8XJO
| U46619 bound Thromboxane A2 receptor-Gq Protein Complex | Descriptor: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | Authors: | Zhang, X, Li, X, Liu, G, Gong, W. | Deposit date: | 2023-12-21 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJN
| Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex | Descriptor: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | Authors: | Zhang, X, Li, X, Liu, G, Gong, W. | Deposit date: | 2023-12-21 | Release date: | 2024-02-28 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJL
| PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex | Descriptor: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | Authors: | Zhang, X, Li, X, Liu, G, Gong, W. | Deposit date: | 2023-12-21 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJM
| Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex | Descriptor: | Antibody fragment scFv16, Engineered miniGq, Fusion tag,Prostaglandin F2-alpha receptor,LgBiT, ... | Authors: | Zhang, X, Li, X, Liu, G, Gong, W. | Deposit date: | 2023-12-21 | Release date: | 2024-02-28 | Last modified: | 2024-10-23 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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7EVN
| The cryo-EM structure of the DDX42-SF3b complex | Descriptor: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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7EVO
| The cryo-EM structure of the human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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5XJC
| Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | Deposit date: | 2017-04-30 | Release date: | 2017-07-05 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | An Atomic Structure of the Human Spliceosome Cell, 169, 2017
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2RFD
| Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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4DSB
| Complex Structure of Abscisic Acid Receptor PYL3 with (+)-ABA in Spacegroup of I 212121 at 2.70A | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3 | Authors: | Zhang, X, Zhang, Q, Chen, Z. | Deposit date: | 2012-02-18 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism Structure, 20, 2012
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4DSC
| Complex structure of abscisic acid receptor PYL3 with (+)-ABA in spacegroup of H32 at 1.95A | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3, MAGNESIUM ION | Authors: | Zhang, X, Chen, Z. | Deposit date: | 2012-02-18 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism Structure, 20, 2012
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5GQH
| Cryo-EM structure of PaeCas3-AcrF3 complex | Descriptor: | CRISPR-associated nuclease/helicase Cas3 subtype I-F/YPEST, anti-CRISPR protein 3 | Authors: | Zhang, X, Ma, J, Wang, Y, Wang, J. | Deposit date: | 2016-08-07 | Release date: | 2016-09-21 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses Cell Res., 26, 2016
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2Y3A
| Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 | Descriptor: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM | Authors: | Zhang, X, Vadas, O, Perisic, O, Williams, R.L. | Deposit date: | 2010-12-20 | Release date: | 2011-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41, 2011
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6ID1
| Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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5HWL
| Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form | Descriptor: | GLUTATHIONE, Glutathione S-transferase Mu 2, N,N'-(butane-1,4-diyl)bis{2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide} | Authors: | Zhang, X, Wei, J, Wu, S, Zhang, H.P, Luo, M, Yang, X.L, Liao, F, Wang, D.Q. | Deposit date: | 2016-01-29 | Release date: | 2017-11-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form To Be Published
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3J27
| CryoEM structure of Dengue virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | Authors: | Zhang, X, Ge, P, Yu, X, Brannan, J.M, Bi, G, Zhang, Q, Schein, S, Zhou, Z.H. | Deposit date: | 2012-09-26 | Release date: | 2012-12-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Nat.Struct.Mol.Biol., 20, 2012
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1NPU
| CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1 | Descriptor: | Programmed cell death protein 1 | Authors: | Zhang, X, Schwartz, J.-C.D, Guo, X, Cao, E, Chen, L, Zhang, Z.-Y, Nathenson, S.G, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-01-20 | Release date: | 2004-03-23 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity, 20, 2004
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5GTX
| Crystal structure of mutated buckwheat glutaredoxin | Descriptor: | buckwheat glutaredoxin | Authors: | Zhang, X, Wang, W, Zhao, Y, Wang, Z, Wang, H. | Deposit date: | 2016-08-23 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity J. Inorg. Biochem., 173, 2017
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6ID0
| Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6ICZ
| Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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1UON
| REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*GP*GP*GP*GP*GP*)-3', 5'-R(*UP*AP*GP*CP*CP*CP*CP*CP*)-3', ... | Authors: | Zhang, X, Walker, S.B, Chipman, P.R, Nibert, M.L, Baker, T.S. | Deposit date: | 2003-09-21 | Release date: | 2003-11-13 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Reovirus Polymerase Lambda3 Localized by Cryo-Electron Microscopy of Virions at a Resolution of 7.6 A Nat.Struct.Biol., 10, 2003
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3J2P
| CryoEM structure of Dengue virus envelope protein heterotetramer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | Authors: | Zhang, X, Ge, P, Yu, X, Brannan, J.M, Bi, G, Zhang, Q, Schein, S, Zhou, Z.H. | Deposit date: | 2012-11-30 | Release date: | 2012-12-19 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Nat.Struct.Mol.Biol., 20, 2012
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8H0Z
| Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-122 Conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | Authors: | Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X. | Deposit date: | 2022-09-30 | Release date: | 2022-11-09 | Last modified: | 2024-10-23 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance, 6, 2023
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8UEL
| Crystal structure of enolase from Litopenaeus vannamei | Descriptor: | Enolase, MAGNESIUM ION, PHOSPHOENOLPYRUVATE, ... | Authors: | Chang, X, Zhao, G. | Deposit date: | 2023-10-01 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Characterization and Structural Analyses of Enolase from Shrimp ( Litopenaeus vannamei ). J.Agric.Food Chem., 71, 2023
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3IYK
| Bluetongue virus structure reveals a sialic acid binding domain, amphipathic helices and a central coiled coil in the outer capsid proteins | Descriptor: | 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, VP2, VP5 | Authors: | Zhang, X, Boyce, M, Bhattacharya, B, Zhang, X, Schein, S, Roy, P, Zhou, Z.H. | Deposit date: | 2010-01-25 | Release date: | 2010-04-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins. Proc.Natl.Acad.Sci.USA, 107, 2010
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8G05
| Cryo-EM structure of an orphan GPCR-Gi protein signaling complex | Descriptor: | 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... | Authors: | Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. | Deposit date: | 2023-01-31 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Pro-phagocytic function and structural basis of GPR84 signaling. Nat Commun, 14, 2023
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