5GIE
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![BU of 5gie by Molmil](/molmil-images/mine/5gie) | Crystal structure of VDR in complex with DLAM-4P (P21 form) | 分子名称: | (3R,5S)-5-[(2R)-2-[(1R,3aS,4E,7aR)-7a-methyl-4-[(2Z)-2-[(3S,5R)-2-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methyl-3-oxidanyl-1-(4-phenylbutyl)pyrrolidin-2-one, SRC1, Vitamin D3 receptor | 著者 | Asano, L, Shimizu, T. | 登録日 | 2016-06-23 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.387 Å) | 主引用文献 | Regulation of the vitamin D receptor by vitamin D lactam derivatives. Febs Lett., 590, 2016
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1V9Z
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![BU of 1v9z by Molmil](/molmil-images/mine/1v9z) | Crystal Structure of the heme PAS sensor domain of Ec DOS (Ferrous Form) | 分子名称: | Heme pas sensor protein, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kurokawa, H, Lee, D.S, Watanabe, M, Sagami, I, Mikami, B, Raman, C.S, Shimizu, T. | 登録日 | 2004-02-04 | 公開日 | 2004-05-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor. J.Biol.Chem., 279, 2004
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5DST
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7BQI
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![BU of 7bqi by Molmil](/molmil-images/mine/7bqi) | |
3A57
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![BU of 3a57 by Molmil](/molmil-images/mine/3a57) | Crystal structure of Thermostable Direct Hemolysin | 分子名称: | Thermostable direct hemolysin 2 | 著者 | Hashimoto, H, Yanagihara, I, Nakahira, K, Hamada, D, Ikegami, T, Mayanagi, K, Kaieda, S, Fukui, T, Ohnishi, K, Kajiyama, S, Yamane, T, Ikeguchi, M, Honda, T, Shimizu, T, Sato, M. | 登録日 | 2009-08-03 | 公開日 | 2010-03-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin J.Biol.Chem., 285, 2010
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5AWC
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![BU of 5awc by Molmil](/molmil-images/mine/5awc) | Crystal structure of human TLR8 in complex with MB-564 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2016-07-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published
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5AZ5
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![BU of 5az5 by Molmil](/molmil-images/mine/5az5) | Crystal structure of human TLR8 in complex with MB-343 | 分子名称: | 1-pentyl-4-phenyl-imidazol-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-09-27 | 公開日 | 2016-10-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of human TLR8 in complex with MB-343 To Be Published
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1NPM
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![BU of 1npm by Molmil](/molmil-images/mine/1npm) | NEUROPSIN, A SERINE PROTEASE EXPRESSED IN THE LIMBIC SYSTEM OF MOUSE BRAIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEUROPSIN | 著者 | Kishi, T, Kato, M, Shimizu, T, Kato, K, Matsumoto, K, Yoshida, S, Shiosaka, S, Hakoshima, T. | 登録日 | 1998-01-07 | 公開日 | 1999-03-23 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis. J.Biol.Chem., 274, 1999
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3A8R
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![BU of 3a8r by Molmil](/molmil-images/mine/3a8r) | The structure of the N-terminal regulatory domain of a plant NADPH oxidase | 分子名称: | CALCIUM ION, Putative uncharacterized protein | 著者 | Oda, T, Hashimoto, H, Kuwabara, N, Akashi, S, Hayashi, K, Kojima, C, Wong, H.L, Kawasaki, T, Shimamoto, K, Sato, M, Shimizu, T. | 登録日 | 2009-10-07 | 公開日 | 2009-10-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications J.Biol.Chem., 285, 2010
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5AWB
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![BU of 5awb by Molmil](/molmil-images/mine/5awb) | Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine) | 分子名称: | 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2015-09-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58, 2015
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5AWD
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![BU of 5awd by Molmil](/molmil-images/mine/5awd) | Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ) | 分子名称: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2015-09-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58, 2015
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3ABD
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![BU of 3abd by Molmil](/molmil-images/mine/3abd) | Structure of human REV7 in complex with a human REV3 fragment in a monoclinic crystal | 分子名称: | DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B | 著者 | Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M. | 登録日 | 2009-12-07 | 公開日 | 2010-02-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase {zeta} and REV1 J.Biol.Chem., 285, 2010
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4ZLC
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3ABE
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![BU of 3abe by Molmil](/molmil-images/mine/3abe) | Structure of human REV7 in complex with a human REV3 fragment in a tetragonal crystal | 分子名称: | DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B | 著者 | Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M. | 登録日 | 2009-12-07 | 公開日 | 2010-02-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase {zeta} and REV1 J.Biol.Chem., 285, 2010
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4ZLD
