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PDB: 782 件

8Z5C
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Cystal structure of beta-ketoacyl-ACP synthase FabF from Helicobacter pylori
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, RUBIDIUM ION
著者Zhang, L, Huang, Y.Z.
登録日2024-04-18
公開日2024-10-09
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The beta-Ketoacyl-ACP Synthase FabF Catalyzes Carbon-Carbon Bond Formation in a Bimodal Pattern for Fatty Acid Biosynthesis.
Angew.Chem.Int.Ed.Engl., 2024
8Z5D
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Crystal structure of beta-ketoacyl-ACP synthase FabF K336A in complex with hexanoyl-ACP from Helicobacter pylori
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, HEXANOIC ACID, ...
著者Zhang, L, Huang, Y.Z.
登録日2024-04-18
公開日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The beta-Ketoacyl-ACP Synthase FabF Catalyzes Carbon-Carbon Bond Formation in a Bimodal Pattern for Fatty Acid Biosynthesis.
Angew.Chem.Int.Ed.Engl., 2024
8Z5E
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BU of 8z5e by Molmil
Crystal structure of beta-ketoacyl-ACP synthase FabF K336A in complex with octanoyl-ACP from Helicobacter pylori
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide, ...
著者Zhang, L, Huang, Y.Z.
登録日2024-04-18
公開日2024-10-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The beta-Ketoacyl-ACP Synthase FabF Catalyzes Carbon-Carbon Bond Formation in a Bimodal Pattern for Fatty Acid Biosynthesis.
Angew.Chem.Int.Ed.Engl., 2024
9C49
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Cryo-EM structure of Danio rerio voltage-sensing phosphatase (VSP) phosphatase domain
分子名称: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
著者Zhang, L, Brohawn, S.G.
登録日2024-06-03
公開日2024-07-10
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Coupling sensor to enzyme in the voltage sensing phosphatase.
Nat Commun, 15, 2024
8Z5F
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Crystal structure of beta-ketoacyl-ACP synthase FabF K336A in complex with decanoyl-ACP from Helicobacter pylori
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, DECANOIC ACID, ...
著者Zhang, L, Huang, Y.Z.
登録日2024-04-18
公開日2024-10-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The beta-Ketoacyl-ACP Synthase FabF Catalyzes Carbon-Carbon Bond Formation in a Bimodal Pattern for Fatty Acid Biosynthesis.
Angew.Chem.Int.Ed.Engl., 2024
6TGC
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BU of 6tgc by Molmil
CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex.
分子名称: Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1
著者Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D.
登録日2019-11-15
公開日2020-07-29
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
7N61
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structure of C2 projections and MIPs
分子名称: ADENOSINE-5'-DIPHOSPHATE, FAP147, FAP178, ...
著者Han, L, Zhang, K.
登録日2021-06-07
公開日2022-05-18
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
7N6G
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C1 of central pair
分子名称: CPC1, Calmodulin, DPY30, ...
著者Han, L, Zhang, K.
登録日2021-06-08
公開日2022-05-18
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
1HQ3
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CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE
分子名称: CHLORIDE ION, HISTONE H2A-IV, HISTONE H2B, ...
著者Chantalat, L, Nicholson, J.M, Lambert, S.J, Reid, A.J, Donovan, M.J, Reynolds, C.D, Wood, C.M, Baldwin, J.P.
登録日2000-12-14
公開日2001-01-24
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of the histone-core octamer in KCl/phosphate crystals at 2.15 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
2PQE
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Solution structure of proline-free mutant of staphylococcal nuclease
分子名称: Thermonuclease
著者Shan, L, Tong, Y, Xie, T, Wang, M, Wang, J.
登録日2007-05-01
公開日2007-06-19
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease.
Biochemistry, 46, 2007
6KXW
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Crystal structure of human aquaporin AQP7 in bound to glycerol
分子名称: Aquaporin-7, GLYCEROL
著者Zhang, L, Yao, D, Zhou, F, Zhang, Q, Zhou, L, Cao, Y.
登録日2019-09-13
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献The structural basis for glycerol permeation by human AQP7
Sci Bull (Beijing), 66, 2020
5XPD
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Sugar transporter of AtSWEET13 in inward-facing state with a substrate analog
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, sugar transporter
著者Han, L, Zhang, X.J.
登録日2017-06-01
公開日2017-09-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.788 Å)
主引用文献Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7XMK
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BU of 7xmk by Molmil
Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923
分子名称: 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1
著者Zhang, L, Wang, Y, Li, Y, Yang, S.
登録日2022-04-26
公開日2023-04-26
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.376 Å)
主引用文献From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.
J.Med.Chem., 67, 2024
6LKQ
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The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Zhang, L, Wang, Y.H, Lancaster, L, Zhou, J, Noller, H.F.
登録日2019-12-20
公開日2020-05-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The structural basis for inhibition of ribosomal translocation by viomycin.
Proc.Natl.Acad.Sci.USA, 117, 2020
8JU8
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BU of 8ju8 by Molmil
de novo designed protein
分子名称: de novo designed protein
著者Zhang, L.
登録日2023-06-25
公開日2023-07-26
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献de novo designed Rossmann fold protein
To Be Published
7N3O
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BU of 7n3o by Molmil
Cryo-EM structure of the Cas12k-sgRNA complex
分子名称: Cas12k, Single guide RNA
著者Chang, L, Li, Z, Xiao, R, Wang, S, Han, R.
登録日2021-06-01
公開日2021-09-01
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.
Mol.Cell, 81, 2021
7N3P
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Cryo-EM structure of the Cas12k-sgRNA-dsDNA complex
分子名称: Cas12k, DNA (5'-D(*CP*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*AP*AP*CP*CP*GP*AP*GP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*CP*TP*CP*GP*GP*TP*T)-3'), ...
著者Chang, L, Li, Z, Xiao, R, Wang, S, Han, R.
登録日2021-06-01
公開日2021-09-01
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.
Mol.Cell, 81, 2021
9BW1
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BU of 9bw1 by Molmil
TnsABCD-DNA transpososome
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Integrase, LE_polyA, ...
著者Chang, L, Wang, S.
登録日2024-05-20
公開日2024-10-16
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition.
Cell, 2024
6LIR
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BU of 6lir by Molmil
crystal structure of chicken TCR for 2.0
分子名称: TCR alpha chain, TCR beta chain
著者Zhang, L, Xia, C.
登録日2019-12-12
公開日2020-11-18
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.091 Å)
主引用文献Structural and Biophysical Insights into the TCR alpha beta Complex in Chickens.
Iscience, 23, 2020
7N7V
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BU of 7n7v by Molmil
Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes at 2 A.
分子名称: CHLORIDE ION, FE (II) ION, Predicted hydroxylase
著者Han, L, Xu, W, Ma, M, Miller, M.D, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2021-06-11
公開日2022-07-06
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes.
To Be Published
8ZAV
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BU of 8zav by Molmil
alcohol dehydrogenases KpADH mutant - S9Y/F161K
分子名称: 1,2-ETHANEDIOL, NAD-dependent epimerase/dehydratase domain-containing protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L, Ni, Y, Xu, G.C.
登録日2024-04-25
公開日2024-06-26
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Engineering alcohol dehydrogenases KpADH for enhanced organic-solvent tolerance and its molecular mechanisms
To Be Published
5VFA
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BU of 5vfa by Molmil
RitR Mutant - C128D
分子名称: Response regulator
著者Han, L, Silvaggi, N.R.
登録日2017-04-07
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.452 Å)
主引用文献RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
5U8M
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A novel family of redox sensors in the streptococci evolved from two-component response regulators
分子名称: Response regulator
著者Han, L, Silvaggi, N.R.
登録日2016-12-14
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.105 Å)
主引用文献RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
5BK7
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The structure of MppP E15A mutant soaked with the substrate L-arginine
分子名称: (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, PLP-Dependent L-Arginine Hydroxylase MppP
著者Han, L, Silvaggi, N.R.
登録日2018-01-27
公開日2018-09-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.196 Å)
主引用文献Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
7YSE
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Crystal structure of E. coli heterotetrameric GlyRS in complex with tRNA
分子名称: Glycine--tRNA ligase alpha subunit, Glycine--tRNA ligase beta subunit, MAGNESIUM ION, ...
著者Han, L, Ju, Y, Zhou, H.
登録日2022-08-12
公開日2023-02-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.907 Å)
主引用文献The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements.
Sci Adv, 9, 2023

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件を2024-10-30に公開中

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