1A5E
| SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES | 分子名称: | TUMOR SUPPRESSOR P16INK4A | 著者 | Byeon, I.-J.L, Li, J, Ericson, K, Selby, T.L, Tevelev, A, Kim, H.-J, O'Maille, P, Tsai, M.-D. | 登録日 | 1998-02-13 | 公開日 | 1999-08-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4. Mol.Cell, 1, 1998
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7P9B
| Providencia stuartii Arginine decarboxylase (Adc), decamer structure | 分子名称: | Biodegradative arginine decarboxylase | 著者 | Jessop, M, Desfosses, A, Bacia-Verloop, M, Gutsche, I. | 登録日 | 2021-07-26 | 公開日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Structural and biochemical characterisation of the Providencia stuartii arginine decarboxylase shows distinct polymerisation and regulation. Commun Biol, 5, 2022
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7OP6
| Bacteroides thetaiotaomicron mannosidase GH2 with beta-manno-configured cyclophellitol aziridine | 分子名称: | (1~{R},2~{R},3~{S},4~{R},5~{R},6~{R})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol, 1,2-ETHANEDIOL, BROMIDE ION, ... | 著者 | McGregor, N.G.S, Beenakker, T.J.M, Kuo, C, Wong, C, Offen, W.A, Armstrong, Z, Codee, J.D.C, Aerts, J.M.F.G, Florea, B.I, Overkleeft, H.S, Davies, G.J. | 登録日 | 2021-05-29 | 公開日 | 2022-05-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Synthesis of broad-specificity activity-based probes for exo -beta-mannosidases. Org.Biomol.Chem., 20, 2022
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2D31
| Crystal structure of disulfide-linked HLA-G dimer | 分子名称: | 9-mer peptide from Histone H2A, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | 著者 | Shiroishi, M, Kuroki, K, Ose, T, Rasubala, L, Shiratori, I, Arase, H, Tsumoto, K, Kumagai, I, Kohda, D, Maenaka, K. | 登録日 | 2005-09-23 | 公開日 | 2006-03-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Efficient Leukocyte Ig-like Receptor Signaling and Crystal Structure of Disulfide-linked HLA-G Dimer J.Biol.Chem., 281, 2006
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5NZT
| The structure of the COPI coat linkage I | 分子名称: | ADP-ribosylation factor 1, Coatomer subunit alpha, Coatomer subunit beta, ... | 著者 | Dodonova, S.O, Aderhold, P, Kopp, J, Ganeva, I, Roehling, S, Hagen, W.J.H, Sinning, I, Wieland, F, Briggs, J.A.G. | 登録日 | 2017-05-15 | 公開日 | 2017-06-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | 9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. Elife, 6, 2017
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7OLT
| Dioxygenase AsqJ in complex with 2 and Tris | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-Methoxydehydrocyclopeptin, BROMIDE ION, ... | 著者 | Auman, D, Mader, S.L, Ecker, F, Dorst, K, Braeuer, A, Widmalm, G, Groll, M, Kaila, V.R.I. | 登録日 | 2021-05-20 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Peroxy Intermediate Drives Carbon Bond Activation in the Dioxygenase AsqJ. J.Am.Chem.Soc., 144, 2022
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8T3V
| Cryo-EM structure of the DHA bound FFA1-Gq complex | 分子名称: | CHOLESTEROL, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | 著者 | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | 登録日 | 2023-06-07 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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1AWX
| SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | BRUTON'S TYROSINE KINASE | 著者 | Hansson, H, Mattsson, P.T, Allard, P, Haapaniemi, P, Vihinen, M, Smith, C.I.E, Hard, T. | 登録日 | 1997-10-06 | 公開日 | 1998-04-08 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the SH3 domain from Bruton's tyrosine kinase. Biochemistry, 37, 1998
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6NW8
| SOLUTION STRUCTURE OF CN29, A TOXIN FROM CENTRUROIDES NOXIUS SCORPION VENOM | 分子名称: | Cn29 | 著者 | Delepierre, M, Gurrola, G.B, Possani, L.D, Guijarro, J.I. | 登録日 | 2019-02-06 | 公開日 | 2019-07-03 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function. Toxicon, 167, 2019
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1B0X
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7QZM
| ATAD2 in complex with FragLite28 | 分子名称: | 1,2-ETHANEDIOL, 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-31 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QYK
| ATAD2 in complex with FragLite18 | 分子名称: | (4-bromanylpyridin-2-yl)methanol, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-28 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7OSO
