2EGH
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![BU of 2egh by Molmil](/molmil-images/mine/2egh) | Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with a magnesium ion, NADPH and fosmidomycin | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MAGNESIUM ION, ... | Authors: | Yajima, S, Hara, K, Iino, D, Sasaki, Y, Kuzuyama, T, Seto, H. | Deposit date: | 2007-03-01 | Release date: | 2007-06-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin Acta Crystallogr.,Sect.F, 63, 2007
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4XZG
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![BU of 4xzg by Molmil](/molmil-images/mine/4xzg) | Crystal structure of HIRAN domain of human HLTF | Descriptor: | Helicase-like transcription factor | Authors: | Ikegaya, Y, Hara, K, Hashimoto, H. | Deposit date: | 2015-02-04 | Release date: | 2015-04-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance J.Biol.Chem., 290, 2015
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1WDW
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![BU of 1wdw by Molmil](/molmil-images/mine/1wdw) | Structural basis of mutual activation of the tryptophan synthase a2b2 complex from a hyperthermophile, Pyrococcus furiosus | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Tryptophan synthase alpha chain, Tryptophan synthase beta chain 1 | Authors: | Lee, S.J, Ogasahara, K, Ma, J, Nishio, K, Ishida, M, Yamagata, Y, Tsukihara, T, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-05-19 | Release date: | 2005-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Conformational Changes in the Tryptophan Synthase from a Hyperthermophile upon alpha(2)beta(2) Complex Formation: Crystal Structure of the Complex Biochemistry, 44, 2005
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3W08
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![BU of 3w08 by Molmil](/molmil-images/mine/3w08) | Crystal structure of aldoxime dehydratase | Descriptor: | Aldoxime dehydratase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Hashimoto, H, Nomura, J, Hashimoto, Y, Oinuma, K.I, Wada, K, Hishiki, A, Hara, K, Kobayashi, M. | Deposit date: | 2012-10-24 | Release date: | 2013-02-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis. Proc.Natl.Acad.Sci.USA, 110, 2013
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3ALR
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![BU of 3alr by Molmil](/molmil-images/mine/3alr) | Crystal structure of Nanos | Descriptor: | Nanos protein, ZINC ION | Authors: | Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M. | Deposit date: | 2010-08-06 | Release date: | 2011-02-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of zinc-finger domain of Nanos and its functional implications Embo Rep., 11, 2010
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7D8E
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![BU of 7d8e by Molmil](/molmil-images/mine/7d8e) | Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-09 | Descriptor: | 1,2-ETHANEDIOL, Glutaminyl-peptide cyclotransferase, SULFATE ION, ... | Authors: | Dileep, K.V, Ihara, K, Sakai, N, Shirozu, M, Zhang, K.Y.J. | Deposit date: | 2020-10-08 | Release date: | 2021-12-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-09 To Be Published
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3VXF
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![BU of 3vxf by Molmil](/molmil-images/mine/3vxf) | X/N Joint refinement of Human alpha-thrombin-Bivalirudin complex PD5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BIVALIRUDIN, Thrombin heavy chain, ... | Authors: | Yamada, T, Kurihara, K, Masumi, K, Tamada, T, Tomoyori, K, Ohnishi, Y, Tanaka, I, Kuroki, R, Niimura, N. | Deposit date: | 2012-09-12 | Release date: | 2013-09-04 | Last modified: | 2020-07-29 | Method: | NEUTRON DIFFRACTION (1.602 Å), X-RAY DIFFRACTION | Cite: | Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex Biochim.Biophys.Acta, 1834, 2013
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6LZJ
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![BU of 6lzj by Molmil](/molmil-images/mine/6lzj) | Aquifex aeolicus MutL ATPase domain complexed with AMPPCP | Descriptor: | DNA mismatch repair protein MutL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Fukui, K, Izuhara, K, Yano, T. | Deposit date: | 2020-02-19 | Release date: | 2020-07-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.72835565 Å) | Cite: | A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL. J.Biol.Chem., 295, 2020
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1VFF
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4FW9
