9AWJ
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![BU of 9awj by Molmil](/molmil-images/mine/9awj) | Bovine adult muscle nAChR bound to ACh | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, ... | Authors: | Li, H, Hibbs, R.E. | Deposit date: | 2024-03-05 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Structural switch in acetylcholine receptors in developing muscle. Nature, 2024
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8EIZ
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![BU of 8eiz by Molmil](/molmil-images/mine/8eiz) | Cryo-EM structure of squid sensory receptor CRB1 | Descriptor: | N-benzyl-2-(2,6-dimethylanilino)-N,N-diethyl-2-oxoethan-1-aminium, Squid sensory receptor CRB1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, van Giesen, L, Kilian, P.B, Bai, X, Bellono, N.W, Hibbs, R.E. | Deposit date: | 2022-09-15 | Release date: | 2023-04-12 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Sensory specializations drive octopus and squid behaviour. Nature, 616, 2023
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8ESK
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![BU of 8esk by Molmil](/molmil-images/mine/8esk) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, resting-like state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-10-14 | Release date: | 2023-06-07 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F6Y
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![BU of 8f6y by Molmil](/molmil-images/mine/8f6y) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-11-17 | Release date: | 2023-06-07 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F6Z
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![BU of 8f6z by Molmil](/molmil-images/mine/8f6z) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-11-17 | Release date: | 2023-06-07 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F2S
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![BU of 8f2s by Molmil](/molmil-images/mine/8f2s) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-11-08 | Release date: | 2023-06-07 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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6PV8
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![BU of 6pv8 by Molmil](/molmil-images/mine/6pv8) | Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 | Descriptor: | (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E. | Deposit date: | 2019-07-19 | Release date: | 2019-09-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor. Neuron, 104, 2019
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6PV7
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![BU of 6pv7 by Molmil](/molmil-images/mine/6pv7) | Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E. | Deposit date: | 2019-07-19 | Release date: | 2019-09-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor. Neuron, 104, 2019
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7KOX
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![BU of 7kox by Molmil](/molmil-images/mine/7kox) | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the activated state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Baxter, L, Cabuco, R, Borek, D, Sine, S. | Deposit date: | 2020-11-10 | Release date: | 2021-03-17 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor. Cell, 184, 2021
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7KOQ
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![BU of 7koq by Molmil](/molmil-images/mine/7koq) | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | Deposit date: | 2020-11-09 | Release date: | 2021-03-17 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor. Cell, 184, 2021
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7KOO
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![BU of 7koo by Molmil](/molmil-images/mine/7koo) | Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-bungarotoxin isoform V31, ... | Authors: | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | Deposit date: | 2020-11-09 | Release date: | 2021-03-17 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor. Cell, 184, 2021
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7SMT
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![BU of 7smt by Molmil](/molmil-images/mine/7smt) | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine and carbachol | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E. | Deposit date: | 2021-10-26 | Release date: | 2022-03-09 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (2.56 Å) | Cite: | Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat.Struct.Mol.Biol., 29, 2022
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7SMS
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![BU of 7sms by Molmil](/molmil-images/mine/7sms) | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | Authors: | Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E. | Deposit date: | 2021-10-26 | Release date: | 2022-03-09 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat.Struct.Mol.Biol., 29, 2022
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7SMR
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![BU of 7smr by Molmil](/molmil-images/mine/7smr) | Cryo-EM structure of Torpedo acetylcholine receptor in complex with carbachol, desensitized state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E. | Deposit date: | 2021-10-26 | Release date: | 2022-03-09 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat.Struct.Mol.Biol., 29, 2022
