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PDB: 144 件

3B1T
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Crystal structure of human peptidylarginine deiminase 4 in complex with o-Cl-amidine
分子名称: 2-{[(2S)-1-amino-5-{[(1Z)-2-chloroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, CALCIUM ION, Protein-arginine deiminase type-4, ...
著者Causey, C.P, Jones, J.E, Slack, J.L, Kamei, D, Jones Jr, L.E, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, A.A, Luo, Y, Hashimoto, H, Shimizu, T, Sato, M, Hofseth, L.J, Thompson, P.R.
登録日2011-07-13
公開日2011-10-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors
J.Med.Chem., 54, 2011
5H6K
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DNA targeting ADP-ribosyltransferase Pierisin-1
分子名称: 1,2-ETHANEDIOL, Pierisin-1
著者Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
登録日2016-11-14
公開日2017-08-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
5H6N
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DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form
分子名称: Pierisin-1
著者Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
登録日2016-11-14
公開日2017-08-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
5H6L
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DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+
分子名称: 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1
著者Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
登録日2016-11-14
公開日2017-08-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
5H6M
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DNA targeting ADP-ribosyltransferase Pierisin-1
分子名称: 1,2-ETHANEDIOL, Pierisin-1
著者Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
登録日2016-11-14
公開日2017-08-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
7FI3
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Archaeal oligopeptide permease A (OppA) from Thermococcus kodakaraensis in complex with an endogenous pentapeptide
分子名称: ABC-type dipeptide/oligopeptide transport system, GLYCEROL, HEXAETHYLENE GLYCOL, ...
著者Yokoyama, H, Kamei, N, Konishi, K, Hara, K, Hashimoto, H.
登録日2021-07-30
公開日2022-04-13
最終更新日2022-06-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for peptide recognition by archaeal oligopeptide permease A.
Proteins, 90, 2022
5H6J
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DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1
著者Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
登録日2016-11-14
公開日2017-08-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
8FJM
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Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - P212121 space group
分子名称: ACETATE ION, CALCIUM ION, Histone-lysine N-methyltransferase, ...
著者Frisbie, V.S, Hashimoto, H, Debler, E.W.
登録日2022-12-20
公開日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and Mechanism of the atypical Trypanosoma brucei DOT1A histone H3K76 methyltransferase
To Be Published
8GNN
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Crystal structure of the human RAD9-RAD1-HUS1-RAD17 complex
分子名称: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Cell cycle checkpoint protein RAD17, ...
著者Hara, K, Nagata, K, Iida, N, Hashimoto, H.
登録日2022-08-24
公開日2023-03-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.119 Å)
主引用文献The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.
J.Biol.Chem., 299, 2023
5FHI
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Crystallographic structure of PsoE without Co
分子名称: GLUTATHIONE, Glutathione S-transferase, putative
著者Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K.
登録日2015-12-22
公開日2016-04-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
5F8B
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Crystallographic Structure of PsoE with Co
分子名称: (5~{S},8~{S},9~{R})-2-[(~{E})-hex-1-enyl]-8-methoxy-3-methyl-9-oxidanyl-8-(phenylcarbonyl)-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, COBALT (II) ION, GLUTATHIONE, ...
著者Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K.
登録日2015-12-09
公開日2016-04-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
4XZF
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Crystal structure of HIRAN domain of human HLTF in complex with DNA
分子名称: (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor
著者Hishiki, A, Hashimoto, H.
登録日2015-02-04
公開日2015-04-15
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
5EYO
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BU of 5eyo by Molmil
The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA
分子名称: DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max
著者Wang, D, Hashimoto, H, Zhang, X, Cheng, X.
登録日2015-11-25
公開日2016-12-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.
Nucleic Acids Res., 45, 2017
1WN7
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BU of 1wn7 by Molmil
Crystal structure of archaeal family B DNA polymerase mutant
分子名称: Family B DNA Polymerase, GLYCEROL, NICKEL (II) ION
著者Kuroita, T, Matsumura, H, Yokota, N, Hashimoto, H, Imanaka, T, Inoue, T, Kai, Y.