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![BU of 4fw9 by Molmil](/molmil-images/mine/4fw9) | Crystal structure of the Lon-like protease MtaLonC | Descriptor: | PHOSPHATE ION, TTC1975 peptidase | Authors: | Chang, C.I, Ihara, K, Kuo, C.I, Huang, K.F, Wakatsuki, S. | Deposit date: | 2012-06-30 | Release date: | 2013-06-26 | Last modified: | 2013-09-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors Acta Crystallogr.,Sect.D, 69, 2013
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2TSA
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![BU of 2tsa by Molmil](/molmil-images/mine/2tsa) | AZURIN MUTANT M121A | Descriptor: | AZURIN, COPPER (II) ION | Authors: | Tsai, L.-C, Bonander, N, Harata, K, Karlsson, B.G, Vanngard, T, Langer, V, Sjolin, L. | Deposit date: | 1996-05-10 | Release date: | 1996-11-08 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mutant Met121Ala of Pseudomonas aeruginosa azurin and its azide derivative: crystal structures and spectral properties. Acta Crystallogr.,Sect.D, 52, 1996
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2TSB
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![BU of 2tsb by Molmil](/molmil-images/mine/2tsb) | AZURIN MUTANT M121A-AZIDE | Descriptor: | AZIDE ION, AZURIN AZIDE, COPPER (II) ION | Authors: | Tsai, L.-C, Bonander, N, Harata, K, Karlsson, B.G, Vanngard, T, Langer, V, Sjolin, L. | Deposit date: | 1996-05-10 | Release date: | 1996-11-08 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mutant Met121Ala of Pseudomonas aeruginosa azurin and its azide derivative: crystal structures and spectral properties. Acta Crystallogr.,Sect.D, 52, 1996
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8I5W
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![BU of 8i5w by Molmil](/molmil-images/mine/8i5w) | Crystal structure of the DHR-2 domain of DOCK10 in complex with Rac1 | Descriptor: | Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 1, SULFATE ION | Authors: | Kukimoto-Niino, M, Mishima-Tsumagari, C, Ihara, K, Fukui, Y, Yokoyama, S, Shirouzu, M. | Deposit date: | 2023-01-26 | Release date: | 2023-03-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.432 Å) | Cite: | Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Biochem.Biophys.Res.Commun., 653, 2023
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8I5V
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![BU of 8i5v by Molmil](/molmil-images/mine/8i5v) | DOCK10 mutant L1903Y complexed with Rac1 | Descriptor: | Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 1, SULFATE ION | Authors: | Kukimoto-Niino, M, Mishima-Tsumagari, C, Ihara, K, Fukui, Y, Yokoyama, S, Shirouzu, M. | Deposit date: | 2023-01-26 | Release date: | 2023-03-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.726 Å) | Cite: | Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Biochem.Biophys.Res.Commun., 653, 2023
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4GPG
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![BU of 4gpg by Molmil](/molmil-images/mine/4gpg) | X/N joint refinement of Achromobacter Lyticus Protease I free form at pD8.0 | Descriptor: | Protease 1 | Authors: | Ohnishi, Y, Yamada, T, Kurihara, K, Tanaka, I, Sakiyama, F, Masaki, T, Niimura, N. | Deposit date: | 2012-08-21 | Release date: | 2013-09-11 | Last modified: | 2023-11-08 | Method: | NEUTRON DIFFRACTION (1.895 Å), X-RAY DIFFRACTION | Cite: | Neutron and X-ray crystallographic analysis of Achromobacter protease I at pD 8.0: protonation states and hydration structure in the free-form. Biochim.Biophys.Acta, 1834, 2013
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8HEW
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![BU of 8hew by Molmil](/molmil-images/mine/8hew) | Potato 14-3-3 St14f | Descriptor: | 14-3-3 protein, StFDL1 peptide | Authors: | Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C. | Deposit date: | 2022-11-08 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening. Plant J., 112, 2022
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4U4P
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![BU of 4u4p by Molmil](/molmil-images/mine/4u4p) | Crystal structure of the human condensin SMC hinge domain heterodimer with short coiled coils | Descriptor: | Structural maintenance of chromosomes protein 2, Structural maintenance of chromosomes protein 4 | Authors: | Uchiyama, S, Kawahara, K, Hosokawa, Y, Fukakusa, S, Oki, H, Nakamura, S, Noda, M, Takino, R, Miyahara, Y, Maruno, T, Kobayashi, Y, Ohkubo, T, Fukui, K. | Deposit date: | 2014-07-24 | Release date: | 2015-08-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural basis for dimer information and DNA recognition of human SMC proteins to be published
