6CNK

Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor

Summary for 6CNK

• Entry DOI: 10.2210/pdb6cnk/pdb
• Related: 6CNJ
• EMDB information: 7535 7536
• Descriptor: Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, IgG1 Kappa Light Chain, ... (9 entities in total)
• Functional Keywords: ligand-gated ion channel, acetylcholine receptor, cys-loop receptor, membrane protein, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 390447.01

Authors

Walsh Jr, R.M.,Roh, S.H.,Gharpure, A.,Morales-Perez, C.L.,Hibbs, R.E. (deposition date: 2018-03-08, release date: 2018-05-02, Last modification date: 2020-07-29)

• Primary citation: Walsh, R.M.,Roh, S.H.,Gharpure, A.,Morales-Perez, C.L.,Teng, J.,Hibbs, R.E.; Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor.; Nature, 557:261-265, 2018; PubMed: 29720657; DOI: 10.1038/s41586-018-0081-7

Experimental method

ELECTRON MICROSCOPY (3.7 Å)