5D3C

Crystal structure of a double mutant catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470

Summary for 5D3C

DescriptorMacrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmmp12, human, macrophage metalloelastase, rxp470, hydroxamate, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationSecreted, extracellular space, extracellular matrix  P39900
Total number of polymer chains1
Total molecular weight18466.68
Authors
Rouanet-Mehouas, C.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2015-08-06, release date: 2016-08-17, Last modification date: 2017-01-25)
Primary citation
Rouanet-Mehouas, C.,Czarny, B.,Beau, F.,Cassar-Lajeunesse, E.,Stura, E.A.,Dive, V.,Devel, L.
Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity.
J. Med. Chem., 60:403-414, 2017
PubMed: 27996256 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.6b01420
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.314 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1900003.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution