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PDB: 263 件
1BFT
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STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
分子名称: NUCLEAR FACTOR NF-KAPPA-B P65
著者Huang, D.B, Huxford, T, Chen, Y.Q, Ghosh, G.
登録日1997-09-12
公開日1998-01-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1BFS
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BU of 1bfs by Molmil
STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
分子名称: NUCLEAR FACTOR NF-KAPPA-B P50
著者Huang, D.B, Huxford, T, Chen, Y.Q, Ghosh, G.
登録日1997-09-12
公開日1998-01-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1Y8X
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Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1
分子名称: Ubiquitin-activating enzyme E1C, Ubiquitin-conjugating enzyme E2 M
著者Huang, D.T, Paydar, A, Zhuang, M, Waddell, M.B, Holton, J.M, Schulman, B.A.
登録日2004-12-13
公開日2005-02-08
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
2NVU
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Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, ...
著者Huang, D.T, Hunt, H.W, Zhuang, M, Ohi, M.D, Holton, J.M, Schulman, B.A.
登録日2006-11-13
公開日2007-01-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
1OOA
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BU of 1ooa by Molmil
CRYSTAL STRUCTURE OF NF-kB(p50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER
分子名称: Nuclear factor NF-kappa-B p105 subunit, RNA aptamer
著者Huang, D.B, Vu, D, Cassiday, L.A, Zimmerman, J.M, Maher III, L.J, Ghosh, G.
登録日2003-03-03
公開日2003-07-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.
Proc.Natl.Acad.Sci.USA, 100, 2003
1TT5
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Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
分子名称: Ubiquitin-conjugating enzyme E2 M, ZINC ION, amyloid protein-binding protein 1, ...
著者Huang, D.T, Miller, D.W, Mathew, R, Cassell, R, Holton, J.M, Roussel, M.F, Schulman, B.A.
登録日2004-06-21
公開日2004-09-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
3FN1
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E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
分子名称: NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F
著者Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A.
登録日2008-12-22
公開日2009-03-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
1SGS
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Crystal structure of a free kB DNA
分子名称: CALCIUM ION, kB DNA
著者Huang, D.B, Phelps, C.B, Fusco, A.J, Ghosh, G.
登録日2004-02-24
公開日2004-03-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB.
J.Mol.Biol., 346, 2005
1GJI
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BU of 1gji by Molmil
Crystal structure of c-Rel bound to DNA
分子名称: C-REL PROTO-ONCOGENE PROTEIN, IL-2 CD28RE DNA
著者Huang, D.B, Chen, Y.Q, Ruetsche, M, Phelps, C.B, Ghosh, G.
登録日2001-05-30
公開日2002-05-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.
Structure, 9, 2001
1WTL
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BU of 1wtl by Molmil
COMPARISON OF CRYSTAL STRUCTURES OF TWO HOMOLOGOUS PROTEINS: STRUCTURAL ORIGIN OF ALTERED DOMAIN INTERACTIONS IN IMMUNOGLOBULIN LIGHT CHAIN DIMERS
分子名称: BENCE-JONES PROTEIN MCG (LIGHT CHAIN)
著者Huang, D.B, Chang, C.H, Schiffer, M.
登録日1994-06-08
公開日1994-11-01
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Comparison of crystal structures of two homologous proteins: structural origin of altered domain interactions in immunoglobulin light-chain dimers.
Biochemistry, 33, 1994
1ZKA
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BU of 1zka by Molmil
NF-kB RelB forms an intertwined homodimer, Y300S mutant
分子名称: Transcription factor RelB
著者Huang, D.B, Vu, D, Ghosh, G.
登録日2005-05-02
公開日2005-05-10
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献NF-kappaB RelB forms an intertwined homodimer.
Structure, 13, 2005
1ZK9
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BU of 1zk9 by Molmil
NF-kB RelB forms an intertwined homodimer
分子名称: Transcription factor RelB
著者Huang, D.B, Vu, D, Ghosh, G.
登録日2005-05-02
公開日2005-05-10
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献NF-kappaB RelB Forms an Intertwined Homodimer.
Structure, 13, 2005
4JHB
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BU of 4jhb by Molmil
Crystal structure of RelB double mutants: Y300F/I335F
分子名称: Transcription factor RelB
著者Huang, D.B, Vu, D, Ghosh, G.
登録日2013-03-04
公開日2013-09-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Crystal structure of RelB double mutants: Y300F/I335F
TO BE PUBLISHED
4JGM
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BU of 4jgm by Molmil
Crystal structure of RelB double mutants: Y300F/I335V
分子名称: Transcription factor RelB
著者Huang, D.B, Vu, D, Ghosh, G.
登録日2013-03-01
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A structural basis for selective dimerization by NF-kappa B RelB.
J.Mol.Biol., 425, 2013
5J3X
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Structure of c-CBL Y371F
分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, ZINC ION
著者Huang, D.T, Buetow, L, Dou, H.
登録日2016-03-31
公開日2016-09-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
3JSS
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BU of 3jss by Molmil
Crystal structure of a mutant RelB dimerization domain
分子名称: Transcription factor RelB
著者Vu, D, Huang, D.B, Ghosh, G.
登録日2009-09-10
公開日2010-11-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A structural basis for selective dimerization by NF-kappa B RelB.
J.Mol.Biol., 425, 2013
3JUZ
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BU of 3juz by Molmil
Crystal structure of a mutant of RelB dimerization domain(M5)
分子名称: Transcription factor RelB
著者Vu, D, Huang, D.B, Ghosh, G.
登録日2009-09-15
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Instability of the RelB dimerization domain is functionally important
To be Published
1ZWV
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BU of 1zwv by Molmil
Solution Structure of the subunit binding domain (hbSBD) of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase
分子名称: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
著者Chang, C.F, Chuang, D.T, Huang, T.h.
登録日2005-06-06
公開日2005-06-21
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution Structure of the subunit binding domain (hbSBD) of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase
to be published
7AHY
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BU of 7ahy by Molmil
Crystal structure of Western clawed frog MDM2 RING domain homodimer
分子名称: E3 ubiquitin-protein ligase Mdm2, ZINC ION
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.532 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
4V3K
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BU of 4v3k by Molmil
RNF38-UbcH5B-UB complex
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
著者Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3L
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RNF38-UB-UbcH5B-Ub complex
分子名称: 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF38, POLYUBIQUITIN-C, ...
著者Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
1K8O
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BU of 1k8o by Molmil
Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human, Mitochondrial Branched-Chain alpha-Ketoacid Dehydrogenase
分子名称: E2 component of Branched-Chain alpha-Ketoacid Dehydrogenase
著者Chang, C.-F, Chou, H.-T, Chuang, J.L, Chuang, D.T, Huang, T.-h.
登録日2001-10-24
公開日2001-11-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex
J.Biol.Chem., 277, 2002
1K8M
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Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human, Mitochondrial Branched-Chain alpha-Ketoacid Dehydrogenase
分子名称: E2 component of Branched-Chain alpha-Ketoacid Dehydrogenase
著者Chang, C.-F, Chou, H.-T, Chuang, J.L, Chuang, D.T, Huang, T.-h.
登録日2001-10-24
公開日2001-11-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex
J.Biol.Chem., 277, 2002
6HPR
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BU of 6hpr by Molmil
Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub
分子名称: Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
著者Patel, A, Huang, D.T.
登録日2018-09-21
公開日2018-12-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.
J. Biol. Chem., 294, 2019
7OJX
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E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis
分子名称: 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), E3 ubiquitin-protein ligase RNF38, Polyubiquitin-B, ...
著者Majorek, K.A, Nakasone, M.A, Huang, D.T.
登録日2021-05-17
公開日2022-01-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Nat.Chem.Biol., 18, 2022

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件を2024-08-07に公開中

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