8I5W

Crystal structure of the DHR-2 domain of DOCK10 in complex with Rac1

Summary for 8I5W

• Entry DOI: 10.2210/pdb8i5w/pdb
• Related: 8I5F 8I5V
• Descriptor: Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 1, SULFATE ION, ... (4 entities in total)
• Functional Keywords: dock, gef, dhr-2, gtpase, rho, rac, cdc42, signaling protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 52930.22

Authors

Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Ihara, K.,Fukui, Y.,Yokoyama, S.,Shirouzu, M. (deposition date: 2023-01-26, release date: 2023-03-15)

• Primary citation: Kukimoto-Niino, M.,Ihara, K.,Mishima-Tsumagari, C.,Inoue, M.,Fukui, Y.,Yokoyama, S.,Shirouzu, M.; Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.; Biochem.Biophys.Res.Commun., 653:12-20, 2023; PubMed: 36848820; DOI: 10.1016/j.bbrc.2023.02.054

Experimental method

X-RAY DIFFRACTION (2.432 Å)