8VDU
Crystal structure of hybrid insulin peptide (InsC8-15-IAPP74-80) bound to HLA-DQ8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | MHC class II HLA-DQ-alpha chain | polymer | 185 | 21124.5 | 4 | UniProt (Q30069) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | DQA1*03:01 (DQ8-alpha chain) |
| 2 | B, E, H, K (B, E, H, K) | MHC class II HLA-DQ-beta-1 | polymer | 192 | 22605.4 | 4 | UniProt (O19707) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | DQB1*03:02 (DQ8-beta chain) |
| 3 | C, F, I, L (C, F, I, L) | Hybrid insulin peptide (HIP; InsC8-15-IAPP74-80) | polymer | 15 | 1460.6 | 4 | Homo sapiens | ||
| 4 | M (M) | beta-D-mannopyranose-(3-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | ||||
| 5 | N, P, Q (A, H, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | O, R (A, K) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 7 | S (E) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, D, G, J: -1 - 181 (UniProt: Q30069)
| PDB | External Database | Details |
|---|---|---|
| Cys 72 | Ile 75 | engineered mutation |
| Ser 182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 180762.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 875.9 | |
| All* | Total formula weight | 182224.5 |
