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PDB: 133 件
6ZK7
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Crystal Structure of human PYROXD1/FAD complex
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
著者Meinhart, A, Asanovic, I, Martinez, J, Clausen, T.
登録日2020-06-30
公開日2021-05-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Mol.Cell, 81, 2021
1H3A
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BU of 1h3a by Molmil
Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme
分子名称: (2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, SQUALENE--HOPENE CYCLASE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3C
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Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE, SQUALENE--HOPENE CYCLASE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-08-25
公開日2003-08-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1GSZ
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Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, SQUALENE--HOPENE CYCLASE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE
著者Lenhart, A, Weihofen, W.A, Pleschke, A.E.W, Schulz, G.E.
登録日2002-01-09
公開日2003-01-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Chem.Biol., 9, 2002
1H35
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Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme
分子名称: (4'-{[ALLYL(METHYL)AMINO]METHYL}-1,1'-BIPHENYL-4-YL)(4-BROMOPHENYL)METHANONE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, SQUALENE--HOPENE CYCLASE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H37
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Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, SQUALENE--HOPENE CYCLASE, {4-[((1S,2S)-2-{[ALLYL(CYCLOPROPYL)AMINO]METHYL}CYCLOPROPYL)METHOXY]PHENYL}(4-BROMOPHENYL)METHANONE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
7AA4
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Structure of ClpC1-NTD bound to a CymA analogue
分子名称: Negative regulator of genetic competence ClpC/mecB, polymer Cyclomarin A analogue
著者Meinhart, A, Morreale, F.E, Kaiser, M, Clausen, T.
登録日2020-09-03
公開日2021-08-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献BacPROTACs mediate targeted protein degradation in bacteria.
Cell, 185, 2022
6QDL
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Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
分子名称: UNC-45
著者Meinhart, A, Clausen, T, Hellerschmied, D.
登録日2019-01-02
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.929 Å)
主引用文献Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
Nat Commun, 10, 2019
6QDK
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Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
分子名称: UNC-45,UNC-45
著者Meinhart, A, Clausen, T, Hellerschmied, D.
登録日2019-01-02
公開日2019-10-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
Nat Commun, 10, 2019
8B9O
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Structure of the C-terminal domain of ClpC2 from Mycobacterium smegmatis
分子名称: Clp amino terminal domain protein, phospho-arginine
著者Meinhart, A, Hoi, D.M, Clausen, T.
登録日2022-10-06
公開日2023-07-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Cell, 186, 2023
8B9U
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BU of 8b9u by Molmil
Structure of ClpC1 NTD from Mycobacterium tuberculosis
分子名称: (MLE)V(MAA)(E9M)G, ATP-dependent Clp protease ATP-binding subunit ClpC1, FORMIC ACID
著者Meinhart, A, Hoi, D.M, Clausen, T.
登録日2022-10-10
公開日2023-07-05
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Cell, 186, 2023
6QDM
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BU of 6qdm by Molmil
Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
分子名称: UNC-45,UNC-45
著者Meinhart, A, Clausen, T, Hellerschmied, D.
登録日2019-01-02
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
Nat Commun, 10, 2019
6QDJ
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Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
分子名称: 1,4-BUTANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ADENOSINE-5'-DIPHOSPHATE, ...
著者Meinhart, A, Clausen, T, Arnese, R.
登録日2019-01-02
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.884 Å)
主引用文献Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
Nat Commun, 10, 2019
1S4E
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BU of 1s4e by Molmil
Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium
分子名称: ADENOSINE-5'-DIPHOSPHATE, Galactokinase, MAGNESIUM ION, ...
著者Hartley, A, Glynn, S.E, Barynin, V, Baker, P.J, Sedelnikova, S.E, Verhees, C, de Geus, D, van der Oost, J, Timson, D.J, Reece, R.J, Rice, D.W.
登録日2004-01-16
公開日2004-04-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase
J.Mol.Biol., 337, 2004
1Q1H
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BU of 1q1h by Molmil
An extended winged helix domain in general transcription factor E/IIE alpha
分子名称: Transcription Factor E
著者Meinhart, A, Blobel, J, Cramer, P.
登録日2003-07-21
公開日2003-12-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献An Extended Winged Helix Domain in General Transcription Factor E/IIE alpha
J.Biol.Chem., 278, 2003
1SZA
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BU of 1sza by Molmil
The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model
分子名称: CTD-peptide, PCF11 protein
著者Meinhart, A, Cramer, P.
登録日2004-04-05
公開日2004-07-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors.
Nature, 430, 2004
2RMN
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BU of 2rmn by Molmil
The solution structure of the p63 DNA-binding domain
分子名称: Tumor protein 63, ZINC ION
著者Enthart, A, Kessler, H.
登録日2007-11-01
公開日2008-11-11
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure and binding specificity of the p63 DNA binding domain
Sci Rep, 6, 2016
5BTT
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BU of 5btt by Molmil
Switching GFP fluorescence using genetically encoded phenyl azide chemistry through two different non-native post-translational modifications routes at the same position.
分子名称: GLYCEROL, Green fluorescent protein, SULFATE ION
著者Hartley, A.M, Worthy, H.L, Reddington, S.C, Rizkallah, P.J, Jones, D.D.
登録日2015-06-03
公開日2016-07-13
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle.
Chem Sci, 7, 2016
1SZ9
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BU of 1sz9 by Molmil
The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model
分子名称: PCF11 protein
著者Meinhart, A, Cramer, P.
登録日2004-04-05
公開日2004-07-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors.
Nature, 430, 2004
5BT0
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Switching GFP fluorescence using genetically encoded phenyl azide chemistry through two different non-native post-translational modifications routes at the same position.
分子名称: Green fluorescent protein, SULFATE ION
著者Hartley, A.M, Worthy, H.L, Reddington, S.C, Rizkallah, P.J, Jones, D.D.
登録日2015-06-02
公開日2016-07-13
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle.
Chem Sci, 7, 2016
6HU9
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III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, CALCIUM ION, ...
著者Hartley, A.M, Pinotsis, N, Marechal, A.
登録日2018-10-05
公開日2018-12-26
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1.
Nat. Struct. Mol. Biol., 26, 2019
1GVN
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BU of 1gvn by Molmil
Crystal Structure of the Plasmid Maintenance System epsilon/zeta: Meachnism of toxin inactivation and toxin function
分子名称: EPSILON, SULFATE ION, ZETA
著者Meinhart, A, Alonso, J.C, Straeter, N, Saenger, W.
登録日2002-02-19
公開日2003-01-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of the Plasmid Maintenance System Epsilon /Zeta : Functional Mechanism of Toxin Zeta and Inactivation by Epsilon 2 Zeta 2 Complex Formation
Proc.Natl.Acad.Sci.USA, 100, 2003
1O6Q
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Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{4-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-BUT-2-ENYL}-METHYL-AMINE, SQUALENE--HOPENE CYCLASE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-10-13
公開日2003-10-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6R
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BU of 1o6r by Molmil
Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-HEXYL-}-METHYL-AMIN, SQUALENE--HOPENE CYCLASE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-10-13
公開日2003-10-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6H
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Squalene-Hopene Cyclase
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE, SQUALENE--HOPENE CYCLASE
著者Lenhart, A, Reinert, D.J, Weihofen, W.A, Aebi, J.D, Dehmlow, H, Morand, O.H, Schulz, G.E.
登録日2002-10-03
公開日2003-10-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003

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