1AI0
| R6 HUMAN INSULIN HEXAMER (NON-SYMMETRIC), NMR, 10 STRUCTURES | Descriptor: | PHENOL, R6 INSULIN HEXAMER, ZINC ION | Authors: | Chang, X, Jorgensen, A.M.M, Bardrum, P, Led, J.J. | Deposit date: | 1997-04-30 | Release date: | 1997-11-12 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structures of the R6 human insulin hexamer. Biochemistry, 36, 1997
|
|
7F8Y
| Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide | Descriptor: | N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|
7F8U
| Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript | Descriptor: | 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|
6JK8
| Cryo-EM structure of the full-length human IGF-1R in complex with insulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | Authors: | Zhang, X, Yu, D, Wang, T. | Deposit date: | 2019-02-27 | Release date: | 2020-03-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. Structure, 28, 2020
|
|
5ZH0
| Crystal Structures of Endo-beta-1,4-xylanase II | Descriptor: | Endo-1,4-beta-xylanase 2, GLYCEROL, IODIDE ION | Authors: | Zhang, X, Wan, Q, Li, Z. | Deposit date: | 2018-03-10 | Release date: | 2019-03-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Crystal Structures of Endo-beta-1,4-xylanase II To be published
|
|
5Z93
| |
5Z94
| |
5ZE3
| |
1AIY
| R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 10 STRUCTURES | Descriptor: | PHENOL, R6 INSULIN HEXAMER, ZINC ION | Authors: | Chang, X, Jorgensen, A.M.M, Bardrum, P, Led, J.J. | Deposit date: | 1997-04-30 | Release date: | 1997-11-12 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structures of the R6 human insulin hexamer. Biochemistry, 36, 1997
|
|
6J6A
| |
7F8X
| Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056 | Descriptor: | ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056), Cholecystokinin receptor type A,Endolysin | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|
5ZH9
| |
3F4M
| Crystal structure of TIPE2 | Descriptor: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | Authors: | Zhang, X, Wang, J, Shi, Y. | Deposit date: | 2008-11-01 | Release date: | 2009-03-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Crystal structure of TIPE2 provides insights into immune homeostasis Nat.Struct.Mol.Biol., 16, 2009
|
|
3IYL
| Atomic CryoEM Structure of a Nonenveloped Virus Suggests How Membrane Penetration Protein is Primed for Cell Entry | Descriptor: | Core protein VP6, MYRISTIC ACID, Outer capsid VP4, ... | Authors: | Zhang, X, Jin, L, Fang, Q, Hui, W, Zhou, Z.H. | Deposit date: | 2010-02-02 | Release date: | 2010-05-12 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | 3.3 A cryo-EM structure of a nonenveloped virus reveals a priming mechanism for cell entry. Cell(Cambridge,Mass.), 141, 2010
|
|
3RYT
| The Plexin A1 intracellular region in complex with Rac1 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-A1, ... | Authors: | Zhang, X, He, H. | Deposit date: | 2011-05-11 | Release date: | 2012-01-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.582 Å) | Cite: | Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization. Sci.Signal., 5, 2012
|
|
1UON
| REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*GP*GP*GP*GP*GP*)-3', 5'-R(*UP*AP*GP*CP*CP*CP*CP*CP*)-3', ... | Authors: | Zhang, X, Walker, S.B, Chipman, P.R, Nibert, M.L, Baker, T.S. | Deposit date: | 2003-09-21 | Release date: | 2003-11-13 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Reovirus Polymerase Lambda3 Localized by Cryo-Electron Microscopy of Virions at a Resolution of 7.6 A Nat.Struct.Biol., 10, 2003
|
|
1ORH
| Structure of the Predominant Protein Arginine Methyltransferase PRMT1 | Descriptor: | GLYCEROL, Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Zhang, X, Cheng, X. | Deposit date: | 2003-03-13 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides Structure, 11, 2003
|
|
8T3Q
| Cryo-EM structure of the DHA bound FFA4-Gq complex | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | Deposit date: | 2023-06-07 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
|
|
8T3O
| Cryo-EM structure of the TUG-891 bound FFA4-Gq complex | Descriptor: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, ... | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | Deposit date: | 2023-06-07 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
|
|
8T3S
| Cryo-EM structure of the Butyrate bound FFA2-Gq complex | Descriptor: | CHOLESTEROL, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | Deposit date: | 2023-06-07 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
|
|
7CBQ
| Crystal structure of PDE4D catalytic domain in complex with Apremilast | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide, ... | Authors: | Zhang, X.L, Xu, Y.C. | Deposit date: | 2020-06-13 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. Eur.J.Med.Chem., 211, 2021
|
|
7CBJ
| Crystal structure of PDE4D catalytic domain in complex with compound 36 | Descriptor: | (1S)-1-[(7-chloranyl-1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | Authors: | Zhang, X.L, Xu, Y.C. | Deposit date: | 2020-06-12 | Release date: | 2021-06-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. Eur.J.Med.Chem., 211, 2021
|
|
7DY8
| Thermotoga maritima ferritin mutant-FLAL | Descriptor: | CALCIUM ION, FE (III) ION, Ferritin | Authors: | Zhang, X, Zhao, G. | Deposit date: | 2021-01-20 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials. Nat Commun, 12, 2021
|
|
7DV8
| The crystal structure of rice immune receptor RGA5-HMA2. | Descriptor: | Disease resistance protein RGA5 | Authors: | Zhang, X, Liu, J.F. | Deposit date: | 2021-01-12 | Release date: | 2021-10-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.447 Å) | Cite: | A designer rice NLR immune receptor confers resistance to the rice blast fungus carrying noncorresponding avirulence effectors. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7CTH
| Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Core protein, Single Chain Variable Fragment | Authors: | Zhang, X, Sharma, A, Duquerroy, S, Zhou, Z.H, Rey, F.A. | Deposit date: | 2020-08-19 | Release date: | 2021-12-01 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
|
|