登録日2004-07-28
公開日2005-08-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural Mechanism for Coordination of Proofreading and Polymerase Activities in Archaeal DNA Polymerases
J.Mol.Biol., 351, 2005
5XPT
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BU of 5xpt by Molmil
Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a tetragonal crystal
分子名称: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
著者Hara, K, Taharazako, S, Hashimoto, H.
登録日2017-06-05
公開日2017-09-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
J. Biol. Chem., 292, 2017
5XPU
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Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal
分子名称: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
著者Hara, K, Taharazako, S, Hashimoto, H.
登録日2017-06-05
公開日2017-09-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.304 Å)
主引用文献Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
J. Biol. Chem., 292, 2017
7CP7
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Crystal structure of FqzB, native proteins
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, IODIDE ION, MAK1-like monooxygenase
著者Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K.
登録日2020-08-06
公開日2020-12-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.
Biochemistry, 59, 2020
8FJN
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Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - C2221 space group
分子名称: CALCIUM ION, CHLORIDE ION, Histone-lysine N-methyltransferase, ...
著者Frisbie, V.S, Hashimoto, H, Debler, E.W.
登録日2022-12-20
公開日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and Mechanism of the atypical Trypanosoma brucei DOT1A histone H3K76 methyltransferase
To Be Published
7CP6
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Crystal structure of FqzB
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, IODIDE ION, MAK1-like monooxygenase, ...
著者Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K.
登録日2020-08-06
公開日2020-12-30
最終更新日2021-01-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.
Biochemistry, 59, 2020
6J8Y
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Crystal structure of the human RAD9-HUS1-RAD1-RHINO complex
分子名称: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1, ...
著者Hara, K, Iida, N, Sakurai, H, Hashimoto, H.
登録日2019-01-21
公開日2019-12-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.
J.Biol.Chem., 295, 2020
6MR4
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BU of 6mr4 by Molmil
Crystal structure of the Sth1 bromodomain from S.cerevisiae
分子名称: Nuclear protein STH1/NPS1
著者Seo, H.S, Hashimoto, H, Krolak, A, Debler, E.W, Blus, B.J.
登録日2018-10-11
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Substrate Affinity and Specificity of the ScSth1p Bromodomain Are Fine-Tuned for Versatile Histone Recognition.
Structure, 27, 2019
1UHN
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The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana
分子名称: CALCIUM ION, calcineurin B-like protein 2
著者Nagae, M, Nozawa, A, Koizumi, N, Sano, H, Hashimoto, H, Sato, M, Shimizu, T.
登録日2003-07-07
公開日2003-11-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Crystal Structure of the Novel Calcium-binding Protein AtCBL2 from Arabidopsis thaliana
J.Biol.Chem., 278, 2003
1WDA
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Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with benzoyl-L-arginine amide
分子名称: CALCIUM ION, N-[(E)-2-AMINO-1-(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)-2-HYDROXYVINYL]BENZAMIDE, Protein-arginine deiminase type IV, ...
著者Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M.
登録日2004-05-12
公開日2004-07-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for Ca(2+)-induced activation of human PAD4
Nat.Struct.Mol.Biol., 11, 2004
1WD9
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Calcium bound form of human peptidylarginine deiminase type4 (PAD4)
分子名称: CALCIUM ION, Protein-arginine deiminase type IV, SULFATE ION
著者Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M.
登録日2004-05-12
公開日2004-07-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for Ca(2+)-induced activation of human PAD4
Nat.Struct.Mol.Biol., 11, 2004
7YBD
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Crystal structure of sliding DNA clamp of Clostridioides difficile
分子名称: Beta sliding clamp, TRIETHYLENE GLYCOL
著者Hishiki, A, Okazaki, S, Hara, K, Hashimoto, H.
登録日2022-06-29
公開日2022-10-19
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile.
J.Biochem., 173, 2022

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