1RFN
| HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE | Descriptor: | CALCIUM ION, P-AMINO BENZAMIDINE, PROTEIN (COAGULATION FACTOR IX), ... | Authors: | Hopfner, K.-P, Lang, A, Karcher, A, Sichler, K, Kopetzki, E, Brandstetter, H, Huber, R, Bode, W, Engh, R.A. | Deposit date: | 1999-04-19 | Release date: | 1999-09-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding. Structure Fold.Des., 7, 1999
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4WVY
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1F2U
| Crystal Structure of RAD50 ABC-ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAD50 ABC-ATPASE | Authors: | Hopfner, K.P, Karcher, A, Shin, D.S, Craig, L. | Deposit date: | 2000-05-29 | Release date: | 2000-08-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell(Cambridge,Mass.), 101, 2000
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1S8E
| Crystal structure of Mre11-3 | Descriptor: | MANGANESE (II) ION, exonuclease putative | Authors: | Hopfner, K.P. | Deposit date: | 2004-02-02 | Release date: | 2004-08-10 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and functional analysis of Mre11-3 Nucleic Acids Res., 32, 2004
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1II7
| Crystal structure of P. furiosus Mre11 with manganese and dAMP | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Mre11 nuclease, ... | Authors: | Hopfner, K.-P, Karcher, A, Craig, L, Woo, T.T, Carney, J.P, Tainer, J.A. | Deposit date: | 2001-04-20 | Release date: | 2001-05-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell(Cambridge,Mass.), 105, 2001
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1TGO
| THERMOSTABLE B TYPE DNA POLYMERASE FROM THERMOCOCCUS GORGONARIUS | Descriptor: | PROTEIN (THERMOSTABLE B DNA POLYMERASE) | Authors: | Hopfner, K.-P, Eichinger, A, Engh, R.A, Laue, F, Ankenbauer, W, Huber, R, Angerer, B. | Deposit date: | 1999-02-23 | Release date: | 1999-03-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius. Proc.Natl.Acad.Sci.USA, 96, 1999
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1F2T
| Crystal Structure of ATP-Free RAD50 ABC-ATPase | Descriptor: | RAD50 ABC-ATPASE | Authors: | Hopfner, K.P, Karcher, A, Shin, D.S, Craig, L. | Deposit date: | 2000-05-29 | Release date: | 2000-08-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell(Cambridge,Mass.), 101, 2000
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1II8
| Crystal structure of the P. furiosus Rad50 ATPase domain | Descriptor: | PHOSPHATE ION, Rad50 ABC-ATPase | Authors: | Hopfner, K.-P, Karcher, A, Craig, L, Woo, T.T, Carney, J.P, Tainer, J.A. | Deposit date: | 2001-04-20 | Release date: | 2001-05-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell(Cambridge,Mass.), 105, 2001
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1FXY
| COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG-CHLOROMETHYLKETONE | Descriptor: | COAGULATION FACTOR XA-TRYPSIN CHIMERA, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | Authors: | Hopfner, K.P, Kopetzki, E, Kresse, G.-B, Huber, R, Bode, W, Engh, R.A. | Deposit date: | 1998-04-22 | Release date: | 1998-06-17 | Last modified: | 2013-02-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | New enzyme lineages by subdomain shuffling. Proc.Natl.Acad.Sci.USA, 95, 1998
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3RA7
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2BA1
| Archaeal exosome core | Descriptor: | Archaeal exosome RNA binding protein CSL4, Archaeal exosome complex exonuclease RRP41, Archaeal exosome complex exonuclease RRP42, ... | Authors: | Hopfner, K.P, Buttner, K, Wenig, K. | Deposit date: | 2005-10-13 | Release date: | 2005-11-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural framework for the mechanism of archaeal exosomes in RNA processing. Mol.Cell, 20, 2005
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3PP3
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3PP4
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1L8D
| Rad50 coiled-coil Zn hook | Descriptor: | CITRIC ACID, DNA double-strand break repair rad50 ATPase, MERCURY (II) ION, ... | Authors: | Hopfner, K.P, Tainer, J.A. | Deposit date: | 2002-03-20 | Release date: | 2002-08-28 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature, 418, 2002
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1BUI
| Structure of the ternary microplasmin-staphylokinase-microplasmin complex: a proteinase-cofactor-substrate complex in action | Descriptor: | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, Plasminogen, Staphylokinase | Authors: | Parry, M.A.A, Fernandez-Catalan, C, Bergner, A, Huber, R, Hopfner, K, Schlott, B, Guehrs, K, Bode, W. | Deposit date: | 1998-09-04 | Release date: | 1999-09-02 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action. Nat.Struct.Biol., 5, 1998
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4WK1
| Crystal structure of Staphylococcus aureus PstA in complex with c-di-AMP | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CALCIUM ION, PstA | Authors: | Mueller, M, Hopfner, K.-P, Witte, G. | Deposit date: | 2014-10-01 | Release date: | 2014-11-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | c-di-AMP recognition by Staphylococcus aureus PstA. Febs Lett., 589, 2015
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4WK3
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7A08
| CryoEM Structure of cGAS Nucleosome complex | Descriptor: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | Authors: | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | Deposit date: | 2020-08-07 | Release date: | 2020-09-23 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587, 2020
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5N6I
| Crystal structure of mouse cGAS in complex with 39 bp DNA | Descriptor: | Cyclic GMP-AMP synthase, DNA (36-MER), DNA (37-MER), ... | Authors: | Andreeva, L, Kostrewa, D, Hopfner, K.-P. | Deposit date: | 2017-02-15 | Release date: | 2017-09-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature, 549, 2017
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6FML
| CryoEM Structure INO80core Nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin related protein 5, ... | Authors: | Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. | Deposit date: | 2018-01-31 | Release date: | 2018-04-25 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.34 Å) | Cite: | Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
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7NI5
| Human ATM kinase with bound inhibitor KU-55933 | Descriptor: | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, Serine-protein kinase ATM, ZINC ION | Authors: | Bartho, J.D, Stakyte, K, Rotheneder, M, Lammens, K, Hopfner, K.P. | Deposit date: | 2021-02-11 | Release date: | 2021-09-01 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
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5DA9
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11 | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Putative double-strand break protein, ... | Authors: | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | Deposit date: | 2015-08-19 | Release date: | 2016-03-02 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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5DAC
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with DNA | Descriptor: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), ... | Authors: | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | Deposit date: | 2015-08-19 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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3J16
| Models of ribosome-bound Dom34p and Rli1p and their ribosomal binding partners | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S24-A, ... | Authors: | Becker, T, Franckenberg, S, Wickles, S, Shoemaker, C.J, Anger, A.M, Armache, J.-P, Sieber, H, Ungewickell, C, Berninghausen, O, Daberkow, I, Karcher, A, Thomm, M, Hopfner, K.-P, Green, R, Beckmann, R. | Deposit date: | 2011-12-12 | Release date: | 2012-02-22 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature, 482, 2012
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6FHS
| CryoEM Structure of INO80core | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Arp5, ... | Authors: | Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. | Deposit date: | 2018-01-15 | Release date: | 2018-04-25 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.754 Å) | Cite: | Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
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