| The crystal structure of Erwinia tasmaniensis levansucrase in complex with (S)-1,2,4-butanentriol | 分子名称: | (2~{S})-butane-1,2,4-triol, Levansucrase (Beta-D-fructofuranosyl transferase), ZINC ION | 著者 | Polsinelli, I, Salomone-Stagni, M, Benini, S. | 登録日 | 2021-06-09 | 公開日 | 2022-06-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Erwinia tasmaniensis levansucrase shows enantiomer selection for (S)-1,2,4-butanetriol. Acta Crystallogr.,Sect.F, 78, 2022
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1B28
| ARC REPRESSOR MYL MUTANT FROM SALMONELLA BACTERIOPHAGE P22 | 分子名称: | PROTEIN (REGULATORY PROTEIN ARC) | 著者 | Rietveld, A.W.M, Nooren, I.M.A, Sauer, R.T, Kaptein, R, Boelens, R. | 登録日 | 1998-12-05 | 公開日 | 1999-11-03 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure and dynamics of an Arc repressor mutant reveal premelting conformational changes related to DNA binding. Biochemistry, 38, 1999
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1AUM
| HIV CAPSID C-TERMINAL DOMAIN (CAC146) | 分子名称: | HIV CAPSID | 著者 | Hill, C.P, Gamble, T.R, Yoo, S, Vajdos, F.F, Von Schwedler, U.K, Worthylake, D.K, Wang, H, Mccutcheon, J.P, Sundquist, W.I. | 登録日 | 1997-08-29 | 公開日 | 1998-01-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science, 278, 1997
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7OLA
| Structure of Primase-Helicase in SaPI5 | 分子名称: | DNA primase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Qiao, C.C, Mir-Sanchis, I. | 登録日 | 2021-05-19 | 公開日 | 2022-07-13 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility. Nucleic Acids Res., 50, 2022
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7OM0
| Structure of Primase-Helicase in SaPI5 | 分子名称: | DNA primase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Qiao, C.C, Mir-Sanchis, I. | 登録日 | 2021-05-21 | 公開日 | 2022-07-13 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility. Nucleic Acids Res., 50, 2022
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7R6W
| SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Snell, G, Czudnochowski, N, Hernandez, P, Nix, J.C, Croll, T.I, Corti, D, Cameroni, E, Pinto, D, Beltramello, M. | 登録日 | 2021-06-23 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature, 597, 2021
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8T1F
| Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1B
| Cryo-EM structure of full-length human TRPV4 in apo state | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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6O3C
| Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide, ... | 著者 | Deshpande, I.S, Liang, J, Hedeen, D, Roberts, K.J, Zhang, Y, Ha, B, Latorraca, N.R, Faust, B, Dror, R.O, Beachy, P.A, Myers, B.R, Manglik, A. | 登録日 | 2019-02-26 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571, 2019
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7PCJ
| X-ray structure of CypA-C52AK125C/CsA/aromatic foldamer complex | 分子名称: | 8-azanyl-4-(2-methylpropoxy)quinoline-2-carboxylic acid, 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid, 8-azanyl-4-oxidanyl-quinoline-2-carboxylic acid, ... | 著者 | Vallade, M, Langlois d'Estaintot, B, Fischer, L, Buratto, J, Savko, M, Huc, I. | 登録日 | 2021-08-03 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | X-ray structure of a cystein mutant of Cyclophilin A tethered to an aromatic oligoamide foldamer complexed with Cyclosporin A To Be Published
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8T1E
| Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8VCY
| Human TCR A2.13 in complex with DQ8-InsC8-15NPY | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hybrid insulin peptide (HIP; InsC8-15-NPY68-74), ... | 著者 | Tran, T.M, Lim, J.J, Loh, T.Y, Mannering, I.S, Rossjohn, J, Reid, H.H. | 登録日 | 2023-12-14 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A structural basis of T cell cross-reactivity to a native and spliced self-antigens presented by HLA-DQ8 To Be Published
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8VD2
| Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hybrid insulin peptide (HIP; InsC8-15-IAPP23-29 ), MHC class II HLA-DQ-alpha chain, ... | 著者 | Tran, T.M, Lim, J.J, Loh, T.Y, Mannering, I.S, Rossjohn, J, Reid, H.H. | 登録日 | 2023-12-14 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A structural basis of T cell cross-reactivity to a native and spliced self-antigens presented by HLA-DQ8 To Be Published
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