8VDU
Crystal structure of hybrid insulin peptide (InsC8-15-IAPP74-80) bound to HLA-DQ8
Summary for 8VDU
Entry DOI | 10.2210/pdb8vdu/pdb |
Related | 8VCX 8VCY 8VD0 8VD2 8VDD |
Descriptor | MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, Hybrid insulin peptide (HIP; InsC8-15-IAPP74-80), ... (7 entities in total) |
Functional Keywords | pmhc ii complex, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 182224.53 |
Authors | Tran, T.M.,Lim, J.J.,Loh, T.Y.,Mannering, I.S.,Rossjohn, J.,Reid, H.H. (deposition date: 2023-12-17, release date: 2024-08-07, Last modification date: 2024-09-04) |
Primary citation | Tran, M.T.,Lim, J.J.,Loh, T.J.,Mannering, S.I.,Rossjohn, J.,Reid, H.H. A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8. J.Biol.Chem., 300:107612-107612, 2024 Cited by PubMed: 39074636DOI: 10.1016/j.jbc.2024.107612 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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