicroED structure of GSNQNNF at 2.1 e- / A^2 | 分子名称: | ACETATE ION, GSNQNNF, ZINC ION | 著者 | Hattne, J, Shi, D, Glynn, C, Zee, C.-T, Gallagher-Jones, M, Martynowycz, M.W, Rodriguez, J.A, Gonen, T. | 登録日 | 2018-03-02 | 公開日 | 2018-05-16 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.15 Å) | 主引用文献 | Analysis of Global and Site-Specific Radiation Damage in Cryo-EM. Structure, 26, 2018
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3FR2
| N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors | 分子名称: | 9-benzyl-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid, Fatty acid-binding protein, adipocyte | 著者 | Barf, T, Hammer, K, Lehmann, F, Haile, S, Axen, E, Medina, C, Rondahl, L, Uppenberg, J, Svensson, S, Lundb ck, T. | 登録日 | 2009-01-08 | 公開日 | 2009-03-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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2HEB
| CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY | 分子名称: | LYSOZYME, SODIUM ION | 著者 | Takano, K, Funahashi, J, Yamagata, Y, Fujii, S, Yutani, K. | 登録日 | 1997-09-16 | 公開日 | 1998-01-28 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Contribution of water molecules in the interior of a protein to the conformational stability. J.Mol.Biol., 274, 1997
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3FRT
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3FR5
| N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors | 分子名称: | 5-(3-carbamoylbenzyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-4-carboxylic acid, Fatty acid-binding protein, adipocyte | 著者 | Barf, T, Hammer, K, Lehmann, F, Haile, S, Axen, E, Medina, C, Uppenberg, J, Svensson, S, Rondahl, L, Lundb ck, T. | 登録日 | 2009-01-08 | 公開日 | 2009-03-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3FRN
| CRYSTAL STRUCTURE OF flagellar protein FlgA FROM Thermotoga maritima MSB8 | 分子名称: | Flagellar protein FlgA, GLYCEROL | 著者 | Patskovsky, Y, Bonanno, J.B, Romero, R, Gilmore, M, Hu, S, Bain, K, Koss, J, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2009-01-08 | 公開日 | 2009-02-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | CRYSTAL STRUCTURE OF flagellar protein FlgA FROM Thermotoga maritima To be Published
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2HEA
| CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY | 分子名称: | LYSOZYME, SODIUM ION | 著者 | Takano, K, Funahashi, J, Yamagata, Y, Fujii, S, Yutani, K. | 登録日 | 1997-09-16 | 公開日 | 1998-01-14 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Contribution of water molecules in the interior of a protein to the conformational stability. J.Mol.Biol., 274, 1997
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2HEF
| CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY | 分子名称: | LYSOZYME, SODIUM ION | 著者 | Takano, K, Funahashi, J, Yamagata, Y, Fujii, S, Yutani, K. | 登録日 | 1997-09-16 | 公開日 | 1998-01-14 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Contribution of water molecules in the interior of a protein to the conformational stability. J.Mol.Biol., 274, 1997
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6CPL
| Crystal structure of DR11 presenting the gag293 epitope | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Farenc, C, Gras, S, Rossjohn, J. | 登録日 | 2018-03-13 | 公開日 | 2018-06-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | CD4+T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 3, 2018
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3DFQ
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