7XAX

Crystal structure of SARS coronavirus main protease in complex with Baicalei

Summary for 7XAX

• Entry DOI: 10.2210/pdb7xax/pdb
• Descriptor: 3C-like proteinase nsp5, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (3 entities in total)
• Functional Keywords: sars, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 68023.51

Authors

Zhou, X.L.,Li, J.,Zhang, J. (deposition date: 2022-03-19, release date: 2023-03-22, Last modification date: 2024-10-02)

Primary citation

Feng, J.,Li, D.,Zhang, J.,Yin, X.,Li, J.
Crystal structure of SARS-CoV 3C-like protease with baicalein.
Biochem.Biophys.Res.Commun., 611:190-194, 2022

PubMed Abstract: The 3C-like protease (M, 3CL) plays a key role in the replication process in coronaviruses (CoVs). The M is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV M in vitro experiments. In this study, we resolved the SARS-CoV M with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.

PubMed: 35490659
DOI: 10.1016/j.bbrc.2022.04.086

Experimental method

X-RAY DIFFRACTION (2.25 Å)