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7SMM
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![BU of 7smm by Molmil](/molmil-images/mine/7smm) | Cryo-EM structure of Torpedo acetylcholine receptor in apo form | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E. | Deposit date: | 2021-10-26 | Release date: | 2022-03-09 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat.Struct.Mol.Biol., 29, 2022
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7SMQ
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![BU of 7smq by Molmil](/molmil-images/mine/7smq) | Cryo-EM structure of Torpedo acetylcholine receptor in apo form with added cholesterol | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E. | Deposit date: | 2021-10-26 | Release date: | 2022-03-09 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat.Struct.Mol.Biol., 29, 2022
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7T0Z
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![BU of 7t0z by Molmil](/molmil-images/mine/7t0z) | Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab175 IgG1 heavy chain, ... | Authors: | Noviello, C.M, Hibbs, R.E, Kreye, J, Teng, J, Pruss, H. | Deposit date: | 2021-11-30 | Release date: | 2022-07-13 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mechanisms of GABA A receptor autoimmune encephalitis. Cell, 185, 2022
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6CNK
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![BU of 6cnk by Molmil](/molmil-images/mine/6cnk) | Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Walsh Jr, R.M, Roh, S.H, Gharpure, A, Morales-Perez, C.L, Hibbs, R.E. | Deposit date: | 2018-03-08 | Release date: | 2018-05-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor. Nature, 557, 2018
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6CNJ
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![BU of 6cnj by Molmil](/molmil-images/mine/6cnj) | Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Walsh Jr, R.M, Roh, S.H, Gharpure, A, Morales-Perez, C.L, Teng, J, Hibbs, R.E. | Deposit date: | 2018-03-08 | Release date: | 2018-05-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor. Nature, 557, 2018
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6D6U
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![BU of 6d6u by Molmil](/molmil-images/mine/6d6u) | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | Deposit date: | 2018-04-22 | Release date: | 2018-06-27 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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6D6T
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![BU of 6d6t by Molmil](/molmil-images/mine/6d6t) | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | Deposit date: | 2018-04-22 | Release date: | 2018-06-27 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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2WN9
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![BU of 2wn9 by Molmil](/molmil-images/mine/2wn9) | Crystal structure of Aplysia ACHBP in complex with 4-0H-DMXBA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(E)-5,6-DIHYDRO-2,3'-BIPYRIDIN-3(4H)-YLIDENEMETHYL]-3-METHOXYPHENOL, SOLUBLE ACETYLCHOLINE RECEPTOR, ... | Authors: | Sulzenbacher, G, Hibbs, R, Shi, J, Talley, T, Conrod, S, Kem, W, Taylor, P, Marchot, P, Bourne, Y. | Deposit date: | 2009-07-07 | Release date: | 2009-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. Embo J., 28, 2009
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2WNL
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![BU of 2wnl by Molmil](/molmil-images/mine/2wnl) | CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH ANABASEINE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4,5,6-tetrahydro-2,3'-bipyridine, 5-amino-1-pyridin-3-ylpentan-1-one, ... | Authors: | Sulzenbacher, G, Hibbs, R, Shi, J, Talley, T, Conrod, S, Kem, W, Taylor, P, Marchot, P, Bourne, Y. | Deposit date: | 2009-07-09 | Release date: | 2009-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. EMBO J., 28, 2009
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2WNC
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![BU of 2wnc by Molmil](/molmil-images/mine/2wnc) | Crystal structure of Aplysia ACHBP in complex with tropisetron | Descriptor: | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE, Soluble acetylcholine receptor | Authors: | Sulzenbacher, G, Hibbs, R, Shi, J, Talley, T, Conrod, S, Kem, W, Taylor, P, Marchot, P, Bourne, Y. | Deposit date: | 2009-07-08 | Release date: | 2009-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. EMBO J., 28, 2009
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2WNJ
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![BU of 2wnj by Molmil](/molmil-images/mine/2wnj) | CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH DMXBA | Descriptor: | (3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3'-BIPYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, SOLUBLE ACETYLCHOLINE RECEPTOR, ... | Authors: | Sulzenbacher, G, Hibbs, R, Shi, J, Talley, T, Conrod, S, Kem, W, Taylor, P, Marchot, P, Bourne, Y. | Deposit date: | 2009-07-09 | Release date: | 2009-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Determinants for Interaction of Partial Agonists with Acetylcholine Binding Protein and Neuronal Alpha7 Nicotinic Acetylcholine Receptor. Embo J., 28, 2009
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