8Z5C
 
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8Z5D
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8Z5E
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9C49
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8Z5F
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6TGC
 | | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | | 分子名称: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | | 登録日 | 2019-11-15 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
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7N61
 | | structure of C2 projections and MIPs | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FAP147, FAP178, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-07 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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7N6G
 | | C1 of central pair | | 分子名称: | CPC1, Calmodulin, DPY30, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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1HQ3
 | | CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE | | 分子名称: | CHLORIDE ION, HISTONE H2A-IV, HISTONE H2B, ... | | 著者 | Chantalat, L, Nicholson, J.M, Lambert, S.J, Reid, A.J, Donovan, M.J, Reynolds, C.D, Wood, C.M, Baldwin, J.P. | | 登録日 | 2000-12-14 | | 公開日 | 2001-01-24 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structure of the histone-core octamer in KCl/phosphate crystals at 2.15 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
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2PQE
 | | Solution structure of proline-free mutant of staphylococcal nuclease | | 分子名称: | Thermonuclease | | 著者 | Shan, L, Tong, Y, Xie, T, Wang, M, Wang, J. | | 登録日 | 2007-05-01 | | 公開日 | 2007-06-19 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease.
Biochemistry, 46, 2007
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6KXW
 | | Crystal structure of human aquaporin AQP7 in bound to glycerol | | 分子名称: | Aquaporin-7, GLYCEROL | | 著者 | Zhang, L, Yao, D, Zhou, F, Zhang, Q, Zhou, L, Cao, Y. | | 登録日 | 2019-09-13 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | The structural basis for glycerol permeation by human AQP7
Sci Bull (Beijing), 66, 2020
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5XPD
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7XMK
 | | Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923 | | 分子名称: | 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | | 著者 | Zhang, L, Wang, Y, Li, Y, Yang, S. | | 登録日 | 2022-04-26 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.376 Å) | | 主引用文献 | From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.
J.Med.Chem., 67, 2024
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6LKQ
 | | The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Zhang, L, Wang, Y.H, Lancaster, L, Zhou, J, Noller, H.F. | | 登録日 | 2019-12-20 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | The structural basis for inhibition of ribosomal translocation by viomycin.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8JU8
 | | de novo designed protein | | 分子名称: | de novo designed protein | | 著者 | Zhang, L. | | 登録日 | 2023-06-25 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | de novo designed Rossmann fold protein
To Be Published
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7N3O
 | | Cryo-EM structure of the Cas12k-sgRNA complex | | 分子名称: | Cas12k, Single guide RNA | | 著者 | Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. | | 登録日 | 2021-06-01 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.
Mol.Cell, 81, 2021
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7N3P
 | | Cryo-EM structure of the Cas12k-sgRNA-dsDNA complex | | 分子名称: | Cas12k, DNA (5'-D(*CP*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*AP*AP*CP*CP*GP*AP*GP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*CP*TP*CP*GP*GP*TP*T)-3'), ... | | 著者 | Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. | | 登録日 | 2021-06-01 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.
Mol.Cell, 81, 2021
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9BW1
 | | TnsABCD-DNA transpososome | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Integrase, LE_polyA, ... | | 著者 | Chang, L, Wang, S. | | 登録日 | 2024-05-20 | | 公開日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition.
Cell, 2024
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6LIR
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7N7V
 | | Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes at 2 A. | | 分子名称: | CHLORIDE ION, FE (II) ION, Predicted hydroxylase | | 著者 | Han, L, Xu, W, Ma, M, Miller, M.D, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2021-06-11 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes.
To Be Published
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8ZAV
 | | alcohol dehydrogenases KpADH mutant - S9Y/F161K | | 分子名称: | 1,2-ETHANEDIOL, NAD-dependent epimerase/dehydratase domain-containing protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zhang, L, Ni, Y, Xu, G.C. | | 登録日 | 2024-04-25 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Engineering alcohol dehydrogenases KpADH for enhanced organic-solvent tolerance and its molecular mechanisms
To Be Published
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5VFA
 | | RitR Mutant - C128D | | 分子名称: | Response regulator | | 著者 | Han, L, Silvaggi, N.R. | | 登録日 | 2017-04-07 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.452 Å) | | 主引用文献 | RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
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5U8M
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5BK7
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7YSE
 | | Crystal structure of E. coli heterotetrameric GlyRS in complex with tRNA | | 分子名称: | Glycine--tRNA ligase alpha subunit, Glycine--tRNA ligase beta subunit, MAGNESIUM ION, ... | | 著者 | Han, L, Ju, Y, Zhou, H. | | 登録日 | 2022-08-12 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.907 Å) | | 主引用文献 | The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements.
Sci Adv, 9, 2023
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