7SMS

Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine

Summary for 7SMS

• Entry DOI: 10.2210/pdb7sms/pdb
• EMDB information: 25202 25205 25206 25207 25208
• Descriptor: Acetylcholine receptor subunit alpha, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Acetylcholine receptor subunit delta, ... (10 entities in total)
• Functional Keywords: acetylcholine receptor, nicotinic receptor, torpedo, cys-loop receptor, ion channel, muscle-type nicotinic receptor, transport protein
• Biological source: Tetronarce californica (Pacific electric ray); More
• Total number of polymer chains: 5
• Total formula weight: 279176.21

Authors

Rahman, M.M.,Basta, T.,Teng, J.,Lee, M.,Worrell, B.T.,Stowell, M.H.B.,Hibbs, R.E. (deposition date: 2021-10-26, release date: 2022-03-09, Last modification date: 2022-04-27)

• Primary citation: Rahman, M.M.,Basta, T.,Teng, J.,Lee, M.,Worrell, B.T.,Stowell, M.H.B.,Hibbs, R.E.; Structural mechanism of muscle nicotinic receptor desensitization and block by curare.; Nat.Struct.Mol.Biol., 29:386-394, 2022; PubMed: 35301478; DOI: 10.1038/s41594-022-00737-3

Experimental method

ELECTRON MICROSCOPY (3.18 Å)