8VDU

Crystal structure of hybrid insulin peptide (InsC8-15-IAPP74-80) bound to HLA-DQ8

Summary for 8VDU

Entry DOI	10.2210/pdb8vdu/pdb
Related	8VCX 8VCY 8VD0 8VD2 8VDD
Descriptor	MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, Hybrid insulin peptide (HIP; InsC8-15-IAPP74-80), ... (7 entities in total)
Functional Keywords	pmhc ii complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	182224.53
Authors	Tran, T.M.,Lim, J.J.,Loh, T.Y.,Mannering, I.S.,Rossjohn, J.,Reid, H.H. (deposition date: 2023-12-17, release date: 2024-08-07, Last modification date: 2024-09-04)
Primary citation	Tran, M.T.,Lim, J.J.,Loh, T.J.,Mannering, S.I.,Rossjohn, J.,Reid, H.H. A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8. J.Biol.Chem., 300:107612-107612, 2024 Cited by PubMed: 39074636 DOI: 10.1016/j.jbc.2024.107612 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation