6VV3
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![BU of 6vv3 by Molmil](/molmil-images/mine/6vv3) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1358 | 分子名称: | 2-[(4-amino-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl)ethyl]acetamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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6VUS
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![BU of 6vus by Molmil](/molmil-images/mine/6vus) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT379 | 分子名称: | 2-[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(diethylamino)ethyl]acetamide, GLYCEROL, N-acetyltransferase Eis | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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6VV2
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![BU of 6vv2 by Molmil](/molmil-images/mine/6vv2) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1348 | 分子名称: | 2-{[3-(piperidin-1-yl)propyl]sulfanyl}-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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6VUT
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![BU of 6vut by Molmil](/molmil-images/mine/6vut) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT392 | 分子名称: | 2-[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(morpholin-4-yl)ethyl]acetamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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6VUX
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![BU of 6vux by Molmil](/molmil-images/mine/6vux) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT388 | 分子名称: | 2-{[(7S)-4-amino-7-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-[2-(piperidin-1-yl)ethyl]acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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4V5K
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![BU of 4v5k by Molmil](/molmil-images/mine/4v5k) | Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Ng, C.L, Lang, K, Meenan, N.A.G, Sharma, A, Kelley, A.C, Kleanthous, C, Ramakrishnan, V. | 登録日 | 2010-05-29 | 公開日 | 2014-07-09 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Basis for 16S Ribosomal RNA Cleavage by the Cytotoxic Domain of Colicin E3. Nat.Struct.Mol.Biol., 17, 2010
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8IIC
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8IIB
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![BU of 8iib by Molmil](/molmil-images/mine/8iib) | Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) | 分子名称: | CADMIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Fang, X, Lu, G, Hou, C, Gong, P. | 登録日 | 2023-02-24 | 公開日 | 2023-06-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
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3P65
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![BU of 3p65 by Molmil](/molmil-images/mine/3p65) | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | 分子名称: | CHLORIDE ION, GOLD 3+ ION, GOLD ION, ... | 著者 | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | 登録日 | 2010-10-11 | 公開日 | 2011-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol, 6, 2011
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3P68
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![BU of 3p68 by Molmil](/molmil-images/mine/3p68) | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | 分子名称: | GOLD 3+ ION, Lysozyme C | 著者 | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | 登録日 | 2010-10-11 | 公開日 | 2011-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol, 6, 2011
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3P66
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![BU of 3p66 by Molmil](/molmil-images/mine/3p66) | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | 分子名称: | GOLD 3+ ION, Lysozyme C | 著者 | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | 登録日 | 2010-10-11 | 公開日 | 2011-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol, 6, 2011
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3P4Z
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![BU of 3p4z by Molmil](/molmil-images/mine/3p4z) | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | 分子名称: | CHLORIDE ION, GOLD 3+ ION, GOLD ION, ... | 著者 | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | 登録日 | 2010-10-07 | 公開日 | 2011-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol, 6, 2011
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3P64
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![BU of 3p64 by Molmil](/molmil-images/mine/3p64) | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | 分子名称: | CHLORIDE ION, GOLD 3+ ION, GOLD ION, ... | 著者 | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | 登録日 | 2010-10-11 | 公開日 | 2011-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol, 6, 2011
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4RVH
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![BU of 4rvh by Molmil](/molmil-images/mine/4rvh) | Crystal structure of MtmC in complex with SAH and TDP-4-keto-D-olivose | 分子名称: | D-mycarose 3-C-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2015-05-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVG
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![BU of 4rvg by Molmil](/molmil-images/mine/4rvg) | Crystal structure of MtmC in complex with SAM and TDP | 分子名称: | ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ... | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVD
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![BU of 4rvd by Molmil](/molmil-images/mine/4rvd) | Crystal structure of MtmC in complex with SAM | 分子名称: | ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ... | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2015-05-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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5TVJ
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![BU of 5tvj by Molmil](/molmil-images/mine/5tvj) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and inhibitor 2k*: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium | 分子名称: | 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, CHLORIDE ION, COENZYME A, ... | 著者 | Gajadeera, C.S, Garzan, A, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2016-11-09 | 公開日 | 2017-03-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors. ACS Infect Dis, 3, 2017
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4RVF
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![BU of 4rvf by Molmil](/molmil-images/mine/4rvf) | Crystal structure of MtmC in complex with TDP | 分子名称: | D-mycarose 3-C-methyltransferase, THYMIDINE-5'-DIPHOSPHATE, ZINC ION | 著者 | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | 登録日 | 2014-11-26 | 公開日 | 2015-01-28 | 最終更新日 | 2015-05-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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5D3C
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![BU of 5d3c by Molmil](/molmil-images/mine/5d3c) | Crystal structure of a double mutant catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470 | 分子名称: | CALCIUM ION, Macrophage metalloelastase, N-[(2R)-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}-4-(hydroxyamino)-4-oxobutanoyl]-L-alpha-glutamyl-L-alpha-glutamine, ... | 著者 | Rouanet-Mehouas, C, Devel, L, Dive, V, Stura, E.A. | 登録日 | 2015-08-06 | 公開日 | 2016-08-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.314 Å) | 主引用文献 | Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity. J. Med. Chem., 60, 2017
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6KSQ
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![BU of 6ksq by Molmil](/molmil-images/mine/6ksq) | |
4UHP
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![BU of 4uhp by Molmil](/molmil-images/mine/4uhp) | Crystal structure of the pyocin AP41 DNase-Immunity complex | 分子名称: | BACTERIOCIN IMMUNITY PROTEIN, LARGE COMPONENT OF PYOCIN AP41 | 著者 | Joshi, A, Chen, S, Wojdyla, J.A, Kaminska, R, Kleanthous, C. | 登録日 | 2015-03-25 | 公開日 | 2015-08-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of the Ultra-High Affinity Protein-Protein Complexes of Pyocins S2 and Ap41 and Their Cognate Immunity Proteins from Pseudomonas Aeruginosa J.Mol.Biol., 427, 2015
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4UHQ
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![BU of 4uhq by Molmil](/molmil-images/mine/4uhq) | Crystal structure of the pyocin AP41 DNase | 分子名称: | CITRIC ACID, LARGE COMPONENT OF PYOCIN AP41, NICKEL (II) ION | 著者 | Joshi, A, Chen, S, Wojdyla, J.A, Kaminska, R, Kleanthous, C. | 登録日 | 2015-03-25 | 公開日 | 2015-08-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures of the Ultra-High Affinity Protein-Protein Complexes of Pyocins S2 and Ap41 and Their Cognate Immunity Proteins from Pseudomonas Aeruginosa J.Mol.Biol., 427, 2015
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4UDM
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7QA9
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![BU of 7qa9 by Molmil](/molmil-images/mine/7qa9) | 10bp DNA/DNA duplex | 分子名称: | DNA (5'-D(*CP*CP*AP*TP*TP*AP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*TP*GP*G)-3') | 著者 | Li, Q, Trajkovski, M, Fan, C, Chen, J, Zhou, Y, Lu, K, Li, H, Su, X, Xi, Z, Plavec, J, Zhou, C. | 登録日 | 2021-11-16 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | 4'-SCF 3 -Labeling Constitutes a Sensitive 19 F NMR Probe for Characterization of Interactions in the Minor Groove of DNA. Angew.Chem.Int.Ed.Engl., 61, 2022
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7NG9
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![BU of 7ng9 by Molmil](/molmil-images/mine/7ng9) | |