4ZUD
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![BU of 4zud by Molmil](/molmil-images/mine/4zud) | Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution. | 分子名称: | Chimera protein of Soluble cytochrome b562 and Type-1 angiotensin II receptor, Olmesartan | 著者 | Zhang, H, Unal, H, Desnoyer, R, Han, G.W, Patel, N, Katritch, V, Karnik, S.S, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | 登録日 | 2015-05-15 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J.Biol.Chem., 290, 2015
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1VQI
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![BU of 1vqi by Molmil](/molmil-images/mine/1vqi) | GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY VAL 47 (I47V) | 分子名称: | GENE V PROTEIN | 著者 | Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. | 登録日 | 1996-08-14 | 公開日 | 1997-02-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
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1VQF
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![BU of 1vqf by Molmil](/molmil-images/mine/1vqf) | GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY VAL 47 (V35I, I47V) | 分子名称: | GENE V PROTEIN | 著者 | Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. | 登録日 | 1996-08-14 | 公開日 | 1997-02-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
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8Y8Z
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![BU of 8y8z by Molmil](/molmil-images/mine/8y8z) | Structure of NET-Maprotiline in outward-open state | 分子名称: | CHLORIDE ION, SODIUM ION, Sodium-dependent noradrenaline transporter, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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1W2X
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![BU of 1w2x by Molmil](/molmil-images/mine/1w2x) | Crystal structure of the carboxyltransferase domain of acetyl- coenzyme A carboxylase in complex with CP-640186 | 分子名称: | (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, ACETYL-COA CARBOXYLASE | 著者 | Zhang, H, Tweel, B, Li, J, Tong, L. | 登録日 | 2004-07-09 | 公開日 | 2004-09-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Carboxyltransferase Domain of Acetyl-Coenzyme a Carboxylase in Complex with Cp-640186 Structure, 12, 2004
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8Y94
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![BU of 8y94 by Molmil](/molmil-images/mine/8y94) | |
8W56
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![BU of 8w56 by Molmil](/molmil-images/mine/8w56) | Cryo-EM structure of DSR2-DSAD1 state 1 | 分子名称: | SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI | 著者 | Zhang, H, Li, Z, Li, X.Z. | 登録日 | 2023-08-25 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Insights into the modulation of bacterial NADase activity by phage proteins. Nat Commun, 15, 2024
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8WKN
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![BU of 8wkn by Molmil](/molmil-images/mine/8wkn) | Cryo-EM structure of DSR2-DSAD1 | 分子名称: | SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI | 著者 | Zhang, H, Li, Z, Li, X.Z. | 登録日 | 2023-09-28 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Insights into the modulation of bacterial NADase activity by phage proteins. Nat Commun, 15, 2024
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8WFN
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8I87
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![BU of 8i87 by Molmil](/molmil-images/mine/8i87) | Cryo-EM structure of TIR-APAZ/Ago-gRNA-DNA complex | 分子名称: | DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*A)-3'), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Zhang, H, Deng, Z.Q, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-02-03 | 公開日 | 2023-07-19 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
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8X73
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![BU of 8x73 by Molmil](/molmil-images/mine/8x73) | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | 分子名称: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | 著者 | Zhang, H, Luo, C. | 登録日 | 2023-11-22 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8X71
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![BU of 8x71 by Molmil](/molmil-images/mine/8x71) | Crystal structure of Peroxiredoxin I in complex with compound 19-064 | 分子名称: | Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate | 著者 | Zhang, H, Luo, C. | 登録日 | 2023-11-22 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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1E4U
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![BU of 1e4u by Molmil](/molmil-images/mine/1e4u) | N-terminal RING finger domain of human NOT-4 | 分子名称: | TRANSCRIPTIONAL REPRESSOR NOT4, ZINC ION | 著者 | Hanzawa, H, De Ruwe, M.J, Albert, T.K, Van Der Vliet, P.C, Timmers, H.T, Boelens, R. | 登録日 | 2000-07-12 | 公開日 | 2001-03-31 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Structure of the C4C4 Ring Finger of Human not4 Reveals Features Distinct from Those of C3Hc4 Ring Fingers J.Biol.Chem., 276, 2001
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8YR2
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![BU of 8yr2 by Molmil](/molmil-images/mine/8yr2) | Structure of NET-Nisoxetine in outward-open state | 分子名称: | CHLORIDE ION, CHOLESTEROL, SODIUM ION, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-03-20 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8Y91
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![BU of 8y91 by Molmil](/molmil-images/mine/8y91) | Structure of NET-nomifensine in outward-open state | 分子名称: | (4S)-2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine, CHLORIDE ION, SODIUM ION, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8Y92
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![BU of 8y92 by Molmil](/molmil-images/mine/8y92) | structure of NET-Atomoxetine in outward-open state | 分子名称: | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, SODIUM ION, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8Y95
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![BU of 8y95 by Molmil](/molmil-images/mine/8y95) | Structure of NET-NE in Occluded state | 分子名称: | CHLORIDE ION, Noradrenaline, SODIUM ION, ... | 著者 | Zhang, H, Xu, H.E, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8ITE
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![BU of 8ite by Molmil](/molmil-images/mine/8ite) | |
8Y90
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![BU of 8y90 by Molmil](/molmil-images/mine/8y90) | Structure of NET-Nefopam in outward-open state | 分子名称: | (1S)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine, CHLORIDE ION, SODIUM ION, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8Y93
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![BU of 8y93 by Molmil](/molmil-images/mine/8y93) | Structure of NET-Amitriptyline in outward-open state | 分子名称: | Amitriptyline, CHLORIDE ION, SODIUM ION, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8XKN
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8IN8
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![BU of 8in8 by Molmil](/molmil-images/mine/8in8) | Cryo-EM structure of the target ssDNA-bound SIR2-APAZ/Ago-gRNA quaternary complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*GP*AP*CP*GP*TP*CP*TP*AP*AP*GP*AP*AP*AP*CP*CP*AP*TP*TP*AP*A)-3'), MAGNESIUM ION, Piwi domain protein, ... | 著者 | Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-03-08 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
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8I88
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![BU of 8i88 by Molmil](/molmil-images/mine/8i88) | Cryo-EM structure of TIR-APAZ/Ago-gRNA complex | 分子名称: | Piwi domain-containing protein, RNA (5'-R(P*GP*A)-3'), TIR domain-containing protein | 著者 | Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-02-03 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
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8HYJ
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8IFG
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![BU of 8ifg by Molmil](/molmil-images/mine/8ifg) | Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe | 分子名称: | Chromatin modification-related protein eaf3, Cph1, Cph2, ... | 著者 | Zhang, H.Q, Wang, X, Wang, Y.N, Liu, S.M, Zhang, Y, Xu, K, Ji, L.T, Kornberg, R.D. | 登録日 | 2023-02-17 | 公開日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A, 120, 2023
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