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PDB: 34 件
3U9W
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Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Niegowski, D, Thunnissen, M, Tholander, F, Rinaldo-Matthis, A, Muroya, A, Haeggstrom, J.Z.
登録日2011-10-20
公開日2012-10-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
To be Published
7NTM
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BU of 7ntm by Molmil
Cryo-EM structure of S.cerevisiae native alcohol dehydrogenase 1 (ADH1) in its tetrameric apo state
分子名称: Alcohol dehydrogenase 1, ZINC ION
著者Nzigou Mandouckou, J.A, Carroni, M, Haeggstrom, J.Z, Thulasingam, M.
登録日2021-03-10
公開日2022-10-12
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Cryo-EM structure of S.cerevisiae native alcohol dehydrogenase 1 (ADH1) in its tetrameric apo state
To Be Published
5HV9
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BU of 5hv9 by Molmil
Human LTC4S mutant-S36E
分子名称: GLUTATHIONE, Leukotriene C4 synthase, SULFATE ION
著者Thulasingam, M, Ahmad, H.R.S, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2016-01-28
公開日2016-07-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
J.Biol.Chem., 291, 2016
8AVA
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Leukotriene A4 hydrolase in complex with 4-(4-benzylphenyl)-oxazol-2-amine
分子名称: 4-[4-(phenylmethyl)phenyl]-1,3-oxazol-2-amine, ACETATE ION, GLYCEROL, ...
著者Teder, T, Haeggstrom, J.Z.
登録日2022-08-26
公開日2023-05-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.354 Å)
主引用文献Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A 4 Hydrolase.
Int J Mol Sci, 24, 2023
8AWH
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Leukotriene A4 hydrolase in complex with 4-(4-Benzylphenyl)-selenazol-2-amine
分子名称: 4-[4-(phenylmethyl)phenyl]-1,3-selenazol-2-amine, ACETATE ION, GLYCEROL, ...
著者Teder, T, Haeggstrom, J.Z.
登録日2022-08-29
公開日2023-05-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A 4 Hydrolase.
Int J Mol Sci, 24, 2023
2R59
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Leukotriene A4 hydrolase complexed with inhibitor RB3041
分子名称: ACETIC ACID, Leukotriene A-4 hydrolase, N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ...
著者Tholander, F, Haeggstrom, J.Z, Thunnissen, M, Muroya, A, Roques, B.P, Fournie-Zaluski, M.C.
登録日2007-09-03
公開日2008-08-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3HKK
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Structure of human Leukotriene C4 synthase in complex with glutathione sulfonate
分子名称: GLUTATHIONE SULFONIC ACID, Leukotriene C4 synthase, PALMITIC ACID, ...
著者Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2009-05-24
公開日2010-05-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Pre-steady state kinetics of human Leukotriene C4 synthase
To be Published
1GW6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ...
著者Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Samuelsson, B, Haeggstrom, J.Z.
登録日2002-03-07
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375
Proc.Natl.Acad.Sci.USA, 99, 2002
4DPR
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Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril
分子名称: ACETIC ACID, GLYCEROL, L-CAPTOPRIL, ...
著者Stsiapanava, A, Haeggstrom, J.Z, Rinaldo-Matthis, A.
登録日2012-02-14
公開日2013-02-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Capturing LTA4hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4synthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4GAA
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Structure of Leukotriene A4 hydrolase from Xenopus laevis complexed with inhibitor bestatin
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, MGC78867 protein, ZINC ION
著者Stsiapanava, A, Kumar, R.B, Haeggstrom, J.Z, Rinaldo-Matthis, A.
登録日2012-07-25
公開日2013-06-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Biochim.Biophys.Acta, 1844, 2014
1H19
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STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
分子名称: ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ...
著者Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Haeggstrom, J.Z.
登録日2002-07-04
公開日2002-08-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms
J.Biol.Chem., 277, 2002
2XPZ
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Structure of native yeast LTA4 hydrolase
分子名称: (R,R)-2,3-BUTANEDIOL, LEUKOTRIENE A-4 HYDROLASE, POLYETHYLENE GLYCOL (N=34), ...
著者Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M.
登録日2010-08-31
公開日2010-12-29
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
2XQ0
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Structure of yeast LTA4 hydrolase in complex with Bestatin
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CHLORIDE ION, LEUKOTRIENE A-4 HYDROLASE, ...
著者Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M.
登録日2010-08-31
公開日2010-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.955 Å)
主引用文献A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
1HS6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ...
著者Thunnissen, M.M.G.M, Nordlund, P.N, Haeggstrom, J.Z.
登録日2000-12-24
公開日2001-06-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nat.Struct.Biol., 8, 2001
6SSR
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Crystal structure of Human Microsomal Glutathione S-Transferase 2 at 3.8 Angstroms resolution
分子名称: Microsomal glutathione S-transferase 2
著者Thulasingam, M, Nji, E, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2019-09-09
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
6SSS
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Crystal structure of Human Microsomal Glutathione S-Transferase 2
分子名称: 1-(8Z-hexadecenoyl)-sn-glycerol, GLYCEROL, Microsomal glutathione S-transferase 2, ...
著者Thulasingam, M, Nji, E, Haeggstrom, J.Z.
登録日2019-09-09
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.498 Å)
主引用文献Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
6SSW
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Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with an Inhibitor Glutathione sulfonic acid
分子名称: GLUTATHIONE SULFONIC ACID, Microsomal glutathione S-transferase 2
著者Thulasingam, M, Haeggstrom, J.Z.
登録日2019-09-09
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
6SSU
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Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with co-substrate Glutathione
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLUTATHIONE, Microsomal glutathione S-transferase 2, ...
著者Thulasingam, M, Haeggstrom, J.Z.
登録日2019-09-09
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
2UUI
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BU of 2uui by Molmil
Crystal structure of Human Leukotriene C4 Synthase
分子名称: DODECYL-BETA-D-MALTOSIDE, LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, ...
著者Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P.
登録日2007-03-02
公開日2007-07-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.
Nature, 448, 2007
2VJ8
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Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor
分子名称: 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ...
著者Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z.
登録日2007-12-07
公開日2008-01-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors
Faseb J., 16, 2002
2UUH
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Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione
分子名称: DODECYL-ALPHA-D-MALTOSIDE, GLUTATHIONE, LEUKOTRIENE C4 SYNTHASE, ...
著者Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P.
登録日2007-03-02
公開日2007-07-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.
Nature, 448, 2007
4NTF
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Mus Musculus LTC4 synthase in S-hexyl-GSH complex form
分子名称: Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ...
著者Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-12-02
公開日2015-01-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献To be published
To be Published
4NTA
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Mus Musculus LTC4 synthase in apo form
分子名称: Leukotriene C4 synthase, PALMITIC ACID, SULFATE ION
著者Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-12-02
公開日2015-01-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mus Musculus LTC4 synthase in apo form
To be Published
4NTB
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Mus Musculus LTC4 synthase in GSH complex form
分子名称: GLUTATHIONE, Leukotriene C4 synthase, NICKEL (II) ION, ...
著者Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-12-02
公開日2015-01-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mus Musculus LTC4 synthase in GSH complex form
To be Published
4MS6
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Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue
分子名称: 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, ACETIC ACID, Leukotriene A-4 hydrolase, ...
著者Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-09-18
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014

 

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件を2024-11-06に公開中

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