6CNK
Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D (A, B, D) | Neuronal acetylcholine receptor subunit alpha-4 | polymer | 386 | 44862.4 | 3 | UniProt (P43681) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 2 | C, E (C, E) | Neuronal acetylcholine receptor subunit beta-2 | polymer | 403 | 46748.9 | 2 | UniProt (P17787) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 3 | F, H (F, J) | IgG1 Kappa Light Chain | polymer | 238 | 26378.6 | 2 | Mus musculus (house mouse) | ||
| 4 | G, I (G, K) | IgG1 Heavy Chain | polymer | 462 | 51195.7 | 2 | Mus musculus (house mouse) | ||
| 5 | J, K (H, I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 6 | L, Q, X (A, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | AA, BA, M, N, S... (E, A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 10 | Chemie (Y01) | |||
| 8 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | P, R, W (A, B, D) | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 3 | Chemie (NCT) |
Sequence modifications
A, B, D: 1 - 338 (UniProt: P43681)
A, B, D: 345 - 386 (UniProt: P43681)
C, E: 1 - 328 (UniProt: P17787)
C, E: 337 - 393 (UniProt: P17787)
A, B, D: 345 - 386 (UniProt: P43681)
| PDB | External Database | Details |
|---|---|---|
| Asp 339 | - | linker |
| Thr 340 | - | linker |
| Asp 341 | - | linker |
| Phe 342 | - | linker |
| Glu 343 | - | linker |
| Arg 344 | - | linker |
C, E: 337 - 393 (UniProt: P17787)
| PDB | External Database | Details |
|---|---|---|
| His 329 | - | linker |
| His 330 | - | linker |
| Asp 331 | - | linker |
| Asp 332 | - | linker |
| Asp 333 | - | linker |
| Gln 334 | - | linker |
| Glu 335 | - | linker |
| Arg 336 | - | linker |
| Ser 394 | - | expression tag |
| Ala 395 | - | expression tag |
| Trp 396 | - | expression tag |
| Ser 397 | - | expression tag |
| His 398 | - | expression tag |
| Pro 399 | - | expression tag |
| Gln 400 | - | expression tag |
| Phe 401 | - | expression tag |
| Glu 402 | - | expression tag |
| Lys 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 383233.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 6040.6 | |
| All* | Total formula weight | 390447.0 |
