1GSZ

Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071

Summary for 1GSZ

Entry DOI	10.2210/pdb1gsz/pdb
Related	1SQC 2SQC 3SQC
Descriptor	SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, ... (4 entities in total)
Functional Keywords	isomerase, cholesterol biosynthesis, inhibitor oxidosqualene cyclase, monotopic membrane protein
Biological source	ALICYCLOBACILLUS ACIDOCALDARIUS
Total number of polymer chains	3
Total formula weight	217214.54
Authors	Lenhart, A.,Weihofen, W.A.,Pleschke, A.E.W.,Schulz, G.E. (deposition date: 2002-01-09, release date: 2003-01-16, Last modification date: 2019-05-08)
Primary citation	Lenhart, A.,Weihofen, W.A.,Pleschke, A.E.W.,Schulz, G.E. Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071 Chem.Biol., 9:639-, 2002 Cited by PubMed: 12031670 DOI: 10.1016/S1074-5521(02)00138-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation