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6VV2

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1348

Summary for 6VV2
Entry DOI10.2210/pdb6vv2/pdb
DescriptorN-acetyltransferase Eis, 2-{[3-(piperidin-1-yl)propyl]sulfanyl}-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amine, DI(HYDROXYETHYL)ETHER, ... (9 entities in total)
Functional Keywordsacetyltransferase, resistance, aminoglycoside, competitive, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains1
Total formula weight46806.55
Authors
Punetha, A.,Hou, C.,Ngo, H.X.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2020-02-16, release date: 2020-06-03, Last modification date: 2023-10-11)
Primary citationPunetha, A.,Ngo, H.X.,Holbrook, S.Y.L.,Green, K.D.,Willby, M.J.,Bonnett, S.A.,Krieger, K.,Dennis, E.K.,Posey, J.E.,Parish, T.,Tsodikov, O.V.,Garneau-Tsodikova, S.
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis.
Acs Chem.Biol., 15:1581-1594, 2020
Cited by
PubMed: 32421305
DOI: 10.1021/acschembio.0c00184
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.95 Å)
Structure validation

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