8YTD
Crystal Structure of TrkA D5 domain in complex with two different macrocyclic peptides
Summary for 8YTD
Entry DOI | 10.2210/pdb8ytd/pdb |
Descriptor | High affinity nerve growth factor receptor, Macrocyclic Peptide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 15378.30 |
Authors | Yamada, T.,Mihara, K.,Ueda, T.,Yamauchi, D.,Shimizu, M.,Ando, A.,Mayumi, K.,Nakata, Z.,Mikamiyama, H. (deposition date: 2024-03-25, release date: 2024-07-10, Last modification date: 2024-07-24) |
Primary citation | Yamada, T.,Mihara, K.,Ueda, T.,Yamauchi, D.,Shimizu, M.,Ando, A.,Mayumi, K.,Nakata, Z.,Mikamiyama, H. Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists. J.Med.Chem., 67:11197-11208, 2024 Cited by PubMed: 38950284DOI: 10.1021/acs.jmedchem.4c00715 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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