5TGZ
 
 | | Crystal Structure of the Human Cannabinoid Receptor CB1 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate, Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, ... | | 著者 | Hua, T, Vemuri, K, Pu, M, Qu, L, Han, G.W, Wu, Y, Zhao, S, Shui, W, Li, S, Korde, A, Laprairie, R.B, Stahl, E.L, Ho, J.H, Zvonok, N, Zhou, H, Kufareva, I, Wu, B, Zhao, Q, Hanson, M.A, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J. | | 登録日 | 2016-09-28 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of the Human Cannabinoid Receptor CB1.
Cell, 167, 2016
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5XRA
 | | Crystal structure of the human CB1 in complex with agonist AM11542 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, CHOLESTEROL, ... | | 著者 | Hua, T, Vemuri, K, Nikas, P.S, Laprairie, R.B, Wu, Y, Qu, L, Pu, M, Korde, A, Shan, J, Ho, J.H, Han, G.W, Ding, K, Li, X, Liu, H, Hanson, M.A, Zhao, S, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J. | | 登録日 | 2017-06-08 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
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5XR8
 | | Crystal structure of the human CB1 in complex with agonist AM841 | | 分子名称: | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, CHOLESTEROL, Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, ... | | 著者 | Hua, T, Vemuri, K, Nikas, P.S, Laprairie, R.B, Wu, Y, Qu, L, Pu, M, Korde, A, Shan, J, Ho, J.H, Han, G.W, Ding, K, Li, X, Liu, H, Hanson, M.A, Zhao, S, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J. | | 登録日 | 2017-06-07 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Crystal structures of agonist-bound human cannabinoid receptor CB1.
Nature, 547, 2017
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6KPG
 | | Cryo-EM structure of CB1-G protein complex | | 分子名称: | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hua, T, Li, X.T, Wu, L.J, Makriyannis, A, Wang, Y.X, Shen, L, Liu, Z.J. | | 登録日 | 2019-08-15 | | 公開日 | 2020-02-12 | | 最終更新日 | 2020-03-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
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4FC7
 | | Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR | | 分子名称: | COENZYME A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Peroxisomal 2,4-dienoyl-CoA reductase | | 著者 | Hua, T, Wu, D, Wang, J, Shaw, N, Liu, Z.-J. | | 登録日 | 2012-05-24 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids
J.Biol.Chem., 287, 2012
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4FC6
 | | Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR | | 分子名称: | HEXANOYL-COENZYME A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Peroxisomal 2,4-dienoyl-CoA reductase | | 著者 | Hua, T, Wu, D, Wang, J, Shaw, N, Liu, Z.-J. | | 登録日 | 2012-05-24 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids
J.Biol.Chem., 287, 2012
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2MI8
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8WRZ
 | | Cry-EM structure of cannabinoid receptor-arrestin 2 complex | | 分子名称: | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Beta-arrestin-1, Soluble cytochrome b562,Cannabinoid receptor 1, ... | | 著者 | Wang, Y.X, Wang, T, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2023-10-16 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of cannabinoid receptor CB1-beta-arrestin complex.
Protein Cell, 15, 2024
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8XQT
 | | Structure of human class T GPCR TAS2R14-Gi complex. | | 分子名称: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQO
 | | Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQR
 | | Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | | 分子名称: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQS
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | | 分子名称: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQN
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8YKY
 | | Structure of human class T GPCR TAS2R14-Ggustducin complex with agonist 28.1 | | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, G alpha gustducin protein, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-03-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQP
 | | Structure of human class T GPCR TAS2R14-Gustducin complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQL
 | | Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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7V6A
 | | Cry-EM structure of M4-c110-G protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T. | | 登録日 | 2021-08-20 | | 公開日 | 2022-05-11 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
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7V69
 | | Cryo-EM structure of a class A GPCR-G protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T. | | 登録日 | 2021-08-20 | | 公開日 | 2022-05-11 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
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7V68
 | | An Agonist and PAM-bound Class A GPCR with Gi protein complex structure | | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wang, J.J, Wu, L.J, Wu, M, Hua, T, Liu, Z.J, Wang, T. | | 登録日 | 2021-08-20 | | 公開日 | 2022-05-11 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
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7V3Z
 | | Structure of cannabinoid receptor type 1(CB1) | | 分子名称: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, CHOLESTEROL, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Liu, Z.J, Shen, L, Hua, T, Yao, D.Q, Wu, L.J. | | 登録日 | 2021-08-12 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.
J.Am.Chem.Soc., 143, 2021
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8GUS
 | | Cryo-EM structure of HU-CB2-G protein complex | | 分子名称: | Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. | | 登録日 | 2022-09-13 | | 公開日 | 2023-05-10 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
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8GUQ
 | | Cryo-EM structure of CB2-G protein complex | | 分子名称: | Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. | | 登録日 | 2022-09-13 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
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8GUT
 | | Cryo-EM structure of LEI-CB2-Gi complex | | 分子名称: | 1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Li, X.T, Chang, H, Wu, L.J. | | 登録日 | 2022-09-13 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
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8GUR
 | | Cryo-EM structure of CP-CB2-G protein complex | | 分子名称: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. | | 登録日 | 2022-09-13 | | 公開日 | 2023-05-10 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
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7XY7
 | | Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | | 登録日 | 2022-05-31 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex.
Sci Adv, 8, 2022
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