8VD2
Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class II HLA-DQ-alpha chain | polymer | 185 | 21150.6 | 1 | UniProt (Q30069) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | DQA1*03:01 (DQ8-alpha chain |
| 2 | B (B) | MHC class II HLA-DQ-beta-1 | polymer | 192 | 22605.4 | 1 | UniProt (O19707) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | DQB1*03:02 (DQ8-beta chain) |
| 3 | C (C) | Hybrid insulin peptide (HIP; InsC8-15-IAPP23-29 ) | polymer | 15 | 1474.6 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | T-CELL-RECEPTOR, TCR ET650-4 alpha | polymer | 206 | 22921.6 | 1 | Homo sapiens (human) | ||
| 5 | E (E) | T-CELL-RECEPTOR, TCR ET650-4 beta | polymer | 240 | 27153.1 | 1 | Homo sapiens (human) | ||
| 6 | F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: -1 - 182 (UniProt: Q30069)
| PDB | External Database | Details |
|---|---|---|
| Cys 72 | Ile 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 95305.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 95526.5 |
