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PDB: 54 件
7VBF
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1.3 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 8.5
分子名称: Nucleoprotein
著者Zhou, X.L, Zhong, F.L, Li, J, Zhang, J.
登録日2021-08-31
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献1.3 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 8.5
To Be Published
7VBE
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1.6 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 5.0
分子名称: Nucleoprotein
著者Zhou, X.L, Zhong, F.L, Li, J, Zhang, J.
登録日2021-08-31
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献1.6 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 5.0
To Be Published
7XAX
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BU of 7xax by Molmil
Crystal structure of SARS coronavirus main protease in complex with Baicalei
分子名称: 3C-like proteinase nsp5, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
著者Zhou, X.L, Li, J, Zhang, J.
登録日2022-03-19
公開日2023-03-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of SARS coronavirus main protease in complex with Baicalei
To Be Published
7VVP
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Crystal structure of SARS-Cov-2 main protease in complex with PF07304814
分子名称: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
著者Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J.
登録日2021-11-07
公開日2022-08-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
J.Mol.Biol., 434, 2022
7VLQ
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Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P212121
分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
著者Zhou, X.L, Zhong, F.L, Lin, C, Zhang, J, Li, J.
登録日2021-10-05
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.939106 Å)
主引用文献Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
J.Virol., 96, 2022
7VLP
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Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P1211
分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, Replicase polyprotein 1a
著者Zhou, X.L, Zhong, F.L, Lin, C, Li, J, Zhang, J.
登録日2021-10-05
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.50251937 Å)
主引用文献Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
J.Virol., 96, 2022
7XRS
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Crystal structure of SARS-Cov-2 main protease in complex with inhibitor YH-53
分子名称: N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1a
著者Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J.
登録日2022-05-11
公開日2022-12-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor.
Viruses, 14, 2022
7WZV
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The structure of a Twitch Radical SAM Dehydrogenase SpeY
分子名称: (1~{S},2~{R},4~{S},5~{R})-2,4-bis(methylamino)-6-[(2~{S},3~{R},4~{S},6~{R})-6-methyl-3,4-bis(oxidanyl)oxan-2-yl]oxy-cyclohexane-1,3,5-triol, 1,2-ETHANEDIOL, 4Fe-4S cluster-binding domain-containing protein, ...
著者Zhou, J.H, Hou, X.L.
登録日2022-02-19
公開日2022-12-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.899313 Å)
主引用文献Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
7YRZ
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Crystal structure of HCoV 229E main protease in complex with PF07321332
分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
著者Zhou, Y.R, Zeng, P, Zhou, X.L, Lin, C, Zhang, J, Yin, X.S, Li, J.
登録日2022-08-11
公開日2023-08-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.
Biochem.Biophys.Res.Commun., 657, 2023
7DQZ
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Crystal structure of SARS 3C-like protease in apo form
分子名称: 3C-like proteinase
著者Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J.
登録日2020-12-24
公開日2021-09-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus.
J.Virol., 96, 2022
8WZQ
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Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with CCF0058981
分子名称: 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(1~{H}-imidazol-5-yl)phenyl]ethanamide, 3C-like proteinase nsp5
著者Zou, X.F, Jiang, H.H, Zhou, X.L, Zhang, J, Li, J.
登録日2023-11-02
公開日2024-04-17
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Crystal structure of SARS-CoV-2 main protease (M pro ) mutants in complex with the non-covalent inhibitor CCF0058981.
Biochem.Biophys.Res.Commun., 692, 2024
8WZP
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Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with CCF0058981
分子名称: 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(1~{H}-imidazol-5-yl)phenyl]ethanamide, 3C-like proteinase nsp5
著者Jiang, H.H, Zou, X.F, Zhou, X.L, Zhang, J, Li, J.
登録日2023-11-02
公開日2024-04-17
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal structure of SARS-CoV-2 main protease (M pro ) mutants in complex with the non-covalent inhibitor CCF0058981.
Biochem.Biophys.Res.Commun., 692, 2024
7DR8
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BU of 7dr8 by Molmil
Crystal structure of MERS-CoV 3CL protease in spacegroup P212121
分子名称: 3C-like proteinase
著者Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J.
登録日2020-12-26
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.338149 Å)
主引用文献Crystal structure of MERS-CoV 3CL protease in spacegroup P212121
To Be Published
7DRA
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BU of 7dra by Molmil
Crystal structure of MERS-CoV 3CL protease (C148A) in spacegroup P212121,pH 9.0
分子名称: 3C-like proteinase
著者Zhang, Y.T, Zhou, X.L, Li, J, Zhang, J.