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7EHZ
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![BU of 7ehz by Molmil](/molmil-images/mine/7ehz) | Structure of human NNMT in complex with macrocyclic peptide 2 | Descriptor: | Nicotinamide N-methyltransferase, macrocyclic peptide 2 | Authors: | Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M. | Deposit date: | 2021-03-30 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. Acs Med.Chem.Lett., 12, 2021
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7EGU
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![BU of 7egu by Molmil](/molmil-images/mine/7egu) | Structure of human NNMT in complex with macrocyclic peptide X | Descriptor: | Nicotinamide N-methyltransferase, macrocyclic peptide X | Authors: | Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M. | Deposit date: | 2021-03-26 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. Acs Med.Chem.Lett., 12, 2021
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7EI2
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![BU of 7ei2 by Molmil](/molmil-images/mine/7ei2) | Structure of human NNMT in complex with macrocyclic peptide 8 | Descriptor: | Nicotinamide N-methyltransferase, macrocyclic peptide 8 | Authors: | Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M. | Deposit date: | 2021-03-30 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. Acs Med.Chem.Lett., 12, 2021
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8YTE
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![BU of 8yte by Molmil](/molmil-images/mine/8yte) | Crystal Structure of TrkA D5 domain in complex with macrocyclic peptide | Descriptor: | 1,2-ETHANEDIOL, AMINOMETHYLAMIDE, High affinity nerve growth factor receptor, ... | Authors: | Yamada, T, Mihara, K, Ueda, T, Yamauchi, D, Shimizu, M, Ando, A, Mayumi, K, Nakata, Z, Mikamiyama, H. | Deposit date: | 2024-03-25 | Release date: | 2024-07-10 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists. J.Med.Chem., 2024
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8YTD
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![BU of 8ytd by Molmil](/molmil-images/mine/8ytd) | Crystal Structure of TrkA D5 domain in complex with two different macrocyclic peptides | Descriptor: | 1,2-ETHANEDIOL, High affinity nerve growth factor receptor, Macrocyclic Peptide | Authors: | Yamada, T, Mihara, K, Ueda, T, Yamauchi, D, Shimizu, M, Ando, A, Mayumi, K, Nakata, Z, Mikamiyama, H. | Deposit date: | 2024-03-25 | Release date: | 2024-07-10 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists. J.Med.Chem., 2024
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8IHL
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![BU of 8ihl by Molmil](/molmil-images/mine/8ihl) | Overlapping tri-nucleosome | Descriptor: | DNA (353-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Nishimura, M, Fujii, T, Tanaka, H, Maehara, K, Nozawa, K, Takizawa, Y, Ohkawa, Y, Kurumizaka, H. | Deposit date: | 2023-02-23 | Release date: | 2024-01-17 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (7.64 Å) | Cite: | Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties. Commun Biol, 7, 2024
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8IVG
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![BU of 8ivg by Molmil](/molmil-images/mine/8ivg) | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease | Descriptor: | (3S)-3-(4-methylphenyl)-3-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoylamino]propanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Kelch-like ECH-associated protein 1, ... | Authors: | Otake, K, Ubukata, M, Nagahashi, N, Ogawa, N, Hantani, Y, Hantani, R, Adachi, T, Nomura, A, Yamaguchi, K, Maekawa, M, Mamada, H, Motomura, T, Sato, M, Harada, K. | Deposit date: | 2023-03-27 | Release date: | 2023-06-14 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor. Acs Med.Chem.Lett., 14, 2023
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6LZI
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![BU of 6lzi by Molmil](/molmil-images/mine/6lzi) | Aquifex aeolicus MutL ATPase domain complexed with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL, ... | Authors: | Fukui, K, Izuhara, K, Yano, T. | Deposit date: | 2020-02-19 | Release date: | 2020-07-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.69105685 Å) | Cite: | A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL. J.Biol.Chem., 295, 2020
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