3EMY
| Crystal structure of Trichoderma reesei aspartic proteinase complexed with pepstatin A | Descriptor: | Pepstatin, Trichoderma reesei Aspartic protease | Authors: | Nascimento, A.S, Krauchenco, S, Golubev, A.M, Gustchina, A, Wlodawer, A, Polikarpov, I. | Deposit date: | 2008-09-25 | Release date: | 2008-10-07 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Statistical coupling analysis of aspartic proteinases based on crystal
structures of the Trichoderma reesei enzyme and its complex with pepstatin A. J.Mol.Biol., 382, 2008
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6B3D
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3QV6
| Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with acid blue 80. | Descriptor: | 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Morgan, H.P, Auld, D.S, McNae, I.W, Nowicki, M.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | Deposit date: | 2011-02-25 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J.Biol.Chem., 286, 2011
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3EP9
| Human AdoMetDC with no putrescine bound | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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3EQ2
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2O96
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3UN9
| Crystal structure of an immune receptor | Descriptor: | NLR family member X1, PLATINUM (II) ION | Authors: | Hong, M, Yoon, S.I, Wilson, I.A. | Deposit date: | 2011-11-15 | Release date: | 2012-03-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure and Functional Characterization of the RNA-Binding Element of the NLRX1 Innate Immune Modulator. Immunity, 36, 2012
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3EOE
| Crystal Structure of Pyruvate Kinase from toxoplasma gondii, 55.m00007 | Descriptor: | GLYCEROL, Pyruvate kinase | Authors: | Wernimont, A.K, Lew, J, Kozieradzki, I, Wasney, G, Hassani, A, Vedadi, M, Cossar, D, Schapiro, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Pizarro, J, Structural Genomics Consortium (SGC) | Deposit date: | 2008-09-26 | Release date: | 2008-10-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | The crystal structure of Toxoplasma gondii pyruvate kinase 1. Plos One, 5, 2010
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3EP8
| Human AdoMetDC E178Q mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound | Descriptor: | PYRUVIC ACID, S-ADENOSYLMETHIONINE METHYL ESTER, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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2OGS
| Crystal Structure of the GEOBACILLUS STEAROTHERMOPHILUS Carboxylesterase EST55 at pH 6.2 | Descriptor: | IODIDE ION, Thermostable carboxylesterase Est50 | Authors: | Liu, P, Ewis, H.E, Tai, P.C, Lu, C.D, Weber, I.T. | Deposit date: | 2007-01-08 | Release date: | 2007-02-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11. J.Mol.Biol., 367, 2007
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1U33
| In situ extension as an approach for identifying novel alpha-amylase inhibitors | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4'-O-METHYL-MALTOSYL-ALPHA (1,4)-(Z, 3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-PIPERIDIN-2-ONE, ... | Authors: | Numao, S, Li, C, Damager, I, Wrodnigg, T.M, Begum, A, Overall, C.M, Brayer, G.D, Withers, S.G. | Deposit date: | 2004-07-20 | Release date: | 2004-09-07 | Last modified: | 2020-11-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors. J.Biol.Chem., 279, 2004
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1U2K
| Crystal structure of the C-terminal domain from the catalase-peroxidase KatG of Escherichia coli (I41) | Descriptor: | Peroxidase/catalase HPI | Authors: | Carpena, X, Melik-Adamyan, W, Loewen, P.C, Fita, I. | Deposit date: | 2004-07-19 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli. Acta Crystallogr.,Sect.D, 60, 2004
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6LX6
| X-ray structure of human PPARalpha ligand binding domain-palmitic acid co-crystals obtained by delipidation and cross-seeding | Descriptor: | GLYCEROL, PALMITIC ACID, Peroxisome proliferator-activated receptor alpha | Authors: | Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. | Deposit date: | 2020-02-10 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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6LXB
| X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by soaking | Descriptor: | (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Peroxisome proliferator-activated receptor alpha | Authors: | Kamata, S, Honda, A, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. | Deposit date: | 2020-02-10 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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3EP5
| Human AdoMetDC E178Q mutant with no putrescine bound | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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3EQ7
| Prolyl oligopeptidase complexed with R-Pro-(decarboxy-Pro)-Type inhibitors | Descriptor: | 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione, Prolyl endopeptidase | Authors: | Kanai, K, Aranyi, P, Bocskei, Z, Ferenczy, G, Harmat, V, Simon, K, Naray-Szabo, G, Hermecz, I. | Deposit date: | 2008-09-30 | Release date: | 2009-08-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules J.Med.Chem., 51, 2008
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2IH1
| Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ... | Authors: | Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R. | Deposit date: | 2006-09-25 | Release date: | 2006-11-21 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation. Science, 314, 2006
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4UKD
| UMP/CMP KINASE FROM SLIME MOLD COMPLEXED WITH ADP, UDP, BERYLLIUM FLUORIDE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM DIFLUORIDE, MAGNESIUM ION, ... | Authors: | Schlichting, I, Reinstein, J. | Deposit date: | 1997-05-20 | Release date: | 1998-05-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative. Biochemistry, 36, 1997
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1RR9
| Catalytic domain of E.coli Lon protease | Descriptor: | ATP-dependent protease La, SULFATE ION | Authors: | Botos, I, Melnikov, E.E, Cherry, S, Tropea, J.E, Khalatova, A.G, Dauter, Z, Maurizi, M.R, Rotanova, T.V, Wlodawer, A, Gustchina, A. | Deposit date: | 2003-12-08 | Release date: | 2003-12-23 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site J.Biol.Chem., 279, 2004
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3ELB
| Human CTP: Phosphoethanolamine Cytidylyltransferase in complex with CMP | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, Ethanolamine-phosphate cytidylyltransferase, GLYCEROL | Authors: | Karlberg, T, Welin, M, Andersson, J, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Wikstrom, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-09-22 | Release date: | 2008-10-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human CTP:Phosphoethanolamine Cytidylyltransferase To be Published
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1R15
| Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P | Descriptor: | ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, NICOTINAMIDE | Authors: | Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q. | Deposit date: | 2003-09-23 | Release date: | 2004-03-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure, 12, 2004
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3EP7
| Human AdoMetDC E256Q mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound | Descriptor: | PYRUVIC ACID, S-ADENOSYLMETHIONINE METHYL ESTER, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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4U5Y
| Crystal Structure of the complex between the GNAT domain of S. lividans PAT and the acetyl-CoA synthetase C-terminal domain of S. enterica | Descriptor: | Acetyl-coenzyme A synthetase, Acyl-CoA synthetase, SULFATE ION | Authors: | Taylor, K.C, Tucker, A.C, Rank, K.C, Escalante-Semerena, J.C, Rayment, I. | Deposit date: | 2014-07-25 | Release date: | 2014-11-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.926 Å) | Cite: | Insights into the specificity of lysine acetyltransferases. J.Biol.Chem., 289, 2014
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3EP6
| Human AdoMetDC D174N mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound | Descriptor: | PYRUVIC ACID, S-ADENOSYLMETHIONINE METHYL ESTER, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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1Q8S
| Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man | Descriptor: | CALCIUM ION, MANGANESE (II) ION, alpha-D-mannopyranose-(1-6)-methyl alpha-D-mannopyranoside, ... | Authors: | Loris, R, Van Walle, I, De Greve, H, Beeckmans, S, DeBoeck, F, Wyns, L, Bouckaert, J. | Deposit date: | 2003-08-22 | Release date: | 2004-02-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural Basis of Oligomannose Recognition by the Pterocarpus angolensis Seed Lectin J.Mol.Biol., 335, 2004
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