6JFM
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![BU of 6jfm by Molmil](/molmil-images/mine/6jfm) | Mitofusin2 (MFN2)_T111D | Descriptor: | ACETATE ION, CALCIUM ION, Mitofusin-2,Mitofusin-2 | Authors: | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | Deposit date: | 2019-02-10 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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5FU7
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![BU of 5fu7 by Molmil](/molmil-images/mine/5fu7) | drosophila nanos NBR peptide bound to the NOT module of the human CCR4-NOT complex | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3, ... | Authors: | Raisch, T, Bhandari, D, Sabath, K, Helms, S, Valkov, E, Weichenrieder, O, Izaurralde, E. | Deposit date: | 2016-01-21 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos Embo J., 35, 2016
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7LHG
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![BU of 7lhg by Molmil](/molmil-images/mine/7lhg) | Cryo-EM structure of E. coli P pilus tip assembly intermediate PapC-PapD-PapK-PapG in the first conformation | Descriptor: | Chaperone protein PapD, Fimbrial adapter PapK, P fimbria tip G-adhesin PapG-II, ... | Authors: | Du, M, Yuan, Z, Werneburg, G, Henderson, N, Chauhan, H, Kovach, A, Zhao, G, Johl, J, Li, H, Thanassi, D. | Deposit date: | 2021-01-23 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis. Nat Commun, 12, 2021
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7LHH
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![BU of 7lhh by Molmil](/molmil-images/mine/7lhh) | Cryo-EM structure of E. coli P pilus tip assembly intermediate PapC-PapD-PapK-PapG in the second conformation | Descriptor: | Chaperone protein PapD, Fimbrial adapter PapK, P fimbria tip G-adhesin PapG-II, ... | Authors: | Du, M, Yuan, Z, Werneburg, G, Henderson, N, Chauhan, H, Kovach, A, Zhao, G, Johl, J, Li, H, Thanassi, D. | Deposit date: | 2021-01-23 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis. Nat Commun, 12, 2021
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7LHI
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![BU of 7lhi by Molmil](/molmil-images/mine/7lhi) | Cryo-EM structure of E. coli P pilus tip assembly intermediate PapC-PapD-PapK-PapF-PapG | Descriptor: | Chaperone protein PapD, Fimbrial adapter PapK, Fimbrial protein, ... | Authors: | Du, M, Yuan, Z, Werneburg, G, Henderson, N, Chauhan, H, Kovach, A, Zhao, G, Johl, J, Li, H, Thanassi, D. | Deposit date: | 2021-01-23 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis. Nat Commun, 12, 2021
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6G32
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![BU of 6g32 by Molmil](/molmil-images/mine/6g32) | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y | Descriptor: | GLYCEROL, Geranylgeranyl pyrophosphate synthase | Authors: | Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y. | Deposit date: | 2018-03-24 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.281 Å) | Cite: | Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Mol. Pharmacol., 94, 2018
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6G31
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![BU of 6g31 by Molmil](/molmil-images/mine/6g31) | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate | Descriptor: | Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID | Authors: | Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y. | Deposit date: | 2018-03-24 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Mol. Pharmacol., 94, 2018
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2KIS
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![BU of 2kis by Molmil](/molmil-images/mine/2kis) | Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker | Descriptor: | Transcription elongation regulator 1 | Authors: | Murphy, J.M, Hansen, D, Wiesner, S, Muhandiram, D, Borg, M, Smith, M.J, Sicheri, F, Kay, L.E, Forman-Kay, J.D, Pawson, T. | Deposit date: | 2009-05-08 | Release date: | 2009-09-08 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. J.Mol.Biol., 393, 2009
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7DWV
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![BU of 7dwv by Molmil](/molmil-images/mine/7dwv) | Cryo-EM structure of amyloid fibril formed by familial prion disease-related mutation E196K | Descriptor: | Major prion protein | Authors: | Wang, L.Q, Zhao, K, Yuan, H.Y, Li, X.N, Dang, H.B, Ma, Y.Y, Wang, Q, Wang, C, Sun, Y.P, Chen, J, Li, D, Zhang, D.L, Yin, P, Liu, C, Liang, Y. | Deposit date: | 2021-01-18 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Sci Adv, 7, 2021
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4NOD
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![BU of 4nod by Molmil](/molmil-images/mine/4nod) | Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation | Descriptor: | 5'-D(*CP*CP*AP*AP*CP*CP*AP*AP*GP*CP*CP*CP*CP*AP*TP*AP*CP*CP*CP*CP*AP*A)-3', 5'-D(*TP*TP*GP*GP*GP*GP*TP*AP*TP*GP*GP*GP*GP*CP*TP*TP*GP*GP*(BRU)P*TP*GP*G)-3', Transcription factor A, ... | Authors: | Ngo, H.B, Lovely, G.A, Phillips, R, Chan, D.C. | Deposit date: | 2013-11-19 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.897 Å) | Cite: | Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nat Commun, 5, 2014
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2I9T
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![BU of 2i9t by Molmil](/molmil-images/mine/2i9t) | Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter | Descriptor: | 5'-D(*AP*GP*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*CP*TP*G)-3', 5'-D(*CP*AP*GP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*CP*AP*CP*T)-3', Nuclear factor NF-kappa-B p105 subunit, ... | Authors: | Escalante, C.R, Shen, L, Thanos, D, Aggarwal, A.K. | Deposit date: | 2006-09-06 | Release date: | 2007-02-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter Structure, 10, 2002
