4E40
 
 | | The haptoglobin-hemoglobin receptor of Trypanosoma congolense | | Descriptor: | Putative uncharacterized protein | | Authors: | Higgins, M.K, Tkachenko, O, Brown, A, Reed, J, Carrington, M. | | Deposit date: | 2012-03-11 | | Release date: | 2013-01-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3BQI
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3BQL
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3BQK
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1TQQ
 | | Structure of TolC in complex with hexamminecobalt | | Descriptor: | COBALT HEXAMMINE(III), Outer membrane protein tolC | | Authors: | Higgins, M.K, Eswaran, J, Edwards, P.C, Schertler, G.F, Hughes, C, Koronakis, V. | | Deposit date: | 2004-06-18 | | Release date: | 2004-07-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC
J.Mol.Biol., 342, 2004
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1T5E
 | | The structure of MexA | | Descriptor: | D-Glyceraldehyde, GLYCEROL, Multidrug resistance protein mexA | | Authors: | Higgins, M.K, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V. | | Deposit date: | 2004-05-04 | | Release date: | 2004-05-18 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the periplasmic component of a bacterial drug efflux pump
Proc.Natl.Acad.Sci.USA, 101, 2004
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8A44
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8OVB
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4V3E
 | | The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | | Deposit date: | 2014-10-17 | | Release date: | 2014-12-17 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
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6ZYV
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6H5N
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8CDE
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8CDD
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4E6Z
 | | Tic22 from Plasmodium falciparum | | Descriptor: | Apicoplast TIC22, putative, GLYCEROL | | Authors: | Glaser, S, Higgins, M.K. | | Deposit date: | 2012-03-16 | | Release date: | 2012-10-10 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.1501 Å) | | Cite: | Tic22 is an essential chaperone required for protein import into the apicoplast.
J.Biol.Chem., 287, 2012
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5NST
 | | Human monoclonal antibody with a LAIR1 insertion | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy Chain of antibody MGD21, ... | | Authors: | Hsieh, F.-L, Higgins, M.K. | | Deposit date: | 2017-04-26 | | Release date: | 2017-10-04 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.
Elife, 6, 2017
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5MZA
 | | The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Erythrocyte membrane protein 1 (PfEMP1), ... | | Authors: | Lennartz, F, Higgins, M.K. | | Deposit date: | 2017-01-31 | | Release date: | 2017-03-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.
Cell Host Microbe, 21, 2017
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4X0J
 | | Trypanosoma brucei haptoglobin-haemoglobin receptor | | Descriptor: | Haptoglobin-hemoglobin receptor | | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | | Deposit date: | 2014-11-21 | | Release date: | 2014-12-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
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4X0L
 | | Human haptoglobin-haemoglobin complex | | Descriptor: | CACODYLATE ION, GLYCEROL, Haptoglobin, ... | | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | | Deposit date: | 2014-11-21 | | Release date: | 2014-12-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
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9F2D
 | | KIR2DL1 bound to RIFIN RBK21 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, KIR2DL protein, RIFIN RBK21, ... | | Authors: | Chamberlain, S.G, Higgins, M.K. | | Deposit date: | 2024-04-22 | | Release date: | 2025-04-09 | | Last modified: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (2.886 Å) | | Cite: | KIR2DL1 bound to RIFIN RBK21
Nature, 2025
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9HML
 | | KIR2DL1 bound to RIFIN PfKE01_040007400 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, KIR2DL protein, RIFIN PfKE01_040007400, ... | | Authors: | Chamberlain, S.G, Higgins, M.K. | | Deposit date: | 2024-12-09 | | Release date: | 2025-04-09 | | Last modified: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (2.171 Å) | | Cite: | RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1
Nature, 2025
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5HU6
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5JDO
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7ZXF
 | | Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.72 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWF
 | | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | | Descriptor: | 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.132 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWI
 | | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 32F3 heavy chain, 32F3 light chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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