登録日2020-12-27
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.784097 Å)
主引用文献Crystal structure of MERS-CoV 3CL protease (C148A) in spacegroup P212121,pH 9.0
To Be Published
7EO7
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BU of 7eo7 by Molmil
Crystal structure of HCoV-NL63 3C-like protease in complex with an inhibitor Shikonin
分子名称: 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase
著者Gao, H.X, Zhang, Y.T, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J.
登録日2021-04-21
公開日2021-10-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.24916625 Å)
主引用文献Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus.
J.Virol., 96, 2022
7EO8
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BU of 7eo8 by Molmil
Crystal structure of SARS coronavirus main protease in complex with an inhibitor Shikonin
分子名称: 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase
著者Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J.
登録日2021-04-21
公開日2021-10-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2808516 Å)
主引用文献Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus.
J.Virol., 96, 2022
7E6R
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BU of 7e6r by Molmil
Crystal structure of HCoV-NL63 3C-like protease,pH5.6
分子名称: 3C-like proteinase
著者Gao, H.X, Zhang, Y.T, Zhong, F.L, Zhou, X.L, Li, J, Zhang, J.
登録日2021-02-23
公開日2021-10-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of human coronavirus NL63 main protease at different pH values
Acta Crystallogr.,Sect.F, 77, 2021
7E6L
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BU of 7e6l by Molmil
Crystal structure of HCoV-NL63 3C-like protease,pH5.0
分子名称: 3C-like proteinase
著者Gao, H.X, Zhang, Y.T, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J.
登録日2021-02-22
公開日2021-10-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.78037143 Å)
主引用文献Crystal structures of human coronavirus NL63 main protease at different pH values
Acta Crystallogr.,Sect.F, 77, 2021
7E6M
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BU of 7e6m by Molmil
Crystal structure of Human coronavirus NL63 3C-like protease
分子名称: 3C-like proteinase
著者Gao, H.X, Zhang, Y.T, Zhong, F.L, Zhou, X.L, Li, J, Zhang, J.
登録日2021-02-22
公開日2021-10-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.83445024 Å)
主引用文献Crystal structures of human coronavirus NL63 main protease at different pH values
Acta Crystallogr.,Sect.F, 77, 2021
7E6N
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BU of 7e6n by Molmil
Crystal structure of HCoV-NL63 3C-like protease,pH5.2
分子名称: 3C-like proteinase
著者Gao, H.X, Zhang, Y.T, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J.
登録日2021-02-22
公開日2021-10-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8413 Å)
主引用文献Crystal structures of human coronavirus NL63 main protease at different pH values
Acta Crystallogr.,Sect.F, 77, 2021
7VBD
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BU of 7vbd by Molmil
Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0
分子名称: Nucleoprotein
著者Zeng, P, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J.
登録日2021-08-31
公開日2022-08-31
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0
To Be Published
7YDG
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BU of 7ydg by Molmil
Crystal structure of human SARS2 catalytic domain with a disease related mutation
分子名称: Serine--tRNA ligase, mitochondrial
著者Wu, S, Li, P, Zhou, X.L, Fang, P.
登録日2022-07-04
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.
Nucleic Acids Res., 50, 2022
7YDF
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BU of 7ydf by Molmil
Crystal structure of human SARS2 catalytic domain
分子名称: Serine--tRNA ligase, mitochondrial
著者Wu, S, Li, P, Zhou, X.L, Fang, P.
登録日2022-07-04
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.
Nucleic Acids Res., 50, 2022
7WQI
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BU of 7wqi by Molmil
Crystal structure of SARS coronavirus main protease in complex with PF07304814
分子名称: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
著者Lin, C, Zhong, F.L, Zhou, X.L, Zeng, P, Zhang, J, Li, J.
登録日2022-01-25
公開日2023-01-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal structure of SARS coronavirus main protease in complex with PF07304814
To Be Published
7WQH
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BU of 7wqh by Molmil
Crystal structure of HCoV-NL63 main protease with PF07304814
分子名称: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
著者Zhong, F.L, Zhou, X.L, Lin, C, Zeng, P, Li, J, Zhang, J.
登録日2022-01-25
公開日2022-08-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
J.Mol.Biol., 434, 2022

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件を2024-08-28に公開中

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