5LSQ
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![BU of 5lsq by Molmil](/molmil-images/mine/5lsq) | Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - I222 crystal form | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Ethylene Forming Enzyme, ... | Authors: | Zhang, Z, McDonough, M.A, Schofield, C.J. | Deposit date: | 2016-09-05 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3R03
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![BU of 3r03 by Molmil](/molmil-images/mine/3r03) | |
8J5X
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![BU of 8j5x by Molmil](/molmil-images/mine/8j5x) | The crystal structure of TrkA(G595R) kinase in complex with N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Descriptor: | High affinity nerve growth factor receptor, N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2023-04-24 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.09192252 Å) | Cite: | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8J5W
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![BU of 8j5w by Molmil](/molmil-images/mine/8j5w) | The crystal structure of TrkA(F589L) kinase in complex with N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Descriptor: | High affinity nerve growth factor receptor, N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2023-04-24 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.28041458 Å) | Cite: | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8J61
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![BU of 8j61 by Molmil](/molmil-images/mine/8j61) | The crystal structure of TrkA kinase in complex with 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Descriptor: | 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide, High affinity nerve growth factor receptor | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2023-04-24 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.05065274 Å) | Cite: | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8J63
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![BU of 8j63 by Molmil](/molmil-images/mine/8j63) | The crystal structure of TrkA kinase in complex with 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Descriptor: | 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide, High affinity nerve growth factor receptor | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2023-04-24 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.0005 Å) | Cite: | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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3RHA
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![BU of 3rha by Molmil](/molmil-images/mine/3rha) | |
8JGD
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![BU of 8jgd by Molmil](/molmil-images/mine/8jgd) | GDP-bound KRAS G12C in complex with YK-8S | Descriptor: | (2~{S})-1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-2-oxidanyl-propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Zhang, Z.M, Wang, R.L. | Deposit date: | 2023-05-20 | Release date: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.60037053 Å) | Cite: | Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145, 2023
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8JHL
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![BU of 8jhl by Molmil](/molmil-images/mine/8jhl) | GDP-bound KRAS G12D in complex with YK-8S | Descriptor: | 1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-3-oxidanyl-propan-1-one, GTPase KRas, N-terminally processed, ... | Authors: | Zhang, Z.M, Wang, R.L. | Deposit date: | 2023-05-23 | Release date: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.10004044 Å) | Cite: | Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145, 2023
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5N80
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![BU of 5n80 by Molmil](/molmil-images/mine/5n80) | |
3U9L
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![BU of 3u9l by Molmil](/molmil-images/mine/3u9l) | The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) from Sinorhizobium meliloti | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] reductase | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-10-19 | Release date: | 2011-11-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) from Sinorhizobium meliloti TO BE PUBLISHED
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5C6D
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![BU of 5c6d by Molmil](/molmil-images/mine/5c6d) | Crystal structure of USP7 in complex with UHRF1 | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Zhang, Z.-M, Song, J. | Deposit date: | 2015-06-22 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.292 Å) | Cite: | An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep, 12, 2015
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3RH9
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![BU of 3rh9 by Molmil](/molmil-images/mine/3rh9) | |
3RYS
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![BU of 3rys by Molmil](/molmil-images/mine/3rys) | |
3S6J
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![BU of 3s6j by Molmil](/molmil-images/mine/3s6j) | The crystal structure of a hydrolase from Pseudomonas syringae | Descriptor: | CALCIUM ION, Hydrolase, haloacid dehalogenase-like family | Authors: | Zhang, Z, Syed Ibrahim, B, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2011-05-25 | Release date: | 2011-07-13 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | The crystal structure of a hydrolase from Pseudomonas syringae To be Published
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8DMR
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![BU of 8dmr by Molmil](/molmil-images/mine/8dmr) | |
7U32
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![BU of 7u32 by Molmil](/molmil-images/mine/7u32) | MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution | Descriptor: | CALCIUM ION, DNA EV272, DNA EV273, ... | Authors: | Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D. | Deposit date: | 2022-02-25 | Release date: | 2022-05-11 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Multivalent interactions essential for lentiviral integrase function. Nat Commun, 13, 2022
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5KLQ
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![BU of 5klq by Molmil](/molmil-images/mine/5klq) | Crystal structure of HopZ1a in complex with IP6 and CoA | Descriptor: | CITRIC ACID, COENZYME A, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, Z.-M, Song, J. | Deposit date: | 2016-06-24 | Release date: | 2016-08-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family. Nat.Struct.Mol.Biol., 23, 2016
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3UBO
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![BU of 3ubo by Molmil](/molmil-images/mine/3ubo) | The crystal structure of adenosine kinase from Sinorhizobium meliloti | Descriptor: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, adenosine kinase | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-10-24 | Release date: | 2011-11-09 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | The crystal structure of adenosine kinase from Sinorhizobium meliloti To be Published
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3U9I
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![BU of 3u9i by Molmil](/molmil-images/mine/3u9i) | The crystal structure of Mandelate racemase/muconate lactonizing enzyme from Roseiflexus sp. | Descriptor: | Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein, SULFATE ION | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-10-19 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of Mandelate racemase/muconate lactonizing enzyme from Roseiflexus sp. TO BE PUBLISHED
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5KLP
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![BU of 5klp by Molmil](/molmil-images/mine/5klp) | Crystal structure of HopZ1a in complex with IP6 | Descriptor: | CITRIC ACID, INOSITOL HEXAKISPHOSPHATE, Orf34 | Authors: | Zhang, Z.-M, Song, J. | Deposit date: | 2016-06-24 | Release date: | 2016-08-10 | Last modified: | 2020-10-14 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family. Nat.Struct.Mol.Biol., 23, 2016
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3T4W
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![BU of 3t4w by Molmil](/molmil-images/mine/3t4w) | The crystal structure of mandelate racemase/muconate lactonizing enzyme from Sulfitobacter sp | Descriptor: | Mandelate racemase/muconate lactonizing enzyme family protein | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-07-26 | Release date: | 2011-08-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.522 Å) | Cite: | The crystal structure of mandelate racemase/muconate lactonizing enzyme from Sulfitobacter sp To be Published
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7UZM
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![BU of 7uzm by Molmil](/molmil-images/mine/7uzm) | Glutamate dehydrogenase 1 from human liver | Descriptor: | Glutamate dehydrogenase 1, mitochondrial | Authors: | Zhang, Z. | Deposit date: | 2022-05-09 | Release date: | 2023-05-03 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | High-resolution structural-omics of human liver enzymes. Cell Rep, 42, 2023
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3RAZ
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![BU of 3raz by Molmil](/molmil-images/mine/3raz) | |
4DGS
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![BU of 4dgs by Molmil](/molmil-images/mine/4dgs) | The crystals structure of dehydrogenase from Rhizobium meliloti | Descriptor: | Dehydrogenase | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, Lafleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2012-01-26 | Release date: | 2012-02-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystals structure of dehydrogenase from Rhizobium meliloti To be Published
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