1E9F
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![BU of 1e9f by Molmil](/molmil-images/mine/1e9f) | Mutant human thymidylate kinase complexed with TMP and ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-11 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9C
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![BU of 1e9c by Molmil](/molmil-images/mine/1e9c) | Mutant human thymidylate kinase complexed with TMP and APPNP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9A
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![BU of 1e9a by Molmil](/molmil-images/mine/1e9a) | Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A | 分子名称: | MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, THYMIDYLATE KINASE | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9B
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![BU of 1e9b by Molmil](/molmil-images/mine/1e9b) | Human thymidylate kinase complexed with AZTMP and APPNP | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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2VSC
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![BU of 2vsc by Molmil](/molmil-images/mine/2vsc) | Structure of the immunoglobulin-superfamily ectodomain of human CD47 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEUKOCYTE SURFACE ANTIGEN CD47, MAGNESIUM ION | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | 登録日 | 2008-04-22 | 公開日 | 2008-08-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47. Mol.Cell, 31, 2008
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2VU9
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![BU of 2vu9 by Molmil](/molmil-images/mine/2vu9) | CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A BINDING DOMAIN IN COMPLEX WITH GT1B | 分子名称: | BOTULINUM NEUROTOXIN A HEAVY CHAIN, MAGNESIUM ION, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | 著者 | Stenmark, P, Dupuy, J, Stevens, R.C. | 登録日 | 2008-05-22 | 公開日 | 2008-08-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of Botulinum Neurotoxin Type a in Complex with the Cell Surface Co-Receptor Gt1B- Insight Into the Toxin-Neuron Interaction. Plos Pathog., 4, 2008
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5LJP
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2W1F
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![BU of 2w1f by Molmil](/molmil-images/mine/2w1f) | Structure determination of Aurora Kinase in complex with inhibitor | 分子名称: | N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE, SERINE/THREONINE-PROTEIN KINASE 6 | 著者 | Howard, S, Berdini, V, Boulstridge, J.A, Carr, M.G, Cross, D.M, Curry, J, Devine, L.A, Early, T.R, Fazal, L, Gill, A.L, Heathcote, M, Maman, S, Matthews, J.E, McMenamin, R.L, Navarro, E.F, O'Brien, M.A, O'Reilly, M, Rees, D.C, Reule, M, Tisi, D, Williams, G, Vinkovic, M, Wyatt, P.G. | 登録日 | 2008-10-17 | 公開日 | 2009-01-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. J.Med.Chem., 52, 2009
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7FIR
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![BU of 7fir by Molmil](/molmil-images/mine/7fir) | The crystal structure of beta-1,2-mannobiose phosphorylase in complex with 1,4-mannobiose | 分子名称: | Beta-1,2-mannobiose phosphorylase, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | 著者 | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | 登録日 | 2021-08-01 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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6JF1
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![BU of 6jf1 by Molmil](/molmil-images/mine/6jf1) | Crystal structure of the substrate binding protein of a methionine transporter from Streptococcus pneumoniae | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Jha, B, Vyas, R, Bhushan, J, Sehgal, D, Biswal, B.K. | 登録日 | 2019-02-07 | 公開日 | 2019-07-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a methionine ABC transporter from Streptococcus pneumoniae. Acta Crystallogr.,Sect.F, 75, 2019
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7FIQ
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![BU of 7fiq by Molmil](/molmil-images/mine/7fiq) | The crystal structure of mannose-bound beta-1,2-mannobiose phosphorylase from Thermoanaerobacter sp. | 分子名称: | Beta-1,2-mannobiose phosphorylase, GLYCEROL, PENTAETHYLENE GLYCOL, ... | 著者 | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | 登録日 | 2021-08-01 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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7FIP
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![BU of 7fip by Molmil](/molmil-images/mine/7fip) | The native structure of beta-1,2-mannobiose phosphorylase from Thermoanaerobacter sp. | 分子名称: | Beta-1,2-mannobiose phosphorylase, ZINC ION | 著者 | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | 登録日 | 2021-08-01 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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7FIS
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![BU of 7fis by Molmil](/molmil-images/mine/7fis) | The crystal structure of beta-1,2-mannobiose phosphorylase in complex with mannose 1-phosphate (M1P) | 分子名称: | 1-O-phosphono-alpha-D-mannopyranose, Beta-1,2-mannobiose phosphorylase, GLYCEROL, ... | 著者 | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | 登録日 | 2021-08-01 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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2VS7
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![BU of 2vs7 by Molmil](/molmil-images/mine/2vs7) | The crystal structure of I-DmoI in complex with DNA and Ca | 分子名称: | 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP *CP*TP*TP*AP*CP*CP*CP*GP*GP*CP*AP*AP*GP*GP*C)-3', 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP *GP*TP*AP*AP*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*G)-3', ACETATE ION, ... | 著者 | Marcaida, M.J, Prieto, J, Redondo, P, Nadra, A.D, Alibes, A, Serrano, L, Grizot, S, Duchateau, P, Paques, F, Blanco, F.J, Montoya, G. | 登録日 | 2008-04-21 | 公開日 | 2008-11-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure of I-Dmoi in Complex with its Target DNA Provides New Insights Into Meganuclease Engineering. Proc.Natl.Acad.Sci.USA, 105, 2008
