1O6H

Squalene-Hopene Cyclase

Summary for 1O6H

Entry DOI	10.2210/pdb1o6h/pdb
Related	1GSZ 1H35 1H36 1H37 1H39 1H3A 1H3B 1H3C 1O6Q 1O6R 1O79 1SQC 1UMP 2SQC 3SQC
Descriptor	SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE, ... (4 entities in total)
Functional Keywords	isomerase, cholesterol biosynthesis, inhibitor, oxidosqualene cyclase, monotopic membrane protein
Biological source	ALICYCLOBACILLUS ACIDOCALDARIUS
Total number of polymer chains	3
Total formula weight	217229.68
Authors	Lenhart, A.,Reinert, D.J.,Weihofen, W.A.,Aebi, J.D.,Dehmlow, H.,Morand, O.H.,Schulz, G.E. (deposition date: 2002-10-03, release date: 2003-10-02, Last modification date: 2018-06-20)
Primary citation	Lenhart, A.,Reinert, D.J.,Aebi, J.D.,Dehmlow, H.,Morand, O.H.,Schulz, G.E. Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase J.Med.Chem., 46:2083-, 2003 Cited by PubMed: 12747780 DOI: 10.1021/JM0211218 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation