5I94
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![BU of 5i94 by Molmil](/molmil-images/mine/5i94) | Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019 | Descriptor: | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | Authors: | Huang, Q, Cerione, R. | Deposit date: | 2016-02-19 | Release date: | 2016-05-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.983 Å) | Cite: | Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
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5T8L
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![BU of 5t8l by Molmil](/molmil-images/mine/5t8l) | |
5T8N
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![BU of 5t8n by Molmil](/molmil-images/mine/5t8n) | |
2LYO
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![BU of 2lyo by Molmil](/molmil-images/mine/2lyo) | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 90% ACETONITRILE-WATER | Descriptor: | ACETONITRILE, LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-06 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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3LYO
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![BU of 3lyo by Molmil](/molmil-images/mine/3lyo) | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 95% ACETONITRILE-WATER | Descriptor: | ACETONITRILE, LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-11 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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3M7F
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![BU of 3m7f by Molmil](/molmil-images/mine/3m7f) | Crystal structure of the Nedd4 C2/Grb10 SH2 complex | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10 | Authors: | Huang, Q, Szebenyi, M. | Deposit date: | 2010-03-16 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4. J.Biol.Chem., 285, 2010
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4LYO
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![BU of 4lyo by Molmil](/molmil-images/mine/4lyo) | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN NEAT ACETONITRILE, THEN BACK-SOAKED IN WATER | Descriptor: | LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-11 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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1EV7
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![BU of 1ev7 by Molmil](/molmil-images/mine/1ev7) | CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI | Descriptor: | TYPE IIE RESTRICTION ENDONUCLEASE NAEI | Authors: | Huai, Q, Colandene, J.D, Chen, Y, Luo, F, Zhao, Y. | Deposit date: | 2000-04-19 | Release date: | 2000-10-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase. EMBO J., 19, 2000
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8DZT
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![BU of 8dzt by Molmil](/molmil-images/mine/8dzt) | Crystal structure of human Sar1aH79G mutant | Descriptor: | CALCIUM ION, GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8E0A
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![BU of 8e0a by Molmil](/molmil-images/mine/8e0a) | Crystal structure of human Sar1b | Descriptor: | GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8E0D
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![BU of 8e0d by Molmil](/molmil-images/mine/8e0d) | Crystal structure of human Sar1bE140D | Descriptor: | GTP-binding protein SAR1b, GUANOSINE-5',3'-TETRAPHOSPHATE | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.981 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8E0H
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![BU of 8e0h by Molmil](/molmil-images/mine/8e0h) | Crystal structure of human Sar1aD104/D140A double mutant | Descriptor: | GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE | Authors: | Huang, Q. | Deposit date: | 2022-08-09 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8DZO
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![BU of 8dzo by Molmil](/molmil-images/mine/8dzo) | Crystal structure of human Sar1T39N mutant | Descriptor: | CALCIUM ION, GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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5FI7
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![BU of 5fi7 by Molmil](/molmil-images/mine/5fi7) | Crystal structure of human GAC in complex with inhibitor UPGL_00015: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide | Descriptor: | 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | Authors: | Huang, Q, Cerione, R. | Deposit date: | 2015-12-22 | Release date: | 2016-05-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
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5FI6
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![BU of 5fi6 by Molmil](/molmil-images/mine/5fi6) | Crystal structure of human GAC in complex with inhibitor UPGL_00011: 2-phenyl-~{N}-[5-[[(3~{S})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide | Descriptor: | 2-phenyl-~{N}-[5-[[(3~{S})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | Authors: | Huang, Q, Cerione, R. | Deposit date: | 2015-12-22 | Release date: | 2016-05-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
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8E0B
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![BU of 8e0b by Molmil](/molmil-images/mine/8e0b) | Crystal structure of human Sar1bT39N | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, Sar1bT39N | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2023-08-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.212 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8E0C
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![BU of 8e0c by Molmil](/molmil-images/mine/8e0c) | Crystal structure of human Sar1bH79G | Descriptor: | GTP-binding protein SAR1b, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2023-08-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.993 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8DZN
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![BU of 8dzn by Molmil](/molmil-images/mine/8dzn) | Crystal structure of human Sar1a in complex with GDP | Descriptor: | GTP-binding protein SAR1a, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION | Authors: | Huang, Q. | Deposit date: | 2022-08-08 | Release date: | 2023-08-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.107 Å) | Cite: | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
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8DZM
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5FI2
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![BU of 5fi2 by Molmil](/molmil-images/mine/5fi2) | Crystal structure of human GAC in complex with inhibitor UPGL_00009: 2-phenyl-~{N}-[5-[[(3~{R})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol- 2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide | Descriptor: | 2-phenyl-~{N}-[5-[[(3~{R})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | Authors: | Huang, Q, Cerione, R. | Deposit date: | 2015-12-22 | Release date: | 2016-05-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
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5D3O
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8ETD
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![BU of 8etd by Molmil](/molmil-images/mine/8etd) | Crystal Structure of Schizosaccharomyces pombe Rho1 | Descriptor: | GTP-binding protein rho1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Huang, Q, Xie, J, Seetharaman, J. | Deposit date: | 2022-10-16 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases. Biology (Basel), 11, 2022
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1PTW
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1OYN
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![BU of 1oyn by Molmil](/molmil-images/mine/1oyn) | Crystal structure of PDE4D2 in complex with (R,S)-rolipram | Descriptor: | ROLIPRAM, ZINC ION, cAMP-specific phosphodiesterase PDE4D2 | Authors: | Huai, Q, Wang, H, Sun, Y, Kim, H.Y, Liu, Y, Ke, H. | Deposit date: | 2003-04-05 | Release date: | 2003-07-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity Structure, 11, 2003
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1Q9M
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![BU of 1q9m by Molmil](/molmil-images/mine/1q9m) | Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity | Descriptor: | ROLIPRAM, ZINC ION, cAMP-specific phosphodiesterase PDE4D2 | Authors: | Huai, Q, Wang, H, Sun, Y, Kim, H.Y, Liu, Y, Ke, H. | Deposit date: | 2003-08-25 | Release date: | 2003-09-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity Structure, 11, 2003
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