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PDB: 13 件
8SG5
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Cytochrome P450 (CYP) 3A5 crystallized with clotrimazole
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A5, DODECYL NONA ETHYLENE GLYCOL ETHER, ...
著者Hsu, M.H, Johnson, E.F.
登録日2023-04-11
公開日2023-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4.
Drug Metab.Dispos., 51, 2023
8SPD
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Cytochrome P450 (CYP) 3A4 crystallized with clotrimazole
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M.H, Johnson, E.F.
登録日2023-05-02
公開日2023-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4.
Drug Metab.Dispos., 51, 2023
5TFT
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Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex
分子名称: (4S)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Hsu, M.H, Johnson, E.F.
登録日2016-09-26
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
5TFU
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Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex
分子名称: (4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Hsu, M.H, Johnson, E.F.
登録日2016-09-26
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
6MJM
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Substrate Free Cytochrome P450 3A5 (CYP3A5)
分子名称: Cytochrome P450 3A5, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M.H, Johnson, E.F.
登録日2018-09-21
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4.
J.Biol.Chem., 294, 2019
2PG6
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Crystal Structure of Human Microsomal P450 2A6 L240C/N297Q
分子名称: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
登録日2007-04-06
公開日2007-07-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
1ZJF
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12mer-spd-P4N
分子名称: 5'-D(*AP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*CP*CP*CP*GP*CP*CP*CP*C)-3'
著者Dohm, J.A, Hsu, M.H, Hwu, J.R, Huang, R.C, Moudrianakis, E.N, Lattman, E.E, Gittis, A.G.
登録日2005-04-28
公開日2005-05-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Influence of Ions, Hydration, and the Transcriptional Inhibitor P4N on the Conformations of the Sp1 Binding Site.
J.Mol.Biol., 349, 2005
1ZJG
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13mer-co
分子名称: 5'-D(*AP*TP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*CP*CP*CP*GP*CP*CP*CP*CP*A)-3', COBALT HEXAMMINE(III), ...
著者Dohm, J.A, Hsu, M.H, Hwu, J.R, Huang, R.C, Moudrianakis, E.N, Lattman, E.E, Gittis, A.G.
登録日2005-04-28
公開日2005-05-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Influence of Ions, Hydration, and the Transcriptional Inhibitor P4N on the Conformations of the Sp1 Binding Site.
J.Mol.Biol., 349, 2005
1Z11
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Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound
分子名称: METHOXSALEN, PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450, ...
著者Yano, J.K, Hsu, M.H, Griffin, K.J, Stout, C.D, Johnson, E.F.
登録日2005-03-02
公開日2005-08-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
Nat.Struct.Mol.Biol., 12, 2005
1Z10
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Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound
分子名称: COUMARIN, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Yano, J.K, Hsu, M.H, Griffin, K.J, Stout, C.D, Johnson, E.F.
登録日2005-03-02
公開日2005-08-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
Nat.Struct.Mol.Biol., 12, 2005
1ZJE
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BU of 1zje by Molmil
12mer-spd
分子名称: 5'-D(*AP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*CP*CP*CP*GP*CP*CP*CP*C)-3'
著者Dohm, J.A, Hsu, M.H, Hwu, J.R, Huang, R.C, Moudrianakis, E.N, Lattman, E.E, Gittis, A.G.
登録日2005-04-28
公開日2005-05-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Influence of Ions, Hydration, and the Transcriptional Inhibitor P4N on the Conformations of the Sp1 Binding Site.
J.Mol.Biol., 349, 2005
2PG5
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BU of 2pg5 by Molmil
Crystal Structure of Human Microsomal P450 2A6 N297Q
分子名称: 1,2-ETHANEDIOL, Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
登録日2007-04-06
公開日2007-07-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2PG7
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Crystal Structure of Human Microsomal P450 2A6 N297Q/I300V
分子名称: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
登録日2007-04-06
公開日2007-07-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007

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