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2W0N
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![BU of 2w0n by Molmil](/molmil-images/mine/2w0n) | Plasticity of PAS domain and potential role for signal transduction in the histidine-kinase DcuS | 分子名称: | SENSOR PROTEIN DCUS | 著者 | Etzkorn, M, Kneuper, H, Duennwald, P, Vijayan, V, Kraemer, J, Griesinger, C, Becker, S, Unden, G, Baldus, M. | 登録日 | 2008-08-19 | 公開日 | 2008-09-30 | 最終更新日 | 2024-05-15 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Plasticity of the Pas Domain and a Potential Role for Signal Transduction in the Histidine Kinase Dcus. Nat.Struct.Mol.Biol., 15, 2008
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6JHP
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6JHJ
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![BU of 6jhj by Molmil](/molmil-images/mine/6jhj) | Structure of Marine bacterial laminarinase mutant-E135A | 分子名称: | CALCIUM ION, LamCAT | 著者 | Yang, J, Xu, Y, Miyakawa, T, Tanokura, M, Long, L. | 登録日 | 2019-02-18 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Molecular Basis for Substrate Recognition and Catalysis by a Marine Bacterial Laminarinase. Appl.Environ.Microbiol., 86, 2020
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5LH4
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![BU of 5lh4 by Molmil](/molmil-images/mine/5lh4) | Trypsin inhibitors for the treatment of pancreatitis - cpd 1 | 分子名称: | (2~{S},4~{S})-1-[4-(aminomethyl)phenyl]carbonyl-4-(4-cyclopropyl-1,2,3-triazol-1-yl)-~{N}-(2,2-diphenylethyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ... | 著者 | Schiering, N, D'Arcy, A, Skaanderup, P, Simic, O, Brandl, T, Woelcke, J. | 登録日 | 2016-07-08 | 公開日 | 2018-01-17 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Trypsin inhibitors for the treatment of pancreatitis. Bioorg. Med. Chem. Lett., 26, 2016
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6JHR
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![BU of 6jhr by Molmil](/molmil-images/mine/6jhr) | The cryo-EM structure of HAV bound to a neutralizing antibody-F6 | 分子名称: | FAB Heavy Chain, FAB Light Chain, VP1, ... | 著者 | Cao, L, Liu, P, Yang, P, Gao, Q, Li, H, Sun, Y, Zhu, L, Lin, J, Su, D, Rao, Z, Wang, X. | 登録日 | 2019-02-18 | 公開日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors. Plos Biol., 17, 2019
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1F45
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![BU of 1f45 by Molmil](/molmil-images/mine/1f45) | HUMAN INTERLEUKIN-12 | 分子名称: | INTERLEUKIN-12 ALPHA CHAIN, INTERLEUKIN-12 BETA CHAIN, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yoon, C, Johnston, S.C, Tang, J, Tobin, J.F, Somers, W.S. | 登録日 | 2000-06-07 | 公開日 | 2001-06-20 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. EMBO J., 19, 2000
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6JI3
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![BU of 6ji3 by Molmil](/molmil-images/mine/6ji3) | BRD4-BD1 bound with ligand 103 | 分子名称: | (3~{R})-4-cyclopropyl-1,3-dimethyl-6-(1~{H}-pyrrol-2-yl)-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4 | 著者 | Cao, D.Y, Li, Y.L, Du, Z.Y, Li, J, Xiong, B. | 登録日 | 2019-02-20 | 公開日 | 2020-02-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | brd4-bd1 bound with ligand 103 To Be Published
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2W1G
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![BU of 2w1g by Molmil](/molmil-images/mine/2w1g) | Structure determination of Aurora Kinase in complex with inhibitor | 分子名称: | 2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-6-(MORPHOLIN-4-IUM-4-YLMETHYL)-1H-3,1-BENZIMIDAZOL-3-IUM, SERINE/THREONINE-PROTEIN KINASE 6 | 著者 | Howard, S, Berdini, V, Boulstridge, J.A, Carr, M.G, Cross, D.M, Curry, J, Devine, L.A, Early, T.R, Fazal, L, Gill, A.L, Heathcote, M, Maman, S, Matthews, J.E, McMenamin, R.L, Navarro, E.F, O'Brien, M.A, O'Reilly, M, Rees, D.C, Reule, M, Tisi, D, Williams, G, Vinkovic, M, Wyatt, P.G. | 登録日 | 2008-10-17 | 公開日 | 2009-01-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. J.Med.Chem., 52, 2009
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2MT5
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![BU of 2mt5 by Molmil](/molmil-images/mine/2mt5) | Isolated Ring domain | 分子名称: | Anaphase-promoting complex subunit 11, ZINC ION | 著者 | Brown, N.G, Watson, E.R, Weissman, F, Royappa, G, Schulman, B, Jarvis, M, Vanderlinden, R, Frye, J.J, Qiao, R, Petzold, G, Peters, J, Stark, H. | 登録日 | 2014-08-13 | 公開日 | 2014-10-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly. Mol.Cell, 56, 2014
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1I8N
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![BU of 1i8n by Molmil](/molmil-images/mine/1i8n) | CRYSTAL STRUCTURE OF LEECH ANTI-PLATELET PROTEIN | 分子名称: | ANTI-PLATELET PROTEIN, PROPIONAMIDE | 著者 | Huizinga, E.G, Schouten, A, Connolly, T.M, Kroon, J, Sixma, J.J, Gros, P. | 登録日 | 2001-03-15 | 公開日 | 2001-08-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of leech anti-platelet protein, an inhibitor of haemostasis. Acta Crystallogr.,Sect.D, 57, 2001
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5LNG
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![BU of 5lng by Molmil](/molmil-images/mine/5lng) | Lectin domain of E. coli F9 pilus adhesin FmlH | 分子名称: | Putative Fml fimbrial adhesin FmlD, SULFATE ION | 著者 | Ruer, S, Conover, M.S, Kalas, V, Taganna, J, De Greve, H, Pinkner, J.S, Dodson, K.W, Hultgren, S.J, Remaut, H. | 登録日 | 2016-08-04 | 公開日 | 2016-10-05 | 最終更新日 | 2018-01-31 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection. Cell Host Microbe, 20, 2016
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