7VLQ
Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P212121
Summary for 7VLQ
Entry DOI | 10.2210/pdb7vlq/pdb |
Descriptor | 3C-like proteinase, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total) |
Functional Keywords | viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 67414.86 |
Authors | Zhou, X.L.,Zhong, F.L.,Lin, C.,Zhang, J.,Li, J. (deposition date: 2021-10-05, release date: 2022-04-06, Last modification date: 2023-11-29) |
Primary citation | Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,Yang, Y.,Zhang, Y.,Yu, B.,Fan, X.,McCormick, P.J.,Fu, R.,Fu, Y.,Jiang, H.,Zhang, J. Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J.Virol., 96:e0201321-e0201321, 2022 Cited by PubMed: 35389231DOI: 10.1128/jvi.02013-21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93910601486 Å) |
Structure validation
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