6CNK
Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D (A, B, D) | Neuronal acetylcholine receptor subunit alpha-4 | polymer | 386 | 44862.4 | 3 | UniProt (P43681) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 2 | C, E (C, E) | Neuronal acetylcholine receptor subunit beta-2 | polymer | 403 | 46748.9 | 2 | UniProt (P17787) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 3 | F, H (F, J) | IgG1 Kappa Light Chain | polymer | 238 | 26378.6 | 2 | Mus musculus (house mouse) | ||
| 4 | G, I (G, K) | IgG1 Heavy Chain | polymer | 462 | 51195.7 | 2 | Mus musculus (house mouse) | ||
| 5 | J, K (H, I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 6 | L, Q, X (A, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | AA, BA, M, N, S... (E, A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 10 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 8 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 9 | P, R, W (A, B, D) | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 3 | Chemie (NCT) PubChem (942) PubChem (89594) PubChem (157672) |
Sequence modifications
A, B, D: 1 - 338 (UniProt: P43681)
A, B, D: 345 - 386 (UniProt: P43681)
C, E: 1 - 328 (UniProt: P17787)
C, E: 337 - 393 (UniProt: P17787)
A, B, D: 345 - 386 (UniProt: P43681)
| PDB | External Database | Details |
|---|---|---|
| Asp 339 | - | linker |
| Thr 340 | - | linker |
| Asp 341 | - | linker |
| Phe 342 | - | linker |
| Glu 343 | - | linker |
| Arg 344 | - | linker |
C, E: 337 - 393 (UniProt: P17787)
| PDB | External Database | Details |
|---|---|---|
| His 329 | - | linker |
| His 330 | - | linker |
| Asp 331 | - | linker |
| Asp 332 | - | linker |
| Asp 333 | - | linker |
| Gln 334 | - | linker |
| Glu 335 | - | linker |
| Arg 336 | - | linker |
| Ser 394 | - | expression tag |
| Ala 395 | - | expression tag |
| Trp 396 | - | expression tag |
| Ser 397 | - | expression tag |
| His 398 | - | expression tag |
| Pro 399 | - | expression tag |
| Gln 400 | - | expression tag |
| Phe 401 | - | expression tag |
| Glu 402 | - | expression tag |
| Lys 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 383233.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 6040.6 | |
| All* | Total formula weight | 390447.0 |