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3KA0
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![BU of 3ka0 by Molmil](/molmil-images/mine/3ka0) | |
6DEY
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![BU of 6dey by Molmil](/molmil-images/mine/6dey) | |
4OAH
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![BU of 4oah by Molmil](/molmil-images/mine/4oah) | |
3KC3
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![BU of 3kc3 by Molmil](/molmil-images/mine/3kc3) | MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine | Descriptor: | MAP kinase-activated protein kinase 2, N~4~-[7-(1-benzofuran-2-yl)-1H-indazol-5-yl]pyrimidine-2,4-diamine | Authors: | Argiriadi, M.A, Talanian, R.V, Borhani, D.W. | Deposit date: | 2009-10-20 | Release date: | 2010-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Bioorg.Med.Chem.Lett., 20, 2010
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4NNU
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![BU of 4nnu by Molmil](/molmil-images/mine/4nnu) | Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation | Descriptor: | DNA1, DNA2, Transcription factor A, ... | Authors: | Ngo, H.B, Lovely, G.A, Phillips, R, Chan, D.C. | Deposit date: | 2013-11-19 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nat Commun, 5, 2014
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1CX8
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![BU of 1cx8 by Molmil](/molmil-images/mine/1cx8) | CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SAMARIUM (III) ION, TRANSFERRIN RECEPTOR PROTEIN | Authors: | Lawrence, C.M, Ray, S, Babyonyshev, M, Galluser, R, Borhani, D, Harrison, S.C. | Deposit date: | 1999-08-28 | Release date: | 1999-09-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the ectodomain of human transferrin receptor. Science, 286, 1999
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6E14
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![BU of 6e14 by Molmil](/molmil-images/mine/6e14) | Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD | Descriptor: | Chaperone protein FimC, Fimbrial biogenesis outer membrane usher protein, Protein FimF, ... | Authors: | Du, M, Yuan, Z, Yu, H, Henderson, N, Sarowar, S, Zhao, G, Werneburg, G.T, Thanassi, D.G, Li, H. | Deposit date: | 2018-07-09 | Release date: | 2018-10-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Handover mechanism of the growing pilus by the bacterial outer-membrane usher FimD. Nature, 562, 2018
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7K9P
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![BU of 7k9p by Molmil](/molmil-images/mine/7k9p) | Room temperature structure of NSP15 Endoribonuclease from SARS CoV-2 solved using SFX. | Descriptor: | CITRIC ACID, Uridylate-specific endoribonuclease | Authors: | Botha, S, Jernigan, R, Chen, J, Coleman, M.A, Frank, M, Grant, T.D, Hansen, D.T, Ketawala, G, Logeswaran, D, Martin-Garcia, J, Nagaratnam, N, Raj, A.L.L.X, Shelby, M, Yang, J.-H, Yung, M.C, Fromme, P. | Deposit date: | 2020-09-29 | Release date: | 2020-10-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser. Structure, 2022
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4OAG
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![BU of 4oag by Molmil](/molmil-images/mine/4oag) | |
4OAF
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![BU of 4oaf by Molmil](/molmil-images/mine/4oaf) | |
7E44
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![BU of 7e44 by Molmil](/molmil-images/mine/7e44) | Crystal structure of NudC complexed with dpCoA | Descriptor: | DEPHOSPHO COENZYME A, NADH pyrophosphatase, ZINC ION | Authors: | Zhou, W, Guan, Z.Y, Yin, P, Zhang, D.L. | Deposit date: | 2021-02-10 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into dpCoA-RNA decapping by NudC. Rna Biol., 18, 2021
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7F6H
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![BU of 7f6h by Molmil](/molmil-images/mine/7f6h) | Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin | Descriptor: | Bradykinin, Bradykinin receptor BK2R, CHOLESTEROL, ... | Authors: | Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. | Deposit date: | 2021-06-25 | Release date: | 2022-01-05 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
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7F6I
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![BU of 7f6i by Molmil](/molmil-images/mine/7f6i) | Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin | Descriptor: | Bradykinin receptor BK2R, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. | Deposit date: | 2021-06-25 | Release date: | 2022-01-05 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
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2FFR
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![BU of 2ffr by Molmil](/molmil-images/mine/2ffr) | Crystallographic studies on N-azido-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: comparison with N-acetyl-beta-D-glucopyranosylamine | Descriptor: | Glycogen phosphorylase, muscle form, N-(azidoacetyl)-beta-D-glucopyranosylamine, ... | Authors: | Petsalakis, E.I, Chrysina, E.D, Tiraidis, C, Hadjiloi, T, Leonidas, D.D, Oikonomakos, N.G, Aich, U, Varghese, B, Loganathan, D. | Deposit date: | 2005-12-20 | Release date: | 2006-06-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystallographic studies on N-azidoacetyl-beta-d-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-beta-d-glucopyranosylamine. Bioorg.Med.Chem., 14, 2006
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