8Y93

Structure of NET-Amitriptyline in outward-open state

Summary for 8Y93

• Entry DOI: 10.2210/pdb8y93/pdb
• EMDB information: 39068
• Descriptor: Sodium-dependent noradrenaline transporter, Amitriptyline, SODIUM ION, ... (4 entities in total)
• Functional Keywords: transporter, transport protein-inhibitor complex, transport protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 139108.94

Authors

Zhang, H.,Xu, E.H.,Jiang, Y. (deposition date: 2024-02-06, release date: 2024-05-29, Last modification date: 2024-07-03)

• Primary citation: Zhang, H.,Yin, Y.L.,Dai, A.,Zhang, T.,Zhang, C.,Wu, C.,Hu, W.,He, X.,Pan, B.,Jin, S.,Yuan, Q.,Wang, M.W.,Yang, D.,Xu, H.E.,Jiang, Y.; Dimerization and antidepressant recognition at noradrenaline transporter.; Nature, 630:247-254, 2024; PubMed: 38750358; DOI: 10.1038/s41586-024-07437-6

Experimental method

ELECTRON MICROSCOPY (3 Å)