8VD2

Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP1

Summary for 8VD2

Entry DOI	10.2210/pdb8vd2/pdb
Related	8VCX 8VCY 8VD0 8VDD 8VDU
Descriptor	MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, Hybrid insulin peptide (HIP; InsC8-15-IAPP23-29 ), ... (7 entities in total)
Functional Keywords	immune t cell receptor-pmhc ii complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	95526.47
Authors	Tran, T.M.,Lim, J.J.,Loh, T.Y.,Mannering, I.S.,Rossjohn, J.,Reid, H.H. (deposition date: 2023-12-14, release date: 2024-08-07, Last modification date: 2024-09-04)
Primary citation	Tran, M.T.,Lim, J.J.,Loh, T.J.,Mannering, S.I.,Rossjohn, J.,Reid, H.H. A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8. J.Biol.Chem., 300:107612-107612, 2024 Cited by PubMed: 39074636 DOI: 10.1016/j.jbc.2024.107612 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation