Human AdoMetDC D174N mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound

Summary for 3EP6

Related1JEN 1I72 1I7B 1I7C 1I7M 1I79 3EP3 3EP4 3EP5 3EP7 3EP8 3EP9 3EPA 3EPB
DescriptorS-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ... (5 entities in total)
Functional Keywordsadometdc with mutation in putrescine binding site, decarboxylase, lyase, pyruvate, s-adenosyl-l-methionine, spermidine biosynthesis, zymogen
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight38084.35
Bale, S.,Lopez, M.M.,Makhatadze, G.I.,Fang, Q.,Pegg, A.E.,Ealick, S.E. (deposition date: 2008-09-29, release date: 2008-12-23, Last modification date: 2017-10-25)
Primary citation
Bale, S.,Lopez, M.M.,Makhatadze, G.I.,Fang, Q.,Pegg, A.E.,Ealick, S.E.
Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47:13404-13417, 2008
PubMed: 19053272 (PDB entries with the same primary citation)
DOI: 10.1021/bi801732m
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23310 0.7% 1.9% 4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21