3VXF

X/N Joint refinement of Human alpha-thrombin-Bivalirudin complex PD5

Summary for 3VXF
Related3VXE
Related PRD IDPRD_001145 PRD_001148
DescriptorThrombin light chain, Thrombin heavy chain, BIVALIRUDIN, ... (6 entities in total)
Functional Keywordsserine protease, hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains4
Total formula weight36297.27
Authors
Yamada, T.,Kurihara, K.,Masumi, K.,Tamada, T.,Tomoyori, K.,Ohnishi, Y.,Tanaka, I.,Kuroki, R.,Niimura, N. (deposition date: 2012-09-12, release date: 2013-09-04, Last modification date: 2020-07-29)
Primary citationKurihara, K.,Kuroki, R.,Masumi, K.,Niimura, N.,Ohnishi, Y.,Tamada, T.,Tanaka, I.,Tomoyori, K.,Yamada, T.
Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex
Biochim.Biophys.Acta, 1834:1532-1538, 2013
PubMed: 23712263
DOI: 110.1016/j.bbapap.2013.05.014
PDB entries with the same primary citation
Experimental method
NEUTRON DIFFRACTION (2.752 Å)
X-RAY DIFFRACTION (1.602 Å)
Structure validation
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PDB entries from 2021-06-23