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![BU of 4zld by Molmil](/molmil-images/mine/4zld) | Crystal structure of human Roquin-2 ROQ domain in complex with Roquin CDE RNA | 分子名称: | GLYCEROL, RNA (5'-R(*UP*AP*AP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*UP*UP*G)-3'), Roquin-2 | 著者 | Sakurai, S, Ohto, U, Shimizu, T. | 登録日 | 2015-05-01 | 公開日 | 2015-08-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of human Roquin-2 and its complex with constitutive-decay element RNA Acta Crystallogr.,Sect.F, 71, 2015
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5AWA
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![BU of 5awa by Molmil](/molmil-images/mine/5awa) | Crystal structure of human TLR8 in complex with MB-568 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2016-07-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published
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3AUP
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![BU of 3aup by Molmil](/molmil-images/mine/3aup) | Crystal structure of Basic 7S globulin from soybean | 分子名称: | Basic 7S globulin | 著者 | Yoshizawa, T, Shimizu, T, Taichi, M, Nishiuchi, Y, Yamabe, M, Shichijo, N, Unzai, S, Hirano, H, Sato, M, Hashimoto, H. | 登録日 | 2011-02-14 | 公開日 | 2011-04-27 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Crystal structure of basic 7S globulin, a xyloglucan-specific endo-beta-1,4-glucanase inhibitor protein-like protein from soybean lacking inhibitory activity against endo-beta-glucanase Febs J., 278, 2011
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1CXZ
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![BU of 1cxz by Molmil](/molmil-images/mine/1cxz) | CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1 | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, PROTEIN (HIS-TAGGED TRANSFORMING PROTEIN RHOA(0-181)), ... | 著者 | Maesaki, R, Ihara, K, Shimizu, T, Kuroda, S, Kaibuchi, K, Hakoshima, T. | 登録日 | 1999-08-31 | 公開日 | 1999-10-08 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol.Cell, 4, 1999
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3B1U
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![BU of 3b1u by Molmil](/molmil-images/mine/3b1u) | Crystal structure of human peptidylarginine deiminase 4 in complex with o-F-amidine | 分子名称: | 2-{[(2S)-1-amino-5-{[(1Z)-2-fluoroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, CALCIUM ION, Protein-arginine deiminase type-4, ... | 著者 | Causey, C.P, Jones, J.E, Slack, J.L, Kamei, D, Jones Jr, L.E, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, A.A, Luo, Y, Hashimoto, H, Shimizu, T, Sato, M, Hofseth, L.J, Thompson, P.R. | 登録日 | 2011-07-13 | 公開日 | 2011-10-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors J.Med.Chem., 54, 2011
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3B1T
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![BU of 3b1t by Molmil](/molmil-images/mine/3b1t) | Crystal structure of human peptidylarginine deiminase 4 in complex with o-Cl-amidine | 分子名称: | 2-{[(2S)-1-amino-5-{[(1Z)-2-chloroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, CALCIUM ION, Protein-arginine deiminase type-4, ... | 著者 | Causey, C.P, Jones, J.E, Slack, J.L, Kamei, D, Jones Jr, L.E, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, A.A, Luo, Y, Hashimoto, H, Shimizu, T, Sato, M, Hofseth, L.J, Thompson, P.R. | 登録日 | 2011-07-13 | 公開日 | 2011-10-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors J.Med.Chem., 54, 2011
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1GD2
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![BU of 1gd2 by Molmil](/molmil-images/mine/1gd2) | CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA | 分子名称: | DNA (5'-D(*AP*GP*GP*TP*TP*AP*CP*GP*TP*AP*AP*CP*C)-3'), TRANSCRIPTION FACTOR PAP1 | 著者 | Fujii, Y, Shimizu, T, Toda, T, Yanagida, M, Hakoshima, T. | 登録日 | 2000-08-25 | 公開日 | 2000-10-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the diversity of DNA recognition by bZIP transcription factors. Nat.Struct.Biol., 7, 2000
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4R08
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![BU of 4r08 by Molmil](/molmil-images/mine/4r08) | Crystal structure of human TLR8 in complex with ssRNA40 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-07-30 | 公開日 | 2015-01-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
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4R0A
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![BU of 4r0a by Molmil](/molmil-images/mine/4r0a) | Crystal structure of human TLR8 in complex with uridine mononucleoside | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-07-30 | 公開日 | 2015-01-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
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3ALR
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![BU of 3alr by Molmil](/molmil-images/mine/3alr) | Crystal structure of Nanos | 分子名称: | Nanos protein, ZINC ION | 著者 | Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M. | 登録日 | 2010-08-06 | 公開日 | 2011-02-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of zinc-finger domain of Nanos and its functional implications Embo Rep., 11, 2010
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1BDJ
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![BU of 1bdj by Molmil](/molmil-images/mine/1bdj) | COMPLEX STRUCTURE OF HPT DOMAIN AND CHEY | 分子名称: | AEROBIC RESPIRATION CONTROL SENSOR PROTEIN ARCB, CHEY, SULFATE ION | 著者 | Kato, M, Mizuno, T, Shimizu, T, Hakoshima, T. | 登録日 | 1998-05-10 | 公開日 | 1999-05-11 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor protein ArcB complexed with the chemotaxis response regulator CheY. Acta Crystallogr.,Sect.D, 55, 1999
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